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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2024№10
Diagnosis and treatment of chronic...

Diagnosis and treatment of chronic endometritis in women with respiratory tuberculosis

DOI
https://dx.doi.org/10.18565/aig.2024.149

Kayukova S.I., Ochirova S.O., Sinyatkina V.V., Karpina N.L., Uvarova E.V., Mikhaleva L.M.

1) Central Scientific Research Institute of Tuberculosis, Moscow, Russia; 2) N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia; 3) I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia; 4) A.P. Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia; 5) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

In 2022, the incidence of tuberculosis among women in Russia was 18.5 per 100,000 population and this rate is a cause for concern in the current demographic situation. Tuberculosis, as a systemic infectious process, affects the reproductive system. To date, most studies have focused on genital tuberculosis which tends to involve the fallopian tubes. Endometritis (tuberculous and non-tuberculous etiology) has been the subject of a number of separate publications that have lacked a coherent conceptual framework.
Objective: To study the data of the world literature on the problem of chronic endometritis in fertile women with respiratory tuberculosis.
Materials and methods: The article presents the results of the search and analysis of literature sources in international and Russian databases including Google Scholar, PubMed, eLibrary for the period from 2018 (January, February) to 2024 according to the PRISMA international standard.
Results: According to different studies, the incidence of chronic endometritis among fertile women ranges from 8 to 72%; tuberculous endometritis in patients suffering from respiratory tuberculosis varies from 5 to 20%. Pipelle endometrial biopsy followed by a pathomorphological diagnosis and immunohistochemical analysis is currently regarded as the gold standard for diagnosing chronic endometritis. The diagnosis and treatment of chronic endometritis of specific and non-specific etiology in women with respiratory tuberculosis remain poorly studied.
Conclusion: The study of the significant clinical issue of the combination of chronic endometritis and respiratory tuberculosis is relevant for obstetrician-gynecologists and tuberculotherapists, as it contributes to the protection of the reproductive health in women with socially significant infections.

Authors’ contributions: Kayukova S.I. – developing the concept of the study; Ochirova S.O., Sinyatkina V.V. – analysis of the literature; Kayukova S.I., Ochirova S.O. – analysis and summary of the results of the study; Ochirova S.O., Kayukova S.I., Sinyatkina V.V. – writing the text of the manuscript; Kayukova S.I., Karpina N.L., Mikhaleva L.M., Uvarova E.V. – supervision.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was performed within the framework of the basic project of the Center for Diagnostics and Rehabilitation of Respiratory Diseases no. UN FURE-2022-0013 Tuberculosis and Respiratory Diseases – Modern Multimodal Diagnostics and Rehabilitation in Comorbid Conditions.
Acknowledgements: The authors would like to express their gratitude to the doctors of the Pathology Department of the City Clinical Hospital No. 31, Natalia A. Gracheva, MD, PhD, and the Head of the Reference Center, Head of the Clinical and Diagnostic Center of the A.P. Avtsyn Research Institute of Human Morphology, Andrey E. Biryukov, MD, PhD.
For citation: Kayukova S.I., Ochirova S.O., Sinyatkina V.V., Karpina N.L., Uvarova E.V., Mikhaleva L.M. 
Diagnosis and treatment of chronic endometritis in women with respiratory tuberculosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (10): 11-18 (in Russian)
https://dx.doi.org/10.18565/aig.2024.149

Keywords

chronic endometritis
genital tuberculosis
tuberculosis of the reproductive organs
Full text (in Russian)

