Ultrasound assessment of the effect of chronic endometritis treatment

Ozerskaya I.A., Kazaryan G.G., Gus A.I.

1) Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia; 2) Medscan LLC, Moscow, Russia; 3) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

Objective: To assess the dynamics of echographic changes in the endometrium in patients receiving complex treatment for chronic endometritis using cytokine therapy.
Materials and methods: This was a retrospective analysis of 298 reproductive-aged women diagnosed with chronic endometritis. The main group consisted of 140 patients who received standard anti-inflammatory treatment supplemented with cytokine therapy. The comparison group included 158 women who were treated with a similar complex but they did not receive cytokine therapy. There was an assessment of the ultrasound parameters which were used for ultrasound diagnosis of chronic endometritis.
Results: After therapy there was a statistically significant decrease (p<0.05) in the thickness and volume of the endometrium, as well as a decrease in the frequency of detection of most ultrasound signs of chronic endometritis. The disappearance of fluid and gas bubbles from the uterine cavity turned out to be the most pronounced effect of the treatment. The echogenicity of the endometrium and its heterogeneous structure did not change much (p>0.05).
Conclusion: The use of cytokine therapy in the complex treatment of chronic endometritis makes it possible to bring the ultrasound criteria closer to the standard parameters; the changes in the criteria indicate the partial restoration of the endometrium.

Authors’ contributions: Ozerskaya I.A. – developing the concept and design of the study, statistical data processing, supervising research, editing the text; Kazaryan G.G. – searching for literary sources, collecting and analyzing data, writing the article; Gus A.I. – developing the concept of the study, editing the article.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was approved by the Ethical Review Board of the Peoples’ Friendship University of Russia.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator I.A. Ozerskaya.
For citation: Ozerskaya I.A., Kazaryan G.G., Gus A.I. 
Ultrasound assessment of the effect of chronic endometritis treatment. 
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (4): 132-138 (in Russian)


ultrasound diagnosis
chronic endometritis
exogenous cytokine therapy


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Received 27.02.2024

Accepted 04.04.2024

About the Authors

Irina A. Ozerskaya, Dr. Med. Sci., Professor, Department of Ultrasound Diagnostics, RUDN University, 117198, Russia, Moscow, Miklukho-Maklaya str., 6, +7(499)936-87-87, ozerskaya_usd@mail.ru, https://orcid.org/0000-0001-8929-6001
Gayane G. Kazaryan, PhD, Ultrasound Diagnostics Doctor, Medscan, 119421, Russia, Moscow, Obrucheva str., 21A, +7(495)859-29-45, 79165521271@yandex.ru,
Alexander I. Gus, Dr. Med. Sci., Professor, Chief Researcher, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparina str., 4; Head of the Department of Ultrasound Diagnostics, RUDN University,
Corresponding author: Irina A. Ozerskaya, ozerskaya_usd@mail.ru

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