Experience with bovhyaluronidase azoximer used in the combination treatment of chronic endometritis in women with repeated implantation failures
Objective: To evaluate the efficiency of using bovhyaluronidase azoximer in the combination treatment of chronic endometritis in women with repeated implantation failures (RIFs). Materials and methods: Examinations were made in 84 women with chronic endometritis and RIFs who had been treated using in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in the “PERSONA” International Clinical Center of Reproductology (Almaty, Kazakhstan) in January 2020 to January 2022 and followed up within 9 months after treatment. Two groups were identified by the treatment method: a study group that received antibacterial therapy in combination with bivhyaluronidase azoximer; a control group used antibacterial therapy alone. Results: After treatment, a negative result to the expression of CD138+ cells was considerably frequent in the study group than in the control group (0.88±1.27 versus 6.48±7.40; p=0.00014). The pregnancy rate in the first cycle after transfer of a single frozen-thawed embryo was statistically higher in the study group than in the control group (78% versus 41.1%; р<0.001). Accordingly, the live birth rate was also higher in the study group than in the control group (62% versus 32.3%; р=0.008). Conclusion: Chronic endometritis frequently occurs in women with RIFs. The results of the conducted study showed the high efficiency of using bovhyaluronidase azoximer in combination with antibacterial therapy, a substantial reduction in the expression of CD138+ cells, and increases in the rate of pregnancy, and the live birth rates in this category of women. Authors' contributions: Abshekenova A.T., Rybina A.N., Askar E. – concept; Lokshin V.N., Rybina A.N., Askar E. – scientific design; Lokshin V.N., Abshekenova A.T., Rybina A.N., Askar E., Karibaeva Sh.K., Valiev R.K. – interpretation of the findings; Lokshin V.N., Abshekenova A.T., Rybina A.N., Askar E., Karibaeva Sh.K., Valiev R.K. – creation of the scientific article. Conflicts of interest: The authors declare that there are no conflicts of interest. Funding: This investigation has been conducted free of charge. Ethical Approval: The ethic approval has been obtained from the Local Ethics Committee, “PERSONA” International Clinical Center of Reproductology, in December 2019. Patient Consent for Publication: The patients have signed an informed consent form to the publication of their data. Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator. For citation: Lokshin V.N., Askar E., Rybina A.N., Abshekenova A.T., Karibaeva Sh.K., Valiev R.K. Experience with bovhyaluronidase azoximer used in the combination treatment of chronic endometritis in women with repeated implantation failures. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (5): 108-112 (in Russian) https://dx.doi.org/10.18565/aig.2023.119Lokshin V.N., Askar E., Rybina A.N., Abshekenova A.T., Karibaeva Sh.K., Valiev R.K.
Keywords
chronic endometritis
CD138+
bovhyaluronidase azoximer
outcomes of IVF/ICSI
RIF
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Received 10.05.2023
Accepted 16.05.2023
About the Authors
Vyacheslav N. Lokshin, Academician of the National Academy of Sciences of the Republic of Kazakhstan, Professor, Chief Reproductive Specialist of the Ministry of Reproductive Medicine, President of the Kazakhstan Association of Reproductive Medicine, General Director of the “PERSONA” International Clinical Center of Reproductology, +77017558209, v_lokshin@persona-ivf.kz, Utepova 32a, Almaty, Kazakhstan, https://orcid.org/0000-0002-4792-5380Yenglik Askar, Obstetrician-Gynecologist, “PERSONA” International Clinical Center of Reproductology; Doctoral Student, Asfendiyarov Kazakh National Medical University, +77075670670, yenglik.askar@yahoo.com, Utepova 32a, Almaty, Kazakhstan, https://orcid.org/0000-0002-2538-3728
Anastasia N. Rybina, Reproductive Specialist, Obstetrician-Gynecologist, “PERSONA” International Clinical Center of Reproductology, Doctoral Student, Asfendiyarov
Kazakh National Medical University, +77772636715, oedema@mail.ru, Utepova 32a, Almaty, Kazakhstan, https://orcid.org/0000-0002-9368-66837
Aigerim T. Abshekenova, Reproductive Specialist, Obstetrician-Gynecologist, “PERSONA” International Clinical Center of Reproductology; Doctoral Student, Asfendiyarov Kazakh National Medical University, +77078305002, abshekenova@gmail.com, Utepova 32a, Almaty, Kazakhstan, https://orcid.org/0000-0002-3138-6650
Sholpan K. Karibayeva, PhD, Associate Professor of the Department of Obstetrics and Gynecology, Asfendiyarov Kazakh National Medical University; Reproductologist, Obstetrician-Gynecologist, Director of Strategic Development, “PERSONA” International Clinical Center of Reproductology, +77017550675, sh.karibaeva@gmail.com, Utepova 32a, Almaty, Kazakhstan, https://orcid.org/0000-0001-5691-8652
Ravil K. Valiev, PhD, Reproductive Specialist, Obstetrician-Gynecologist,“PERSONA” International Clinical Center of Reproductology, +77772258189, rvaliev75@mail.ru, Utepova 32a, Almaty, Kazakhstan, https://orcid.org/0000-0003-2526-42917
Corresponding author: Yenglik Askar, yenglik.askar@yahoo.com
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