References

  1. World Health Organization. Tuberculosis. 2023. Available at: https://www.who.int/ru/news-room/fact-sheets/detail/tuberculosis
  2. Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека. Государственный доклад «О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2022 году». М.; 2023. 368с. [Federal Service for Supervision of Consumer Rights Protection and Human Welfare. State report "On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2022." Moscow; 2023. 368p. (in Russian)].
  3. Kesharwani H., Mohammad S., Pathak P. Tuberculosis in the female genital tract. Cureus. 2022; 14(9): e28708. https://dx.doi.org/10.7759/cureus.28708.
  4. Петров Ю.А., Шелемех К.Е., Чернавский В.В., Арндт И.Г. Нарушение фертильности при генитальном туберкулезе. В кн.: Петров Ю.А., ред. Здоровая мать - здоровое потомство. Сборник материалов внутривузовской научно-практической конференции. Ростов-на-Дону: Ростовский государственный медицинский университет; 2020: 351-8. [Petrov Yu.A., Shelemekh K.E., Chernavskii V.V., Arndt I.G. Fertility disorders in genital tuberculosis. In: Petrov Yu.A., ed. Healthy mother - healthy posterity. A collection of materials of an intra-university scientific and practical conference. Rostov-on-Don: Rostov State Medical University; 2020: 351-8. (in Russian)].
  5. Flores-Lovon K., Soriano-Moreno D.R., Medina-Ramirez S.A., Fernandez-Guzman D., Caira-Chuquineyra B., Fernandez-Morales J. et al. Effects of antituberculosis treatment on pregnancy outcomes in infertile women with genital tuberculosis: a systematic review. BMJ Open. 2023; 13(9): e070456. https://dx.doi.org/10.1136/bmjopen-2022-070456.
  6. Gupta S., Gupta P. Etiopathogenesis, challenges and remedies associated with female genital tuberculosis: potential role of nuclear receptors. Front. Immunol. 2020; 11: 02161. https://dx.doi.org/10.3389/fimmu.2020.02161.
  7. Шахабова Х.Р., Палиева Н.В., Петров Ю.А., Чернавский В.В. Воспаление матки и репродуктивные нарушения у женщин. Главный врач Юга России. 2022; 2: 17-21. [Shakhabova Kh.R., Palieva N.V., Petrov Yu.A., Chernavskii V.V. Inflammation of the uterus and reproductive disorders in women. Glavnyi Vrach Yuga Rossii. 2022; (2): 17-21. (in Russian)].
  8. Kitaya K., Takeuchi T., Mizuta S., Matsubayashi H., Ishikawa T. Endometritis: new time, new concepts. Fertil. Steril. 2018; 110(3): 344-50. https://dx.doi.org/10.1016/j.fertnstert.2018.04.012.
  9. Аполихина И.А., Эфендиева З.Н. Хронический эндометрит. Акушерство и гинекология. 2019; 3(Приложение): 26-8. [Apolikhina I.A., Efendieva Z.N. Chronic endometritis. Obstetrics and Gynecology. 2019; 3(Suppl.): 26-8. (in Russian)].
  10. Шамилова А.М., Ильина И.Ю., Боровкова Е.И., Доброхотова Ю.Э. Хронический эндометрит. Пути улучшения методов диагностики. РМЖ. Мать и дитя. 2021; 4(3): 243-9. [Shamilova A.M., Il’ina I.Yu., Borovkova E.I., Dobrokhotova Yu.E. Chronic endometritis. Towards the improvement of diagnostic methods. Russian Journal of Woman and Child Health. 2021; 4(3): 243-9. (in Russian)]. https://dx.doi.org/10.32364/2618-8430-2021-4-3-243-249.
  11. Оразов М.Р., Михалева Л.М., Семенов П.А. Хронический эндометрит: патогенез, диагностика, лечение и его связь с бесплодием. Клиническая и экспериментальная морфология. 2020; 9(2): 16-25. [Orazov M.R., Mikhaleva L.M., Semenov P.A. Chronic endometritis: pathogenesis, diagnosis, management and associated infertility. Clinical and Experimental Morphology. 2020; 9(2): 16-25. (in Russian)]. https://dx.doi.org/10.31088/CEM2020.9.2.16-25.
  12. Толибова Г.Х., Траль Т.Г. Хронический эндометрит – затянувшаяся дискуссия. Уральский медицинский журнал 2023; 22(2): 142-52. [Tolibova G.Kh., Tral T.G. Chronic endometritis: a protracted discussion. Ural Medical Journal. 2023; 22(2): 142-52. (in Russian)]. https://dx.doi.org/10.52420/2071-5943-2023-22-2-142-152.
  13. Buzzaccarini G., Vitagliano A., Andrisani A., Santarsiero C.M., Cicinelli R., Nardelli C. et al. Chronic endometritis and altered embryo implantation: a unified pathophysiological theory from a literature systematic review. J. Assist. Reprod. Genet. 2020; 37(12): 2897-911. https://dx.doi.org/10.1007/s10815-020-01955-8.
