A rare clinical case of delivery of a patient after surgical treatment of ovarian yolk sac tumor
Renge L.V., Grigorieva E.Yu., Samusenko N.A., Levchenko V.G., Likhacheva V.V., Shramko S.V., Likhachev B.A.
Background: Yolk sac tumors account for 10–20% of all malignant germ cell tumors of the ovary. They are more common in children, adolescents and young women, and are classified as aggressive, fast-growing tumors. They have the least favorable prognosis of all germ cell tumors. The combination of surgical treatment with adjuvant chemotherapy involving platinum preparations has been shown to achieve positive results, with 5-year overall survival rates ranging from 80 to 95%, depending on the stage of the tumor process. The modern approach to treatment makes it possible to predict a favorable outcome in yolk sac tumor in terms of preserving not only life but also the girl’s reproductive function.
Case report: This is a clinical case study of a caesarean section performed on a 20-year-old female patient who underwent surgery at the age of 15 for an ovarian yolk sac tumor, ascites and implantation metastasis of the anterior abdominal wall. The patient received five courses of chemotherapeutic treatment based on cisplatin, etoposide and ifosfamide (PEI). The subsequent course started on day 22 from the beginning of the previous course, provided that the neutrophil count was above 500/μL and the platelet count was above 80,000/μL.
After the 4 courses of chemotherapy, she underwent Pfannenstiel laparotomy, removal of the affected ovary, implantation metastasis, and exploration of the abdominal cavity. The postoperative period proceeded without complications, and the 5th course of chemotherapy was subsequently performed. Rehabilitation was successful due to the teamwork of obstetricians, oncologists, chemotherapists and psychologists. Psychological support was provided during the entire chemotherapy period.
Conclusion: The modern level of medical science with timely diagnosis and adequate treatment of yolk sac tumor provides a favorable prognosis in preserving life and reproductive function of a girl. Clinical observation could benefit obstetricians, as well as pediatric gynecologists, oncologists and pediatric surgeons.
Authors’ contributions: Renge L.V., Levchenko V.G. – developing the concept and design of the study; Samusenko N.A., Levchenko V.G., Likhacheva V.V. – collecting and processing the material; Renge L.V., Levchenko V.G., Grigorieva E.Yu., Likhacheva V.V., Shramko S.V. – writing the text; Samusenko N.A., Levchenko V.G., Likhacheva V.V. – editing the article; Likhachev B.A. – literature review, translation into English.
Conflicts of interest: Authors declare lack of the possible conflicts of interest.
Funding: The study was carried out without sponsorship.
Patient Consent for Publication: The patient provided an informed consent for the publication of her data and associated images.
For citation: Renge L.V., Grigorieva E.Yu., Samusenko N.A., Levchenko V.G., Likhacheva V.V., Shramko S.V., Likhachev B.A. A rare clinical case of delivery of a patient after surgical treatment of ovarian yolk sac tumor.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (6): 178-183 (in Russian)
https://dx.doi.org/10.18565/aig.2024.336
Keywords
yolk sac tumor
treatment
pregnancy
delivery
clinical case
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Received 27.12.2024
Accepted 21.05.2025
About the Authors
Lyudmila V. Renge, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Novokuznetsk State Institute for Further Training of Physicians –Branch of the Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia, 5, Stroiteley Ave., Novokuznetsk, 654005, Russia,
+7(906)-933-77-07, l.renge@mail.ru, https://orcid.org/0000-0002- 7237-9721
Ekaterina Yu. Grigorieva, PhD, Associate Professor, Department of Obstetrics and Gynecology, Novokuznetsk State Institute for Further Training of Physicians – Branch of the Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia, 5, Stroiteley Ave., Novokuznetsk, 654005, Russia, +7(3843)454-873, prutovykh@icloud.com, https://orcid.org/0000-0002-8623-729Х
Natalia A. Samusenko, obstetrician-gynecologist, G.P. Kurbatov Novokuznetsk City Clinical Hospital No. 1, 5, Stroiteley Ave., Novokuznetsk, 654005, Russia,
+7(3843)454-873.
Vladimir G. Levchenko, PhD, Associate Professor, Department of Obstetrics and Gynecology, Novokuznetsk State Institute for Further Training of Physicians – Branch
of the Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia, 5, Stroiteley Ave., Novokuznetsk, 654005, Russia, +7(903)908-18-71,
vglev@ya.ru, https://orcid.org/0000-0002-2809-0568
Victoria V. Likhacheva, Dr. Med. Sci., Associate Professor, Professor, Department of Obstetrics and Gynecology, Novokuznetsk State Institute for Further Training of Physicians – Branch of the Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia, 5, Stroiteley Ave., Novokuznetsk, 654005, Russia,
+7(905)905-35-49, viroli@mail.ru, https://orcid.org/0000-0002-5637-7590
Svetlana V. Shramko, Dr. Med. Sci., Associate Professor, Professor, Department of Obstetrics and Gynecology, Novokuznetsk State Institute for Further Training of Physicians – Branch of the Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia, 5, Stroiteley Ave., Novokuznetsk, 654005, Russia, +7(961)714-00-13, shramko_08@mail.ru, https://orcid.org/0000-0003-1299-165X
Boris A. Likhachev, PhD Student at the Department of Genetics and Fundamental Medicine, Kemerovo State University, 73 bld. 2, Sovetsky Ave., Kemerovo, 650043, Russia, +7(906)930-86-01, viroli@mail.ru
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