Feasibility of objective assessment of the progress of preterm labor at different gestational ages

Novikova V.A., Cherepakhin E.P., Glebova E.V., Nikonov M.A., Tomashevsky D.V.

1 Peoples’ Friendship University of Russia, Moscow, Russia; 2 Perinatal Center, Territorial Children’s Clinical Hospital, Krasnodar, Russia
Objective. To investigate the feasibility of an objective assessment of the progress of preterm labor at different gestational ages. Subjects and methods. This prospective, nonrandomized study comprised 150 women with premature births at various gestational ages and 50 control women with full-term births. The study estimated and differentiated objective factors for predicting preterm labor within 24 hours. Results. Based on the discriminant analysis, the predictive significance of various parameters for predicting preterm labor was estimated depending on the gestational age. The risk of childbirth with extensor presentation of the fetal head is established in very early, early and preterm labor. Conclusion. To assess the risk of preterm labor, ultrasonic measurements of cervical vascularization index and the fetal head–perineum distance need to be done in addition to routine diagnostic evaluation. In very early, early and premature labor with the extensor presentation of the fetal head, the risks of vaginal birth should be considered together with a neonatologist.

Keywords

premature birth
cervical vascularization
extensor insertion of the fetal head

References

1. Сухих Г.Т., Тетруашвили Н.К., Трофимов Д.Ю., Ким Л.В., Барков И.Ю., Шубина Е.С., Парсаданян Н.Г., Федорова Н.И., Гольцов А.Ю., Александрова Н.В. Неинвазивный пренатальный ДНК-скрининг методом высокопроизводительного секвенирования у беременных с акушерской патологией. Доктор.Ру. 2017; 3: 11-5. [Sukhikh GT, Tetruashvili NK, Trofimov D.Yu., Kim LV, Barkov I.Yu., Shubina E.S., Parsadanyan N.G., Fedorova N.I., Goltsov A.Yu., Aleksandrova N.V. Noninvasive prenatal DNA screening by high-throughput sequencing in pregnant women with obstetric pathology. Doctor.Ru. 2017; 3: 11-5. (in Russian)]

2. Айламазян Э.К., Кузьминых Т.У. Дискуссионные вопросы преждевременных родов. Журнал акушерства и женских болезней. 2013; 62(4): 97-105. [Ailamazyan, E.K. Discussion of preterm labor. ZHurnal akusherstva i zhenskih boleznej/Journal of Obstetrics and Women’s Diseases. 2013: 62(4): 97-105. (in Russian)]

3. Romero R., Chaemsaithong P., Chaiyasit N., Docheva N., Dong Z., Kim C.J., et al. CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor. Am. J. Reprod. Immunol. 2017; 78(1): 1-62. e12685.

4. Булатова Ю.С., Тетруашвили Н.К., Высоких М.Ю. Провоспалительные факторы митохондриального происхождения в патогенезе привычных выкидышей и ранних преждевременных родов. Акушерство и гинекология. 2017; 8: 5-9. http://dx.doi.org/10.18565/aig.2017.8.5-9 [Bulatova Yu.S., Tetruashvili N.K., Vysokikh M.Yu. Proinflammatory factors of mitochondrial origin in the pathogenesis of recurrent miscarriages and early preterm births. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (8): 5-9. (in Russian) http://dx.doi.org/10.18565/aig.2017.8.5-9]

5. Tarca A.L., Fitzgerald W., Chaemsaithong P., Xu Z., Hassan S.S., Grivel J.C. et al. The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery. Am. J. Reprod. Immunol. 2017; 78(3): 1-56. e12686.

6. Watson H.A., Carter J., Seed P.T., Tribe R.M., Shennan A.H. The QUiPP App: a safe alternative to a treat-all strategy for threatened preterm labor. Ultrasound Obstet. Gynecol. 2017; 50(3): 342-6.

7. Серова О.Ф., Чернигова И.В., Седая Л.В., Шутикова Н.В. Анализ перинатальных исходов при очень ранних преждевременных родах. Акушерство и гинекология. 2015; 4: 32-6. [Serova O.F., Chernigova I.V., Sedaya L.V., Shutikova N.V. Analysis of perinatal outcomes of very early premature birth. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2015; (4): 32-36. (in Russian)]

8. Фаткуллин И.Ф., Фаткуллин Ф.И., Мунавирова А.А., Исламова Л.Х., Ахметгалиев А.Р., Шайхетдинова А.Т. Опыт применения блокатора окситоциновых рецепторов при начавшихся преждевременных родах. Акушерство и гинекология. 2016; 6: 73-7. https://dx.doi.org/10.18565/aig.2016.6.73-77 [Fatkullin I.F., Fatkullin F.I., Munavirova A.A., Islamova L.Kh., Akhmetgaliev A.R., Shaikhetdinova A.T. Experience with oxytocin receptor antagonist for incipient preterm labor. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2016; (6): 73-77. https://dx.doi.org/10.18565/aig.2016.6.73-77]

9. Iams J.D., Goldenberg R.L., Meis P.J., Mercer B.M., Moawad A., Das A. et al. The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network. N. Engl. J. Med. 1996; 334(9): 567-72.