  14. Li J., Li X., Ding J., Zhao J., Chen J., Guan F. et al. Analysis of pregnancy outcomes in patients with recurrent implantation failure complicated with chronic endometritis. Front. Cell Dev. Biol. 2023; 11: 1088586. https://dx.doi.org/10.3389/fcell.2023.1088586.
  15. Ticconi C., Inversetti A., Marraffa S., Campagnolo L., Arthur J., Zambella E. et al. Chronic endometritis and recurrent reproductive failure: a systematic review and meta-analysis. Front. Immunol. 2024; 15: 1427454. https://dx.doi.org/10.3389/fimmu.2024.1427454.
  16. Veiga E.C.A., Soares Junior J.M., Samama M., Ikeda F., Francisco L.S., Sartor A. et al. Chronic endometritis and assisted reproduction: a systematic review and meta-analysis. Rev. Assoc. Med. Bras. 2023; 69(10): e20230792. https://dx.doi.org/10.1590/1806-9282.20230792.
  17. World Health Organization. ICD-11 2022 release “Better health with better information”. 2022. Available at: https://www.who.int/news/item/11-02-2022-icd-11-2022-release
  18. Правительство Российской Федерации. Распоряжение от 31.01.2024 № 200-р. Доступно по: https://publication.pravo.gov.ru/document/0001202402020027 [The Government of the Russian Federation. Order No. 200-r dated 31.01.2024. Available at: https://publication.pravo.gov.ru/document/0001202402020027 (in Russian)].
  19. Yasuo T., Kitaya K. Challenges in clinical diagnosis and management of chronic endometritis. Diagnostics (Basel). 2022; 12(11): 2711. https://dx.doi.org/10.3390/diagnostics12112711.
  20. Singh N., Sethi A. Endometritis - diagnosis, treatment and its impact on fertility - a scoping review. JBRA Assist. Reprod. 2022; 26(3): 538-46. https://dx.doi.org/10.5935/1518-0557.20220015.
  21. Асатурова А.В., Табеева Г.И., Бадлаева А.С., Трегубова А.В. Диагностика хронического эндометрита с помощью оценки плазматических клеток в строме эндометрия: настоящее и будущее. Обзор литературы. Лабораторная и клиническая медицина. Фармация. 2023; 3(4): 49-57. [Asaturova A.V., Tabeeva G.I., Badlaeva A.S., Tregubova A.V. Chronic endoemtritis diagnosis with plasma cells detection: present and future. Review. Laboratory and Clinical Medicine. Pharmacy. 2023; 3(4): 49-57. (in Russian)]. https://dx.doi.org/10.14489/lcmp.2023.04.pp.049-057.
  22. Диомидова В.Н., Захарова О.В., Журавлева Н.В., Самойлова А.А., Виноградова В.С. Современный подход к применению ультразвуковой эластографии при вторичном женском бесплодии. Проблемы репродукции. 2022; 28(6): 139‑46. [Diomidova V.N., Zakharova O.V., Zhuravleva N.V., Samoilova A.A., Vinogradova V.S. Modern approach to the use of ultrasound elastography in secondary female infertility. Russian Journal of Human Reproduction. 2022; 28(6): 139-46. (in Russian)]. https://dx.doi.org/10.17116/repro202228061139.
  23. Министерство здравоохранения Российской Федерации. Клинические рекомендации. Воспалительные болезни женских тазовых органов. 2021. [Ministry of Health of the Russian Federation. Clinical guidelines. Inflammatory diseases of the female pelvic organs. 2021. (in Russian)].
  24. Савельева Г.М., Михалев С.А., Коноплянников А.Г., Михалева Л.М., Бабиченко И.И., Болтовская М.Н. Хронический эндометрит - показание для прегравидарной подготовки. Клиническая практика. 2018; 9(2): 36-41. [Savelyeva G.M., Mikhalev S.A., Konoplyannikov A.G., Mikhaleva L.M., Babichenko I.I., Boltovskaya M.N. Chronic endometritis is an indication for the pregravid preparation. Clinical Practice. 2018; 9(2): 36-41. (in Russian)]. https://dx.doi.org/10.17816/clinpract 092 36-41.
  25. Zeng S., Liu X., Liu D., Song W. Research update for the immune microenvironment of chronic endometritis. J. Reprod. Immunol. 2022; 152: 103637. https://dx.doi.org/10.1016/j.jri.2022.103637.
  26. Cheng X., Huang Z., Xiao Z., Bai Y. Does antibiotic therapy for chronic endometritis improve clinical outcomes of patients with recurrent implantation failure in subsequent IVF cycles? A systematic review and meta-analysis. J. Assist. Reprod. Genet. 2022; 39(8): 1797-813. https://dx.doi.org/10.1007/s10815-022-02558-1.
