World experience in the use of assisted reproductive technologies in recipients of solid organs

DOI

https://dx.doi.org/10.18565/aig.2025.196

Tyutyunnik V.L., Desyatkova N.V., Kan N.E., Soldatova E.E.
1) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) European Medical Center, Moscow, Russia

The article analyzes current literature data on the possibility of using assisted reproductive technologies (ART) in solid organ recipients. The following aspects are considered in the paper: the key factors of infertility pathogenesis, the effect of immunosuppressive therapy on fertility, the timing of restoration of reproductive function and the possibility of using ART. Organ dysfunction and immunosuppressive therapy have been shown to significantly reduce fertility, but the use of modern reproductive technologies makes it possible to achieve a successful pregnancy. The key factors are the timing of conception planning (not earlier than 1–2 years after transplantation), safe correction of immunosuppressive therapy and individual selection of stimulation protocols.
Conclusion. The problem of achieving conception after solid organ transplantation requires an interdisciplinary approach involving transplant surgeons, obstetricians, gynecologists, and reproductive medicine specialists. Despite the success of ART, the safety of immunosuppressive therapy during pregnancy remains a challenge. Optimization of ovarian stimulation protocols taking into account the type of transplant and any concomitant therapies as well as the development of unified recommendations for managing pregnancy in recipients are also important issues that need to be addressed. Further research in this area will improve pregnancy outcomes and expand childbearing opportunities for women after transplantation.

Authors’ contributions: Tyutyunnik V.L., Desyatkova N.V., Kan N.E., Soldatova E.E. – developing the concept and design of the study; obtaining the data for analysis, reviewing publications, processing and analyzing material on the subject, writing the manuscript, editing the article.
Conflicts of interest: The authors declare no conflicts of interest.
Funding: The study was conducted without sponsorship.
For citation: Tyutyunnik V.L., Desyatkova N.V., Kan N.E., Soldatova E.E. World experience in
the use of assisted reproductive technologies in recipients of solid organs.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (1): 12-18 (in Russian)
https://dx.doi.org/10.18565/aig.2025.196

reproductive health

organ transplantation

assisted reproductive technologies

preterm birth

fetal growth restriction

Full text (in Russian)

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Received 18.07.2025

Accepted 01.11.2025

Victor L. Tyutyunnik, Professor, Dr. Med. Sci., Leading Researcher of Research and Development Service, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4, tioutiounnik@mail.ru, Researcher ID: B-2364-2015,
SPIN-code: 1963-1359, Authors ID: 213217, Scopus Author ID: 56190621500, https://orcid.org/0000-0002-5830-5099
Nina V. Desyatkova, obstetrician-gynecologist-reproductologist, European Medical Center, 125040, Russia, Moscow, Pravda str., 15, build. 1, +7(903)222-42-42,
nineks@mail.ru, https://orcid.org/0009-0002-1430-2467
Natalia E. Kan, Professor, Dr. Med. Sci., Deputy Director for Research – Director of the Institute of Obstetrics, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4, kan-med@mail.ru, Researcher ID: B-2370-2015,
SPIN-code: 5378-8437, Authors ID: 624900, Scopus Author ID: 57008835600, https://orcid.org/0000-0001-5087-5946
Ekaterina E. Soldatova, PhD, Researcher at the Institute of Obstetrics, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4, katerina.soldatova95@bk.ru, https://orcid.org/0000-0001-6463-3403
Corresponding author: Nina V. Desyatkova, nineks@mail.ru

World experience in the use of assisted reproductive technologies in recipients of solid organs

Tyutyunnik V.L., Desyatkova N.V., Kan N.E., Soldatova E.E.

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