Possibilities for systemic enzyme therapy in patients with chronic endometritis after missed abortion

Ordiyants I.M., Kogan E.A., Barabasheva S.S., Molchanova O.K.

1) Peoples Friendship University of Russia, Ministry of Education and Science of Russia, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia
Objective. To evaluate the effectiveness of systemic enzyme therapy in patients with chronic endometritis after missed abortion on the basis of morphological and immunohistochemical studies.
Materials and methods. The study included 37 reproductive-aged women with missed miscarriage. Wobenzym was used in rehabilitation therapy after artificial abortion in 30 women. The conditions of the endometrium was studied by morphological and immunohistochemical methods before and after rehabilitation therapy.
Results. The morphological signs of chronic inflammation were eliminated during the treatment with preparation Wobenzym; their elimination is confirmed by a decrease in the expression of HLA-DR and the disappearance of CD16+, CD20+, NK-lymphocytes and B-lymphocytes in the stroma. Indifferent endometrium in patients treated with Wobenzym was detected only in 6.7% of cases, secretory endometrium was detected in 73.3% of women, proliferative endometrium – in 26.7%.
Conclusion. The use of Wobenzym after instrumental abortion in patients with endometritis and undeveloped pregnancy eliminates morphological signs of inflammation and promotes endometrial regeneration.

Keywords

missed abortion
systemic enzyme therapy
Wobenzym
chronic endometritis

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Received 07.12.2020

Accepted 17.12.2020

About the Authors

Irina M. Ordiyants, Dr.Med.Sci., Professor, professor of the Department of Obstetrics and Gynecology with the course of Perinatology, Medical Institute Peoples’ Friendship University of Russia. Tel.: +7(926)800-50-36. E-mail: ordiyantc@mail.ru.
8 Miklukho-Maklaya str., Moscow, 117198, Russia.
Yevgenia A. Kogan, Dr.Med.Sci., Professor, Head of the Department of Pathological Anatomy named after academician A.I. Strukov, I.M. Sechenov Moscow State Medical University, Ministry of Health of Ruissia. E-mail: koganevg@gmail.com.
8-2 Trubetskaya str., Moscow, 119991, Russia.
Sofya S. Barabasheva, post-graduate student of the Department of Obstetrics and Gynecology with the course of Perinatology, Medical Institute Peoples’ Friendship University of Russia. Tel.: +7(926)822-71-58. E-mail: vurkina@list.ru.
8 Miklukho-Maklaya str., Moscow, 117198, Russia.
Olga K. Molchanova, resident of the Department of Obstetrics and Gynecology with the course of Perinatology, Medical Institute Peoples’ Friendship University of Russia. Tel.: +7(906)096-81-31. E-mail: olgamolchanova1994@yandex.ru.
8 Miklukho-Maklaya str., Moscow, 117198, Russia.

For citation: Ordiyants I.M., Kogan E.A., Barabasheva S.S., Molchanova O.K. Possibilities for systemic enzyme therapy in patients with chronic endometritis after missed abortion.
Akusherstvo i Ginekologiya / Obstetrics and gynecology. 2020; 12: 186-193 (in Russian)
https://dx.doi.org/10.18565/aig.2020.12.186-193

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