  27. Santoro A., Travaglino A., Inzani F., Angelico G., Raffone A., Maruotti G.M. et al. The role of plasma cells as a marker of chronic endometritis: a systematic review and meta-analysis. Biomedicines. 2023; 11(6): 1714. https://dx.doi.org/10.3390/biomedicines11061714.
  28. Puente E., Alonso L., Laganà A.S., Ghezzi F., Casarin J., Carugno J. Chronic endometritis: old problem, novel insights and future challenges. Int. J. Fertil. Steril. 2020; 13(4): 250-6. https://dx.doi.org/10.22074/ijfs.2020.5779.
  29. Оразов М.Р., Михалева Л.М., Силантьева Е.С., Семенов П.А., Орехов Р.Е., Лагутина Е.В. Патент RU 2 748 191 C1. Способ определения степени выраженности хронического эндометрита у женщин с маточным фактором бесплодия после неудачного экстракорпорального оплодотворения в анамнезе (варианты). Заявка: 21.01.2021. Опубликовано: 20.05.2021. [Orazov M.R., Mikhaleva L.M., Silant’eva E.S., Semenov P.A., Orekhov R.E., Lagutina E.V. Patent RU 2 748 191 C1. Method for determining degree of severity of chronic endometritis in women with uterine infertility factor after unsuccessful in vitro fertilization in history (variants). Declared 21.01.2021. Published 20.05.2021. (in Russian)].
  30. Tsonis O., Gkrozou F., Dimitriou E., Barmpalia Z., Tsonis K., Vatopoulou A. et al. Hysteroscopic features suggestive of chronic endometritis: a systematic review. Hum. Fertil. (Camb.). 2023; 26(6): 1530-43. https://dx.doi.org/10.1080/14647273.2023.2265155.
  31. Оразов М.Р., Михалева Л.М., Пойманова О.Ф. Гистероскопическая диагностика полипов эндометрия, ассоциированных с хроническим эндометритом. Акушерство и гинекология: новости, мнения, обучение. 2024; 12(Спецвыпуск): 141-7. [Orazov M.R., Mikhaleva L.M., Poimanova O.F. Hysteroscopic diagnosis of endometrial polyps associated with chronic endometritis. Obstetrics and Gynecology: News, Opinions, Training. 2024; 12(Suppl.): 141-7. https://dx.doi.org/10.33029/2303-9698-2024-12-suppl-141-147.
  32. Kato H., Yamagishi Y., Hagihara M., Hirai J., Asai N., Shibata Y. et al. Systematic review and meta-analysis for impacts of oral antibiotic treatment on pregnancy outcomes in chronic endometritis patients. J. Infect. Chemother. 2022; 28(5): 610-5. https://dx.doi.org/10.1016/j.jiac.2022.01.001.
  33. Vitagliano A., Saccardi C., Noventa M., Di Spiezio Sardo A., Saccone G., Cicinelli E. et al. Effects of chronic endometritis therapy on in vitro fertilization outcome in women with repeated implantation failure: a systematic review and meta-analysis. Fertil. Steril. 2018; 110(1): 103-12.e1. https://dx.doi.org/10.1016/j.fertnstert.2018.03.017.
  34. Sfakianoudis K., Simopoulou M., Nitsos N., Lazaros L., Rapani A., Pantou A. et al. Successful implantation and live birth following autologous platelet-rich plasma treatment for a patient with recurrent implantation failure and chronic endometritis. In Vivo. 2019; 33(2): 515-21. https://dx.doi.org/10.21873/invivo.11504.
  35. Плужникова Т.А., Алябьева Е.А., Самарская И.В. Оценка эффективности цитокинотерапии в лечении хронического эндометрита у женщин с репродуктивными потерями. РМЖ. Мать и дитя. 2023; 6(2): 88-94. [Pluzhnikova T.A., Alyabeva E.A., Samarskaya I.V. Analysis of the efficacy of cytokine therapy in the treatment of chronic endometritis in women with reproductive losses. Russian Journal of Woman and Child Health. 2023; 6(2): 88-94 (in Russian)]. https://dx.doi.org/10.32364/2618-8430-2023-6-2-88-94.
  36. Борисевич О.О., Фесюн А.Д., Котенко Н.В. Применение физических факторов при лечении хронического эндометрита: научный обзор. Вестник восстановительной медицины. 2023; 22(1): 110-6. [Borisevich O.O., Fesyun A.D., Kotenko N.V. Application of physical factors in the chronic endometritis treatment: a review. Bulletin of Rehabilitation Medicine. 2023; 22(1): 110-6. (in Russian)]. https://dx.doi.org/10.38025/2078-1962-2023-22-1-110-116.
  37. Оразов М.Р., Михалева Л.М., Семенов П.А., Орехов Р.Е., Лагутина Е.В. Эффективность лечения хронического эндометрита у женщин с неудачами имплантации в анамнезе. Трудный пациент. 2020; 18(8-9): 7-12. [Orazov M.R., Mikhaleva L.M., Semenov P.A., Orekhov R.E., Lagutina E.V. The effectiveness of chronic endometritis treatment in women with a history of implantation failures. Difficult Patient. 2020; 18(8-9): 7-12. (in Russian)]. https://dx.doi.org/10.24411/2074-1995-2020-10053.
