Possibilities of vaccination in the elimination of cervical cancer: achievements and prospect

Minkina G.N.

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia
More than 10 years of global experience with prophylactic human papillomavirus (HPV) vaccines suggest that the latter are safe and highly effective. There is convincing evidence that in countries where HPV vaccination programs are implemented, the incidence of genital warts and the incidence of cervical precancerous lesions have substantially decreased in the respective populations and in 2018 there was the first evidence for the effectiveness of vaccination against invasive HPV-associated cancers. It is predicted that cervical cancer will become an extremely rare disease over the next few decades and can be completely eradicated by the end of the century in developed countries where a high vaccination and screening coverage remains.


human papillomavirus
genital warts
cervical cancer


  1. WHO. Human papillomavirus (HPV) and cervical cancer. 24.01.2019. Available at: https://www.who.int/ru/news-room/fact-sheets/detail/human-papillomavirus-(hpv)-and-cervical-cancer
  2. WHO. WHO Director-general calls for all countries to take action to help end the suffering caused by cervical cancer. May 19, 2018. Available at: https://www.who.int/reproductivehealth/DG_Call-to-Action.pdf
  3. Каприн А.Д., Старинский В.В., Петрова Г.В., ред. Злокачественные новообразования в России в 2017 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИРЦ» Минздрава России; 2018. 250 с. [Kaprin A.D., Starinsky V.V., Petrova G.V., ed. Malignant neoplasms in Russia in 2017 (morbidity and mortality). Moscow: MNIOI im. P.A. Herzen – branch of the NWIRTC of the Ministry of Health of Russia; 2018. 250 p. (in Russ.)]
  4. Barchuk A., Bespalov A., Huhtala H., Chimed T., Laricheva I., Belyaev A. et al. Breast and cervical cancer incidence and mortality trends in Russia 1980-2013. Cancer Epidemiol. 2018; 55: 73-80.
  5. WHO. Vaccine in National Immunization Programme Update June 2019. Available at: https://www.who.int/immunization/monitoring_surveillance/en/
  6. Maver P.J., Poljak M. Progress in prophylactic human papillomavirus (HPV) vaccination in 2016: A literature review. Vaccine. 2018; 36(36): 5416-23.
  7. Department of Health and Ageing. Immunise Australia program: human papillomavirus (HPV). February 14, 2013. Available at: http://www.health.gov.au/internet/immunise/publishing.nsf/ Content/immunise-hpv
  8. Office of the Prime Minister of Australia. A new vaccine to strengthen the health of young Australians. October 8, 2017. Available at: http://parlinfo.aph.gov au/parlInfo/search/display/display.w3p;query=Id%3A%22media%2F pressrel%2F5562151%22
  9. Cancer Council Australia Cervical Cancer Screening Guidelines Working Party. National cervical screening program: guidelines for the management of screen-detected abnormalities, screening in specific populations and investigation of abnormal vaginal bleeding. December 4, 2017. Available at: http://wiki.cancer.org.au/australia/Guidelines:Cervical_cancer/Screening
  10. Kirby Institute. HIV, viral hepatitis and sexually transmissible infections in Australia: annual surveillance report 2018. Sydney: Kirby Institute, UNSW Sydney; 2018. Available at: https://kirby.unsw.edu.au/report/hiv-viral-hepatitis-and-sexually-transmissible-infections-australia-annual-surveillance
  11. Victorian Cervical Cytology Registry. Statistical Report 2015. Available at: https://www.vccr.org/data-research/statistical-reports/annual-statistical-reports
  12. Steben M., Tan Thompson M., Rodier C., Mallette N., Racovitan V., DeAngelis F. et al. A review of the impact and effectiveness of the quadrivalent human papillomavirus vaccine: 10 years of clinical experience in Canada. J. Obstet. Gynaecol. Can. 2018; 40(12): 1635-45.
  13. Garland S.M., Kjaer S.K., Muñoz N., Block S.L., Brown D.R., DiNubile M.J. et al. Impact and effectiveness of the quadrivalent human papillomavirus vaccine: a systematic review of 10 years of real-world experience. Clin. Infect. Dis. 2016; 63(4): 519-27.
