The significance of lipidomic changes in ovarian neoplasms

DOI

https://dx.doi.org/10.18565/aig.2021.8.39-48

Iurova M.V., Pavlovich S.V., Khabas G.N., Chagovets V.V., Frankevich V.E., Ashrafyan L.A.
1) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

A number of lipids have tumor-initiating activity and this is the reason why the term "oncolipid" has been introduced. The content of various oncolipids in the tumor microenvironment reflects their ability to initiate and maintain the stages of carcinogenesis. This review analyzes the data available in the 2016–2020 literature from the databases Scopus, Medline, Cochrane, PubMed, eLibrary (with access to a full-text resource), and Web of Science, which is devoted to the study of lipid metabolic processes in ovarian malignancies. It analyzes the current promising studies of oncolipidomics, presents the possibilities of detecting early stage disease, summarizes data on the involvement of lipids in the process of initiation and progression of serous ovarian cancer and on the diagnostic and prognostic value of detecting lipidomic changes by mass spectrometry, and traces the relationship of these changes to the aggressiveness of the disease and its sensitivity to chemotherapy. The changes in the lipid composition are the pathogenetic result of accelerated cell division, impaired activation of the inositol-3-phosphate pathway, and intensive fatty acid β-oxidation. The largest number of studies is devoted to the classes of lipids, such as phosphatidylcholines and sphingomyelins. The activity of lysophosphatidic acid is one of the key factors in the process of tumor progression in ovarian cancer.
Conclusion. Interpretation of the study results is possible due to the unified lipid classification available in the Lipid Maps and Human Metabolome Database.

lipidome

markers

mass spectrometry

molecular biology

oncolipids

prediction

ovarian cancer

Full text (in Russian)

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Received 28.01.2021

Accepted 17.06.2021

Mariia V. Iurova, MD, specialist, Department of System Biology in Reproduction, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; post-graduate student, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Department of Obstetrics, Gynecology, Perinatology and Reproductive Health; the Faculty of Higher Professional Training. Tel.: +7(495)438-20-88. E-mail: m_yurova@oparina4.ru. ORCID: 0000-0002-0179-7635. 117997, Russia, Moscow, Ac. Oparina str., 4.
Stanislav V. Pavlovich, obstetrician-gynecologist, MD, PhD, Scientific secretary, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University). Tel.: +7(495)438-20-88. E-mail: s_pavlovich@oparina4.ru. ORCID: 0000-0002-1313-7079. 117997, Russia, Moscow, Ac. Oparina str., 4.
Grigory N. Khabas, surgeon, oncologist, obstetrician-gynecologist, MD, PhD, Head of the Department of Innovative Oncology and Gynecology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(495)438-78-33. E-mail: g_khabas@oparina4.ru.
117997, Russia, Moscow, Ac. Oparina str., 4.
Vitaliy V. Chagovets, PhD, Senior Researcher of the Laboratory of Proteomics and Metabolomics in Human Reproduction, Department of Systems Biology,
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(926)562-65-90.
E-mail: vvchagovets@gmail.com. ORCID: 0000-0002-5120-376X. 117997, Russia, Moscow, Ac. Oparina str., 4.
Vladimir E. Frankevich, PhD, Head of the Department of System Biology in Reproduction, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(495)438-07-88 (ex. 2198). E-mail: v_frankevich@oparina4.ru. ORCID: 0000-0002-9780-4579.
117997, Russia, Moscow, Ac. Oparina str., 4.
Lev A. Ashrafyan, Academician of the Russian Academy of Sciences, MD, Professor, Head of the Institute of Oncogynecology and Mammology, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(499)120-60-77. E-mail: levaa2004@yahoo.com.
ORCID: 0000-0001-6396-4948. 117997, Russia, Moscow, Ac. Oparina str., 4.

For citation: Iurova M.V., Pavlovich S.V., Khabas G.N., Chagovets V.V., Frankevich V.E., Ashrafyan L.A. The significance of lipidomic changes in ovarian neoplasms.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 8: 39-48 (in Russian)
https://dx.doi.org/10.18565/aig.2021.8.39-48

The significance of lipidomic changes in ovarian neoplasms

Iurova M.V., Pavlovich S.V., Khabas G.N., Chagovets V.V., Frankevich V.E., Ashrafyan L.A.

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