  38. Ahmed M.A.E., Mohammed A.A.A., Ilesanmi A.O., Aimakhu C.O., Bakhiet A.O., Hamad S.B.M. Female genital tuberculosis among infertile women and its contributions to primary and secondary infertility: a systematic review and meta-analysis. Sultan Qaboos Univ. Med. J. 2022; 22(3): 314-24. https://dx.doi.org/10.18295/squmj.1.2022.003.
  39. Vijay A., Tiwari N., Sharma A., Pandey G. Correlation of female genital tuberculosis and infertility: a comprehensive systematic review, meta-analysis, and female genital tuberculosis infertility pathway analysis. J. Midlife Health. 2023; 14(3): 165-9. https://dx.doi.org/10.4103/jmh.jmh_151_23.
  40. Петров Ю.А., Шелемех К.Е. Генитальный туберкулез - заболевание, требующее выявления и лечения. Главврач Юга России. 2020; 5: 38-41. [Petrov Yu.A., Shelemekh K.E. Genital tuberculosis - a disease requiring identification and treatment. Glavnyi Vrach Yuga Rossii. 2020; (5): 38-41. (in Russian)].
  41. Министерство здравоохранения Российской Федерации. Клинические рекомендации. Туберкулез у взрослых. 2024. [Ministry of Health of the Russian Federation. Clinical guidelines. Tuberculosis in adults. 2024. (in Russian)].
  42. Савельева Г.М., Сухих Г.Т., Серов В.Н., Радзинский В.Е., Манухин И.Б., ред. Гинекология. Национальное руководство. 2-е изд. М.: ГЭОТАР-Медиа; 2020. 1008с. [Savelyeva G.M., Sukhikh G.T., Serov V.N., Radzinsky V.E., Manukhin I.B., eds. Gynecology. National guide. 2nd ed. Moscow: GEOTAR-Media; 2020. 1008p. (in Russian)].
  43. Колачевская Е.Н. Туберкулез женских половых органов. Серия: Библиотека практикующего врача. М.: Медицина; 1975. 212c. [Kolachevskaya E.N. Tuberculosis of the female genital organs. Series: Practitioner's Library. Moscow: Medicine; 1975. 212p. (in Russian)].
  44. Кульчавеня Е.В., Краснов В.А. Избранные вопросы фтизиоурологии. Новосибирск: Наука; 2010. 142c. [Kulchavenya E.V., Krasnov V.A. Selected issues of phthisiourology. Novosibirsk: Nauka; 2010. 142p. (in Russian)].
  45. Sharma J.B., Sharma E., Sharma S., Dharmendra S. Female genital tuberculosis: revisited. Indian J. Med. Res. 2018; 148(Suppl.): S71-S83. https://dx.doi.org/10.4103/ijmr.IJMR_648_18.
  46. Еременко Е.П., Бородулина Е.А., Сергеева И.А., Кудлай Д.А., Бородулин Б.Е. Рекомбинантный in vitro тест T-SPOT.TB как метод скрининга для ранней диагностики туберкулезной инфекции. Туберкулез и болезни легких. 2020; 98(4): 48-52. [Eremenko E.P., Borodulina E.А., Sergeeva I.А., Kudlai D.А., Borodulin B.E. Recombinant in vitro test T-SPOT.TB as a screening method for early diagnosis of tuberculosis infection. Tuberculosis and Lung Diseases. 2020; 98(4): 48-52. (in Russian)]. https://dx.doi.org/10.21292/2075-1230-2020-98-4-48-52.
  47. Старшинова А.А., Довгалюк И.Ф., Зинченко Ю.С., Кудлай Д.А., Яблонский П.К. Иммунодиагностика туберкулеза сегодня: современные иммунологические тесты и дифференцированный подход к их применению в практике. Практическая пульмонология. 2019; 2: 28-32. [Starshinova A.A., Dovgalyuk I.F., Zinchenko Yu.S., Kudlai D.A., Yablonskii P.K. Immunodiagnosis of tuberculosis: modern immunological tests and differentiated approach to their use in practice. Practical Pulmonology. 2019; (2): 28-32. (in Russian)].
  48. Tzelios C., Neuhausser W.M., Ryley D., Vo N., Hurtado R.M., Nathavitharana R.R. Female genital tuberculosis. Open Forum Infect. Dis. 2022; 9(11): ofac543. https://dx.doi.org/10.1093/ofid/ofac543.
  49. Tjahyadi D., Ropii B., Tjandraprawira K.D., Parwati I., Djuwantono T., Permadi W. et al. Female genital tuberculosis: clinical presentation, current diagnosis, and treatment. Infect. Dis. Obstet. Gynecol. 2022; 2022: 3548190. https://dx.doi.org/10.1155/2022/3548190.
  50. Wang Y., Shao R., He C., Chen L. Emerging progress on diagnosis and treatment of female genital tuberculosis. J. Int. Med. Res. 2021; 49(5): 3000605211014999. https://dx.doi.org/10.1177/03000605211014999.

