Implication of vitamin D deficiency in the development of severe forms of preeclampsia in women at high risk
Objective. To investigate vitamin D provision in women at high risk for preeclampsia and to reduce the occurrence of its severe form by correcting vitamin D deficiency during pregnancy and pregravid preparation.Maltseva L.I., Vasilyeva E.N., Denisova T.G.
Subjects and methods. The investigation enrolled 172 patients at high risk for preeclampsia; among them, there were 102 patients who took vitamin D and calcium and 70 patients who did not. Over the course of gestation, the serum concentrations of vitamin D, vitamin D-binding protein, ionized calcium, renin, and endothelin 1-38 were measured in the women, and the umbilical cord blood levels of 25(OH)D were estimated in their newborns.
Results. The women at risk for preeclampsia have vitamin D deficiency. The use of Aquadetrim 4000 IU and Ca 500 mg as from the stage of pregravid preparation prevents preeclampsia and severe perinatal injuries.
Conclusion. Increasing the dose of vitamin D up to 4000 IU from the stage of pregravid preparation and during pregnancy is optimal for women at high risk for preeclampsia.
Keywords
pregnancy
preeclampsia
vitamin D deficiency
pregravid preparation
perinatal complications
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Received 08.06.2018
Accepted 22.06.2018
About the Authors
Maltseva, Larisa I., MD, professor, head of the Obstetrics and Gynecology Department № 1, Kazan State Medical Academy, Branch, Russian Medical Academyof Continuing Postgraduate Education, Ministry of Health of Russia. 422012, Russia, Kazan, Mushtari str. 11. Tel.: +79053144051. E-mail: laramalc@mail.ru
Vasilyeva, Elvira N., PhD in Medical Sciences, associate professor of the department of Obstetrics and Gynecology, I.N. Ulyanov Chuvash State University.
428000, Russia, Cheboksary, Moscow Avenue, 15. Tel.: +78352488665. E-mail: elnikvas@mail.ru
Denisova, Tamara G., MD, professor, Vice-Rector for Research and Informatization, Institute for Postgraduate Training of Physicians, Ministry of Health of Chuvashia; professor of the department of Obstetrics and Gynecology, I.N. Ulyanov Chuvash State University.
428000, Russia, Cheboksary, Moscow Avenue, 15. Tel.: +79051973707. E-mail: tomadenisova@rambler.ru
For citations: Maltseva L.I., Vasilyeva E.N., Denisova T.G. Implication of vitamin D deficiency in the development of severe forms of preeclampsia in women at high risk. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (9): 120-5. (in Russian)
https://dx.doi.org/10.18565/aig.2018.9.120-125
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