  14. Drolet M., Bénard É., Pérez N., Brisson M.; HPV Vaccination Impact Study Group. Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis. Lancet. 2019; Jun 26. pii: S0140-6736(19)30298-3.
  15. Luostarinen T., Apter D., Dillner J., Eriksson T., Harjula K., Natunen K. et al. Vaccination protects against invasive HPV-associated cancers. Int. J. Cancer. 2018; 142(10): 2186-7.
  16. Markowitz L.E., Dunne E.F., Saraiya M., Chesson H.W., Curtis C.R., Gee J. et al. Human papillomavirus vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep. 2014; 63(RR-05): 1-30.
  17. Petrosky E., Bocchini J.A. Jr, Hariri S., Chesson H., Curtis C.R., Saraiya M. et al. Use of 9-valent human papillomavirus (HPV) vaccine: updated HPV vaccination recommendations of the advisory committee on immunization practices. MMWR Morb. Mortal. Wkly Rep. 2015; 64(11): 300-4.
  18. Guo F., Cofie L.E., Berenson A.B. Cervical cancer incidence in young U.S. females after human papillomavirus vaccine introduction. Am. J. Prev. Med. 2018; 55(2): 197-204.
  19. Hall M.T., Simms K.T., Lew J.B., Smith M.A., Brotherton J.M., Saville M. et al. The projected timeframe until cervical cancer elimination in Australia: a modelling study. Lancet Publ. Health. 2019; 4(1): e19-27.
  20. Simms K. Predicting declines in cervical cancer due to vaccination: the global perspective. In: Presented at EUROGIN 2018. Lisbon, Portugal. Abstr. 00570.
  21. Kjaer S.K., Nygård M., Dillner J., Brooke Marshall J., Radley D., Li M. et al. A 12-year follow-up on the long-term effectiveness of the quadrivalent human papillomavirus vaccine in 4 Nordic countries. Clin. Infect. Dis. 2018; 66(3): 339-45.
  22. Kruger-Kjaer S., Nygard M., Dillner J., Munk C., Hansen B., Sigurdardottir L. Et al. In: Presented at EUROGIN 2018. Lisbon, Portugal. Abstr. 00625.
  23. WHO. Safety update of HPV vaccines. Available at: http://www.who.int/vaccine_safety/committee/topics/hpv/June_2017/e
  24. Краснопольский В.И. и соавт. Эффективность вакцинопрофилактики ВПЧ-ассоциированных заболеваний и рака шейки матки в Московской области. Almanac of Clinical Medicine. 2015; 37: 105-110. [Krasnopol’skiy V.I. et al. Efficacy of vaccine prevention of HPV-associated diseases and cervical cancer in the Moscow region. Almanakh of the clinical medicine. 2015; 37: 105-110 (in Russ.)]
  25. Зароченцева Н.В., Белая Ю.М. Опыт реализации программ первичной профилактики заболеваний, вызываемых вирусом папилломы человека, в Московской области. Эпидемиология и Вакцинопрофилактика. 2017; 97(6): 59-65. [Zarochentseva N.V., Belaiya J.M. Experience in the Implementation of Programs for Primary Prevention of Human Papillomavirus-associated Diseases in the Moscow region. Epidemiology and Vaccinal Prevention. 2017: 97(6): 59-65 (in Russ.)]
  26. Белоцерковцева Л.Д. и соавт. Внедрение региональной программы вакцинации против ВПЧ-ассоциированных заболеваний в ХМАО-Югре. Педиатрическая фармакология. 2014; 11(4): 29-34 [Belotserkovtseva L.D. et al. Regional Vaccination Program, Vaccination of Adolescents, Quadrivalent Human Papillomavirus Recombinant Vaccine, Cervical Cancer. Pediatricheskaya farmakologiya/Pediatric pharmacology. 2014; 11 (4): 29-34 (in Russ.)]
  27. Белоцерковцева Л.Д. и соавт. Репродуктивное поведение подростков и опыт профилактики ВПЧ-ассоциированных заболеваний в ХМАО-Югре. Вопросы гинекологии, акушерства и перинатологии. 2018; 17(1): 100-8. [Belotserkovtseva L.D. et al. Reproductiveehavior of adolescents and an experience of preventing HPV-associated diseases in the Khanty-Mansi Autonomous Okrug-Yugra. Gynecology, Obstetrics and Perinatology. 2018; 17(1): 100-8.(in Russ.)]

Received 06.06.2019

Accepted 21.06.2019

About the Authors

Minkina Galina N., Professor of Moscow State Medical Stomatological University.
Tel.: +79037928215. E-mail: minkinagn@mail.ru
Delegatskaya st., 20/1, 127473, Moscow, Russia.

For citation: Minkina G.N. The potential of vaccination to eliminate cervical cancer: achievements and prospects.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; 8: 40-45 (in Russian).

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