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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2026№7

Genetic determinants of sex hormone-binding globulin and myoma nodule volume in patients with uterine myoma

DOI
https://dx.doi.org/10.18565/aig.2026.53

Ponomarenko M.S., Reshetnikov E.A., Churnosova M.M., Churnosov M.I., Ponomarenko I.V.

Belgorod State National Research University, Belgorod, Russia

Objective. To investigate the association between polymorphisms in genes linked to sex hormone-binding globulin (SHBG) levels and myoma nodule volume in patients with uterine myomas.
Materials and methods. The study group comprised 329 patients with uterine myomas. Molecular genetic analysis was performed for eight gene loci associated with SHBG levels according to genome-wide association studies (GWAS): (rs17496332 [A/G] (1хр.) PRMT6, rs780093 [C/T] (2хр.) GCKR, rs3779195 [T/A] (7хр.) BAIAP2L1, rs440837 [A/G] (8хр.) ZBTB10, rs7910927 [G/T] (10хр.) JMJD1C, rs4149056 [T/C] (12хр.) SLCO1B1, rs8023580 [T/C] (15хр.) NR2F2, SHBG rs12150660 [G/T] (17хр.)). Associations between these candidate SHBG-related polymorphic loci and myoma nodule volume were assessed using the gPLINK software (linear regression).
Results. Associations with myoma nodule volume were identified for two of the eight molecular genetic markers analyzed. The minor G alleles of rs440837 [A/G] ZBTB10 (dominant model: β=-0.142, pperm=0.050) and rs17496332 [A/G] PRMT6 (allelic model: β=-0.131, pperm=0.018; additive model: β=-0.135, pperm=0.014; recessive model: β=-0.328, pperm=0.004) were associated with smaller myoma nodule volumes. The rs17496332 [A/G] PRMT6 polymorphism and 14 SNPs in linkage disequilibrium with it are associated with DNA interactions in the PRMT6 gene region involving 59 transcription factors and influence PRMT6 expression in more than 20 organs/tissues implicated in the pathophysiology of uterine myoma. The rs440837 [A/G] ZBTB10 polymorphic locus and five loci in strong linkage with it are located within the ZBTB10/RP11-48B3.3/RP11-48B3.4 gene region and influence DNA interactions with 22 transcription factors.
Conclusion. The G allelic variants of rs17496332 [A/G] PRMT6 and rs440837 [A/G] ZBTB10 are associated with the development of smaller myoma nodules in patients with uterine myoma.

Authors' contributions. Ponomarenko M.S. – conception and design of the study, data synthesis, drafting of the manuscript; Reshetnikov E.A. – drafting of the manuscript; Churnosova M.M. – literature search and analysis; Churnosov M.I. – review, final editing; Ponomarenko I.V. – statistical analysis, editing of the manuscript.
Conflicts of interest. The authors have no conflicts of interest to declare.
Funding. The study was conducted with the support of Russian Science Foundation grant No. 25-25-00034, 
https://rscf.ru/project/25-25-00034/.
Ethical Approval. The study was reviewed and approved by the Research Ethics Committee of the Belgorod State National Research University.
Generative Artificial Intelligence. No artificial intelligence tools were used in the preparation of this manuscript.
Patient Consent for Publication. All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement. The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.
For citation: Ponomarenko M.S., Reshetnikov E.A., Churnosova M.M., Churnosov M.I., Ponomarenko I.V. Genetic determinants of sex hormone-binding globulin and myoma nodule volume in patients with uterine myoma.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (7): 94-101 (in Russian)
https://dx.doi.org/10.18565/aig.2026.53

Keywords

sex hormone-binding globulin
polymorphism
myoma nodule volume
Full text (in Russian)

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Received 10.02.2026

Accepted 26.06.2026

About the Authors

Marina S. Ponomarenko, PhD student at the Department of Biomedical Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, ponomarenkomc@yandex.ru, https://orcid.org/0009-0009-0312-0829
Evgeny A. Reshetnikov, Dr. Bio. Sci., Professor at the Department of Medical and Biological Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, reshetnikov@bsuedu.ru, http://orcid.org/0000-0002-5429-6666
Maria M. Churnosova, student at the Medical Institute, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, churnosovamary@gmail.com, https://orcid.org/0000-0001-6444-8806
Mikhail I. Churnosov, Dr. Med. Sci., Head of the Department of Medical and Biological Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, churnosov@bsuedu.ru, https://orcid.org/0000-0003-1254-6134
Irina V. Ponomarenko, Dr. Med. Sci., Professor at the Department of Medical and Biological Disciplines, Belgorod State National Research University,
308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, ponomarenko_i@bsuedu.ru, https://orcid.org/0000-0002-5652-0166
Corresponding author: Irina V. Ponomarenko, ponomarenko_i@bsuedu.ru

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