Cell-free components of malignant ascites and their potential role in effective therapy for serous ovarian cancer

DOI

https://dx.doi.org/10.18565/aig.2024.309

Slonov A.V., Shender V.O., Aleshikova O.I., Gerfanova E.V., Babaeva N.A., Ashrafyan L.A., Sukhikh G.T.
1) Clinical Hospital No. 123, Lopukhin Federal Research and Clinical Centre for Physical and Chemical Medicine of Federal Biological Agency, Odintsovo, Russia; 2) Lopukhin Federal Research and Clinical Centre for Physical and Chemical Medicine of Federal Biological Agency, Moscow, Russia; 3) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

Ovarian cancer is a malignant neoplasm characterized by the highest mortality rate of all gynecological cancers due to the fact that it is usually diagnosed at a late stage. High-grade serous ovarian cancer is more often associated with ascites formation. Malignant ascites appears to provide a microenvironment that promotes ovarian cancer progression.
The data of the Russian and foreign studies give insight into the numerous components of ascites. Malignant ascites contains not only different cell populations but also cell-free components involved in forming a microenvironment for tumor cells and promoting their progression (integrins, cytokines and growth factors such as VEGF, IL-6 and IL-8 that cause angiogenesis, invasion and chemoresistance). Cell-free factors, which are known to be activated in ascites in ovarian cancer, can induce epithelial-mesenchymal transition, and this may indicate a more aggressive course of the disease.
Conclusion: The mapping of proteins and different metabolites of malignant ascites in ovarian cancer is expected to facilitate a more profound understanding of the signal transduction networks which vary with disease progression. The study of malignant ascites and the associated microenvironment that promotes the initiation of tumor cell growth and proliferation in ovarian cancer may change the tactics of therapy and improve its efficacy.

Authors’ contributions: Slonov A.V., Shender V.O. – developing the design of the study; Aleshikova O.I., Gerfanova E.V., Babaeva N.A. – writing and editing the text; Ashrafyan L.A. – organization of the study and developing the concept of the study.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
Acknowledgements: The authors express their gratitude to M.A. Lagarkova, Dr. Bio. Sci., Prof., Corresponding Member of RAS, CEO, Lopukhin Federal Research and Clinical Centre for Physical-Chemical Medicine, for her assistance in the preparation of the article.
For citation: Slonov A.V., Shender V.O., Aleshikova O.I., Gerfanova E.V., Babaeva N.A., Ashrafyan L.A., Sukhikh G.T. Cell-free components of malignant ascites and their potential role in effective therapy for serous ovarian cancer.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (3): 13-20 (in Russian)
https://dx.doi.org/10.18565/aig.2024.309

ovarian cancer

ascites

tumor cells

tumor microenvironment

Full text (in Russian)

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Received 05.12.2024

Accepted 10.02.2025

Andrey V. Slonov, PhD, Chief Physician, Clinical Hospital No.123 of Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of FMBA of Russia,
143007, Russia, Moscow Region, Odintsovo, Krasnogorskoye Shosse, 15, dr.slon83@gmail.com, https://orcid.org/0000-0003-4416-7315
Victoria O. Shender, PhD (in Chemistry), Head of the Laboratory of Molecular Oncology, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine
of FMBA of Russia, 119435, Russia, Moscow, Malaya Pirogovskaya str., 1a, shender_vika@mail.ru, https://orcid.org/0000-0001-9156-2938
Olga I. Aleshikova, PhD, Senior Researcher at the Institute of Oncogynecology and Mammology, oncologist at the Oncological Department of Surgical Methods of Treatment, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow,
Ac. Oparin str., 4, olga.aleshikova@gmail.com, https://orcid.org/0000-0002-2957-3940
Evgeniya V. Gerfanova, PhD, oncologist-gynecologist at the Institute of Oncogynecology and Mammology, Department of Innovative Oncology and Gynecology, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, +7(916)752-71-87, evgeniyagerf@gmail.com, e_gerfanova@oparina4.ru, https://orcid.org/0000-0001-9092-7149
Nataliya A. Babaeva, Dr. Med. Sci., Leading Researcher at the Institute of Oncogynecology and Mammology, oncologist at the Oncological Department of Surgical Methods
of Treatment, V.I. Kulakov National Medical Research Center of the Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4, n_babaeva@oparina4.ru,
https://orcid.org/0000-0002-4654-9512
Lev A. Ashrafyan, Academician of the Russian Academy of Sciences, Professor, Dr. Med. Sci., Head of the Institute of Oncogynecology and Mammology,
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow,
Ac. Oparin str., 4, levaa2004@yahoo.com, https://orcid.org/0000-0001-6396-4948
Gennady T. Sukhikh, Dr. Med. Sci., Professor, Academician of the RAS, Director of the Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4, sekretariat@oparina4.ru, https://orcid.org/0000-0002-7712-1260
Corresponding author: Evgeniya V. Gerfanova, evgeniyagerf@gmail.com

Cell-free components of malignant ascites and their potential role in effective therapy for serous ovarian cancer

Slonov A.V., Shender V.O., Aleshikova O.I., Gerfanova E.V., Babaeva N.A., Ashrafyan L.A., Sukhikh G.T.

Keywords

References

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