10. Тетруашвили Н.К., Ким Л.В., Парсаданян Н.Г., Федорова Н.И., Барков И.Ю., Шубина Е.С., Трофимов Д.Ю. Неинвазивный пренатальный ДНК-тест в качестве скрининговой методики у женщин различных групп риска: взгляд на проблему. Акушерство и гинекология. 2016; 8: 24-8. https://dx.doi.org/10.18565/aig.2016.8.24-28 [Tetruashvili N.K., Kim L.V., Parsadanyan N.G., Fedorova N.I., Barkov I.Yu., Shubina E.S., Trofimov D.Yu. Noninvasive prenatal DNA test as a screening procedure for women from different risk groups: A view on the problem. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2016; (8): 24-28. (in Russian) https://dx.doi.org/10.18565/aig.2016.8.24-28]

11. Lee K.A., Chang M.H., Park M.H., Park H., Ha E.H., Park E.A., Kim Y.J. A model for prediction of spontaneous preterm birth in asymptomatic women. J. Womens Health (Larchmt). 2011; 20(12): 1825-31.

12. Borg F., Gravino G., Schembri-Wismayer P., Calleja-Agius J. Prediction of preterm birth. Minerva Ginecol. 2013; 65(3): 345-60.

13. Sananès N., Langer B., Gaudineau A., Kutnahorsky R., Aissi G., Fritz G. et al. Prediction of spontaneous preterm delivery in singleton pregnancies: where are we and where are we going? A review of literature. J. Obstet. Gynaecol. 2014; 34(6): 457-61.

14. Chan Ronna L. Biochemical markers of spontaneous preterm birth in asymptomatic women. Biomed. Res. Int. 2014; 2014: 164081.

15. Barbera A.F., Pombar X., Perugino G., Lezotte D.C., Hobbins J.C. A new method to assess fetal head descent in labor with transperineal. Ultrasound Obstet. Gynecol. 2009; 33(3): 313-9.

16. Клинические рекомендации «Преждевременные роды». Письмо Министерства здравоохранения РФ от 17.12.2013 г. № 15–4/10/2–9480. Доступно по: http://www.garant.ru/products/ipo/prime/doc/71137478/ [Clinical recommendations “Premature birth” (letter of the Ministry of Health of the Russian Federation dated 17.12.2013 No. 15-4 / 10 / 2-9480). Available at: http://www.garant.ru/products/ipo/prime/doc/71137478/ (in Russian)]

17. Организация медицинской эвакуации беременных женщин, рожениц и родильниц при преждевременных родах. Клинические рекомендации (Протокол лечения). Письмо Министерства здравоохранения РФ от 2 октября 2015 г. № 15-4/10/2-5802. Доступно по: http://www.garant.ru/products/ipo/prime/doc/71137474/ [Organization of medical evacuation of pregnant women, parturient women and puerperas with preterm delivery (Clinical Protocol) (2015). Available at: http://www.garant.ru/products/ipo/prime/doc/71137474/ (in Russian)]

18. Приказ Министерства здравоохранения Краснодарского края от 13.12.2016г № 6363. О внесении изменений в приказ Министерства здравоохранения Краснодарского края от 29.04.2014г № 1994 «Об оказании медицинской помощи по профилю «акушерство и гинекология (за исключением использования вспомогательных репродуктивных технологий)» в Краснодарском крае». Доступно по: http://www.minzdravkk.ru/pages/bankdocs/detail.php?ELEMENT_ID=19385 [Order of the Ministry of Health of the Krasnodar Krai of December 13, 2016 No. 6363 on the introduction of amendments to the order of the Ministry of Health of the Krasnodar Territory of April 29, 2014 No. 1994 on the provision of medical assistance on the profile of obstetrics and gynecology (excluding the use of assisted reproductive technologies) in the Krasnodar Territory. (in Russian)]

19. Халафян А.А. Statistica 6. Статистический анализ данных. М.: БИНОМ-Пресс; 2007. 512с. [Halafyan A.A. Statistica 6. Statistical analysis of data. Moscow: Binom-press; 2007. 512p. (in Russian)]

Received 02.10.2017

Accepted 27.10.2017

About the Authors

Vladislava A. Novikova, MD, Professor of the Department of Obstetrics and Gynecology with a course of perinatology, Peoples’ Friendship University of Russia.
117198, Russia, Moscow, Miklukho-Maklaya str. 6. Tel.: +78612220114. E-mail: vladislavan@mail.ru
Evgeny P. Cherepakhin, MD, obstetrician-gynecologist of the maternity department, Perinatal Center, Territorial Children’s Clinical Hospital.
350063, Russia, Krasnodar, Sedina str. 4. Tel.: +78612220114. E-mail: inbox@dkkb-kk.ru
Evgenia V. Glebova, ultrasound diagnostician, Perinatal Center, Territorial Children’s Clinical Hospital. 350007, Russia, Krasnodar, Sq. Pobedy 1. E-mail: inbox@dkkb-kk.ru
Maxim A. Nikonov, ultrasound diagnostician, Perinatal Center, Territorial Children’s Clinical Hospital. 350007, Russia, Krasnodar, Sq. Pobedy 1. E-mail: inbox@dkkb-kk.ru
Dmitry V. Tomashevsky, deputy chief doctor for perinatal care, Perinatal Center, Territorial Children’s Clinical Hospital.
350007, Russia, Krasnodar, Sq. Pobedy 1. E-mail: inbox@dkkb-kk.ru

For citations: Novikova V.A., Cherepakhin E.P., Glebova E.V., Nikonov M.A., Tomashevskii D.V. Feasibility of objective assessment of the progress of preterm labor at different gestational ages. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (6): 25-30. (in Russian)
https://dx.doi.org/10.18565/aig.2018.6.25-30

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.