Possibilities of the biologically active complex of phytopreparations in the correction of menopausal disorders
Yashchuk A.G., Dautova L.A., Shaikhutdinova O.V., Muslimova L.R., Berg P.A., Berg E.A., Nasyrova S.F., Kizko I.A., Nazyrova A.G.
Objective: To conduct a comparative assessment of the effectiveness of a biologically active complex of phytopreparations and menopausal hormone therapy (MHT) in the treatment of the climacteric syndrome (CS).
Materials and methods: This was a prospective analysis of the effectiveness of using the biologically active complex of phytopreparations NOW Menopause Support 560 mg and MHT in the treatment of CS in women 6 months after receiving therapy. Group 1 included 50 women with CS who received a phytopreparation made on the basis of soy isoflavonoids, cimicifuga rhizome, and red clover isoflavones. Group 2 included 42 patients who received systemic MHT.
Results: According to the Greene Climacteric Scale, the emotional state significantly improved (10.0 (8.0; 14.0) scores) in the group receiving systemic MHT after 6 months from the beginning of therapy, but it was worse than in the other group (p=0.044). The somatic condition effectively improved in the group receiving MHT (3.0 (3.0; 6.0) scores), however it was not different from the condition of women in the group receiving phytopreparations after 6 months of therapy (3.0 (3.0; 6.0) scores), p=0.233. Vasomotor symptom status significantly improved (p<0.001) in both groups after 6 months of treatment. It was assessed as 3.0 (2.0; 5.0) scores in the group of patients after taking MHT and it differed from the group receiving phytopreparations which was 1.0 (1.0; 3.0) scores (p=0.032); it was associated with the presence of milder forms of vasomotor manifestations of CS in the group receiving phytopreparations.
Conclusion: The treatment of CS with phytopreparations and systemic MHT showed high effectiveness. The phytopreparation made on the basis of soy isoflavonoids, cimicifuga rhizome, red clover isoflavone shows positive results in the treatment of the whole spectrum of menopausal disorders, but it can be used with greater benefit for women with moderate severity of symptoms, where the dominant symptoms are somatic and emotional manifestations.
Authors’ contributions: Yashchuk A.G. – development of the study concept, editing the text, approval of the final version of the article; Dautova L.A. – development of the study design, collecting the material, approval of the final version of the article; Shaikhutdinova O.V., Muslimova L.R., Nasyrova S.F., Kizko I.A., Nazyrova A.G. – collecting the material, editing the text; Berg P.A. – writing the article, statistical processing of the data, collecting the material; Berg E.A. – collecting the material, statistical processing of the data, editing the text.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was approved by the Ethical Review Board of the Bashkir State Medical University, Ministry of Health of Russia.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Yashchuk A.G., Dautova L.A., Shaikhutdinova O.V., Muslimova L.R., Berg P.A., Berg E.A., Nasyrova S.F., Kizko I.A., Nazyrova A.G. Possibilities of the biologically active complex of phytopreparations in the correction of menopausal disorders.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (6): 124-132 (in Russian)
https://dx.doi.org/10.18565/aig.2024.127
Keywords
phytoestrogens
menopause
menopausal hormone therapy
menopausal syndrome
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Received 27.05.2024
Accepted 11.06.2024
About the Authors
Alfiya G. Yashchuk, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology No. 2, Bashkir State Medical University, Ministry of Health of Russia, 450008, Russia, Ufa, Lenin str., 3, +73472649650, alfiya_galimovna@mail.ru, https://orcid.org/0000-0003-2645-1662Liliana A. Dautova, PhD, Associate Professor at the Department of Obstetrics and Gynecology No. 2, Bashkir State Medical University, Ministry of Health of Russia,
450008, Russia, Ufa, Lenin str., 3, +79177556262, lili.d5@yandex.ru, https://orcid.org/0000-0002-8281-5515
Olga V. Shaikhutdinova, obstetrician-gynecologist, Chief Physician, City Clinical Hospital No. 5, 450005, Russia, Ufa, Parkhomenko str., 93, +73472649650, p.a.berg@mail.ru, https://orcid.org/0009-0009-2721-4440
Leisan R. Muslimova, Head of Antenatal Clinic, City Clinical Hospital No. 5 450005, Russia, Ufa, Parkhomenko str., 93, +73472649650, p.a.berg@mail.ru,
https://orcid.org/0009-0009-2782-541X
Polina A. Berg, Teaching Assistant, Department of Obstetrics and Gynecology No. 2, Bashkir State Medical University, Ministry of Health of Russia, 450008, Russia, Ufa,
Lenin str., 3, +79373203818, p.a.berg@mail.ru, https://orcid.org/0000-0001-5266-0412
Edvard A. Berg, PhD, Associate Professor at the Department of Obstetrics and Gynecology No. 2, Bashkir State Medical University, Ministry of Health of Russia,
450008, Russia, Ufa, Lenin str., 3, +79273379003, nucleardeer@gmail.com; https://orcid.org/0000-0002-2028-7796
Svetlana F. Nasyrova, PhD, Associate Professor at the Department of Obstetrics and Gynecology No. 2, Bashkir State Medical University, Ministry of Health of Russia, 450008, Russia, Ufa, Lenin str., 3, +79196154652, ufa863@mail.ru, https://orcid.org/0000-0002-2313-7232
Irina A. Kizko, obstetrician-gynecologist, Chief Physician, Anti-aging Medical Clinic GeN, 450006, Russia, Ufa, Krasnodonskaya str., 3, +79373203818,
nucleardeer@gmail.com, https://orcid.org/0009-0004-7290-9122
Alsu G. Nazyrova, PhD, obstetrician-gynecologist, Deputy General Director for Medical Issues, Anti-aging Medical Clinic GeN, 450006, Russia, Ufa, Krasnodonskaya str., 3, +79373203818, nucleardeer@gmail.com, https://orcid.org/0009-0000-7129-9298
Corresponding author: Polina A. Berg, p.a.berg@mail.ru
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