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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2024№10
Diagnosis and treatment of chronic...

Diagnosis and treatment of chronic endometritis in women with respiratory tuberculosis

DOI
https://dx.doi.org/10.18565/aig.2024.149

Kayukova S.I., Ochirova S.O., Sinyatkina V.V., Karpina N.L., Uvarova E.V., Mikhaleva L.M.

1) Central Scientific Research Institute of Tuberculosis, Moscow, Russia; 2) N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia; 3) I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia; 4) A.P. Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia; 5) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

In 2022, the incidence of tuberculosis among women in Russia was 18.5 per 100,000 population and this rate is a cause for concern in the current demographic situation. Tuberculosis, as a systemic infectious process, affects the reproductive system. To date, most studies have focused on genital tuberculosis which tends to involve the fallopian tubes. Endometritis (tuberculous and non-tuberculous etiology) has been the subject of a number of separate publications that have lacked a coherent conceptual framework.
Objective: To study the data of the world literature on the problem of chronic endometritis in fertile women with respiratory tuberculosis.
Materials and methods: The article presents the results of the search and analysis of literature sources in international and Russian databases including Google Scholar, PubMed, eLibrary for the period from 2018 (January, February) to 2024 according to the PRISMA international standard.
Results: According to different studies, the incidence of chronic endometritis among fertile women ranges from 8 to 72%; tuberculous endometritis in patients suffering from respiratory tuberculosis varies from 5 to 20%. Pipelle endometrial biopsy followed by a pathomorphological diagnosis and immunohistochemical analysis is currently regarded as the gold standard for diagnosing chronic endometritis. The diagnosis and treatment of chronic endometritis of specific and non-specific etiology in women with respiratory tuberculosis remain poorly studied.
Conclusion: The study of the significant clinical issue of the combination of chronic endometritis and respiratory tuberculosis is relevant for obstetrician-gynecologists and tuberculotherapists, as it contributes to the protection of the reproductive health in women with socially significant infections.

Authors’ contributions: Kayukova S.I. – developing the concept of the study; Ochirova S.O., Sinyatkina V.V. – analysis of the literature; Kayukova S.I., Ochirova S.O. – analysis and summary of the results of the study; Ochirova S.O., Kayukova S.I., Sinyatkina V.V. – writing the text of the manuscript; Kayukova S.I., Karpina N.L., Mikhaleva L.M., Uvarova E.V. – supervision.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was performed within the framework of the basic project of the Center for Diagnostics and Rehabilitation of Respiratory Diseases no. UN FURE-2022-0013 Tuberculosis and Respiratory Diseases – Modern Multimodal Diagnostics and Rehabilitation in Comorbid Conditions.
Acknowledgements: The authors would like to express their gratitude to the doctors of the Pathology Department of the City Clinical Hospital No. 31, Natalia A. Gracheva, MD, PhD, and the Head of the Reference Center, Head of the Clinical and Diagnostic Center of the A.P. Avtsyn Research Institute of Human Morphology, Andrey E. Biryukov, MD, PhD.
For citation: Kayukova S.I., Ochirova S.O., Sinyatkina V.V., Karpina N.L., Uvarova E.V., Mikhaleva L.M. 
Diagnosis and treatment of chronic endometritis in women with respiratory tuberculosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (10): 11-18 (in Russian)
https://dx.doi.org/10.18565/aig.2024.149

Keywords

chronic endometritis
genital tuberculosis
tuberculosis of the reproductive organs
Full text (in Russian)

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Received 27.06.2024

Accepted 04.10.2024

About the Authors

Svetlana I. Kayukova, Dr. Med. Sci., Professor, Pirogov Russian National Research Medical University, Ministry of Health of Russia; Leading Researcher at the Department
of Immunology, Central Research Institute of Tuberculosis, 107564, Russia, Moscow, Yauzskaya Alley, 2, +7(915)396-85-34, kajukovalnp@gmail.com,
https://orcid.org/0000-0002-5233-3515
Svetlana O. Оchirova, PhD student, Central Research Institute of Tuberculosis, 107564, Russia, Moscow, Yauzskaya Alley, 2, +7(926)081-77-64, ochirova-svetlana@rambler.ru, https://orcid.org/0009-0008-8585-5548
Valeria V. Sinyatkina, student, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, 119991, Russia, Moscow, GSP-1, Trubetskaya str., 8-2, +7(966)307-20-02, val.sinyatkina@gmail.com, https://orcid.org/0009-0003-2317-1224
Natalia L. Karpina, Dr. Med. Sci., Head of the Center for Diagnosis and Rehabilitation of Respiratory Diseases, Deputy Director, Central Research Institute of Tuberculosis, 107564, Russia, Moscow, Yauzskaya Alley, 2, +7(499)785-90-26, natalya-karpina@rambler.ru, https://orcid.org/0000-0001-7800-8158
Elena V. Uvarova, Dr. Med. Sci., Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Gynecology of Childhood and Adolescence, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,
117997, Russia, Moscow, Ac. Oparin str., 4, +7(495)531-44-44, elena-uvarova@yandex.ru , https://orcid.org/0000-0002-3105-5640.
Lyudmila M. Mikhaleva, Dr. Med. Sci., Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Laboratory, Director, Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery; Head of the Pathology Department, City Clinical Hospital No.31 named after Academician
G.M. Savelyeva, Moscow Health Department, 119415, Russia, Moscow, Lobachevsky str., 42, +7(499)432-96-53, mikhalevam@yandex.ru,
https://orcid.org/0000-0003-2052-914X
Corresponding author: Svetlana O. Оchirova, ochirova-svetlana@rambler.ru

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