Received 27.06.2024

Accepted 04.10.2024

About the Authors

Svetlana I. Kayukova, Dr. Med. Sci., Professor, Pirogov Russian National Research Medical University, Ministry of Health of Russia; Leading Researcher at the Department
of Immunology, Central Research Institute of Tuberculosis, 107564, Russia, Moscow, Yauzskaya Alley, 2, +7(915)396-85-34, kajukovalnp@gmail.com,
https://orcid.org/0000-0002-5233-3515
Svetlana O. Оchirova, PhD student, Central Research Institute of Tuberculosis, 107564, Russia, Moscow, Yauzskaya Alley, 2, +7(926)081-77-64, ochirova-svetlana@rambler.ru, https://orcid.org/0009-0008-8585-5548
Valeria V. Sinyatkina, student, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, 119991, Russia, Moscow, GSP-1, Trubetskaya str., 8-2, +7(966)307-20-02, val.sinyatkina@gmail.com, https://orcid.org/0009-0003-2317-1224
Natalia L. Karpina, Dr. Med. Sci., Head of the Center for Diagnosis and Rehabilitation of Respiratory Diseases, Deputy Director, Central Research Institute of Tuberculosis, 107564, Russia, Moscow, Yauzskaya Alley, 2, +7(499)785-90-26, natalya-karpina@rambler.ru, https://orcid.org/0000-0001-7800-8158
Elena V. Uvarova, Dr. Med. Sci., Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Gynecology of Childhood and Adolescence, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia,
117997, Russia, Moscow, Ac. Oparin str., 4, +7(495)531-44-44, elena-uvarova@yandex.ru , https://orcid.org/0000-0002-3105-5640.
Lyudmila M. Mikhaleva, Dr. Med. Sci., Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Laboratory, Director, Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery; Head of the Pathology Department, City Clinical Hospital No.31 named after Academician
G.M. Savelyeva, Moscow Health Department, 119415, Russia, Moscow, Lobachevsky str., 42, +7(499)432-96-53, mikhalevam@yandex.ru,
https://orcid.org/0000-0003-2052-914X
Corresponding author: Svetlana O. Оchirova, ochirova-svetlana@rambler.ru

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