Evaluation of the effectiveness of complex treatment for chronic endometritis resulting in thin endometrium in patients with impaired reproductive function
Kravchenko E.N., Novitskaya E.L., Sabitova N.L., Lisitsa E.V.
Objective: To evaluate the effectiveness of complex treatment for chronic endometritis (CE) resulting in thin endometrium in patients with impaired reproductive function.
Materials and methods: The study included 150 women with impaired reproductive function due to CE that progressed to thin endometrium and caused infertility. The patients of the main group (n=50) received complex treatment including antibacterial therapy and local cytokine therapy (Superlymph) in combination with irrigation of the uterine cavity with cavitated solution. Comparison group I (n=50) consisted of women who received complex treatment including antibacterial therapy in combination with irrigation of the uterine cavity with cavitated solution. Comparison group II (n=50) included women who received only antibiotic therapy.
Results: The treatment of CE using the Superlymph medication at a dose of 25 IU during the course of 20 days together with irrigation of the uterine cavity with cavitated solution and antibiotic therapy has a high clinical efficacy. Endometrial thickness increased by 1.9 times compared to local intrauterine and antibiotic therapy, and by 3.5 times compared to antibiotic monotherapy. This treatment more often contributes to the formation of a three-layered endometrium on the days of ovulation and homogeneity of the uterine junctional zone with a clear echogenic line. The blood flow increases in uterine vessels at the level of basal and spiral arteries, the resistance index rises. Histological examination is less likely to show evidence of CE. Pregnancy occurs more often (58% versus 34% in comparison group I and versus 22% in comparison group II).
Conclusion: The treatment of CE using the Superlymph medication at a dose of 25 IU during the course of 20 days together with irrigation of the uterine cavity with cavitated solution and antibiotic therapy has a high clinical efficacy: echographic parameters improved and pregnancy rate increased within 6 months of treatment compared to local intrauterine and antibiotic therapy.
Authors’ contributions: Kravchenko E.N. – developing the concept and design of the study, editing the article; Novitskaya E.L. – collecting and processing of the material; Sabitova N.L. – collecting and processing of the material, writing the text;
Lisitsa E.V. – collecting and processing of the material, statistical data processing, writing the text.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was approved by the Ethical Review Board of the City Clinical Perinatal Center (protocol No. 5 dated 10.05.2024).
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Kravchenko E.N., Novitskaya E.L., Sabitova N.L., Lisitsa E.V. Evaluation of the effectiveness of complex treatment for chronic endometritis resulting in thin endometrium in patients with impaired reproductive function.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (4): 138-144 (in Russian)
https://dx.doi.org/10.18565/aig.2025.7
Keywords
chronic endometritis
thin endometrium
irrigation of the uterus with a cavitated solution
antimicrobial peptides
cytokine therapy
Superlymph
References
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Received 14.01.2025
Accepted 11.04.2025
About the Authors
Elena N. Kravchenko, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology No. 1, Omsk State Medical University,Ministry of Health of Russia, 644099, Russia, Omsk, Lenin str., 12, +7(3812)23-02-93, +7(913)620-81-62, kravchenko.en@mail.ru, https://orcid.org/0000-0001-9481-8812
Elena L. Novitskaya, obstetrician-gynecologist of the highest qualification category, Head of Day Hospital No. 2, City Clinical Perinatal Center,
644010, Russia, Omsk, Mayakovsky str., 65/1, +7(3812)30-59-58, +7(905)922-27-62, fcabhm@bk.ru
Natalya L. Sabitova, obstetrician-gynecologist of the highest qualification category of a Day Hospital, City Clinical Perinatal Center,
644010, Russia, Omsk, Mayakovsky str., 65/1, +7(913)600-63-33, shamilsabitov58@mail.ru
Ekaterina V. Lisitsa, Resident at the Department of Obstetrics and Gynecology No. 1, Omsk State Medical University, Ministry of Health of Russia,
644099, Russia, Omsk, Lenin str., 12, +7(3812)23-02-93, +7(913)157-16-76, kate.lisitsaa@mail.ru
Corresponding author: Elena N. Kravchenko, kravchenko.en@mail.ru
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