The possibility of neoplastic transformation of ovarian endometriosis
Objective. To investigate the signs of neoplastic transformation of the epithelium in the foci of ovarian endometriosis (OE).Gromova T.A., Sheshukova N.A., Bolshakova O.V., Zairatyants O.V., Levakov S.A., Fedotov, E.V.
Material and methods. Histological and immunohistochemical examinations were used to study 78 and 35 OE cases, respectively, and 8 adenocarcinomas. Anti-Ki-67, anti-Bcl-2, anti-p53, and anti-hepatocyte nuclear factor-1β (HNF-1ß) antibodies were employed.
Results. The epithelium of endometrioid cyst walls showed papillary syncytial changes (39.7%), metaplasia with clear cytoplasm сells (15.4%), and epithelial atypia with a low-to-relatively low Ki-67 and Bcl-2 expression and with a low p53 expression (41.0%). The expression of HNF-1β in the foci with and without atypia was revealed in 94.7 and 56.3% of cases, respectively; it was detected only in clear cell adenocarcinomas.
Conclusion. HNF-1ß hyperexpression suggests the adaptive nature and histogenetic relationship of OE to clear cell tumors of the ovary.
Keywords
ovarian endometriosis
epithelial atypia of ovarian endometriosis
anti-hepatocyte nuclear factor-1β (HNF-1β)
clear cell adenocarcinoma of the ovary
Supplementary Materials
- Table №1. Characteristics of diagnostic oncomarkers in patients prior to surgery
- Table №2. Results of immunohistochemical analysis of endometriotic lesions and ovarian adenocarcinomas (М±σ)
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Received 09.06.2017
Accepted 23.06.2017
About the Authors
Gromova Tatyana Aleksandrovna, post-graduate student of the Department of Obstetrics and Gynecology of the Faculty of Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia. 119991, Russia, Moscow, Trubetskaya str. 8, bld. 2. Tel.: +74956091400. E-mail: tgromova928@yandex.ruSheshukova Natalia Alekseevna, MD, Professor of the Department of Obstetrics and Gynecology of the Faculty of Physiology, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia. 119991, Russia, Moscow, Trubetskaya str. 8, bld. 2. Tel.: +74956091400. E-mail: dr.sheshukova@mail.ru
Bolshakova Olesya Viktorovna, Candidate of Medical Sciences, Head of the gynecological department, Bakhrushins Brothers City Clinical Hospital, Moscow Healthcare Department. 107014, Russia, Moscow, Stromynka str. 7. Tel.: +74992682426
Zayratyants Oleg Vadimovich, MD, professor, head of the Department of Pathological Anatomy, A.I. Evdokimov Moscow State University of Medicine and Dentistry,
Ministry of Health of Russia; chief pathologist of the Moscow Healthcare Department.
127473, Russia, Moscow, Delegatskaya str. 20, bld. 1. Tel.: +74956096700. E-mail: ovzair@mail.ru
Levakov Sergey Alexandrovich, MD, Professor, Head of the Department of Obstetrics and Gynecology of the Medical Faculty, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia. 119991, Russia, Moscow, Trubetskaya str. 8, bld. 2. Tel.: +74956091400. E-mail: levakoff@yandex.ru
Fedotov Evgeniy Viktorovich, Candidate of Medical Science, Head of the pathoanatomical department, A.K. Eramishantsev City Clinical Hospital, Moscow Healthcare Department. 129327, Russia, Moscow, Lenskaya str. 15. Tel.: +74999400430
For citations: Gromova T.A., Sheshukova N.A., Bolshakova O.V., Zairatyants O.V., Levakov S.A. Fedotov, E.V. The possibility of neoplastic transformation of ovarian endometriosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (3): 96-101. (in Russian)
https://dx.doi.org/10.18565/aig.2018.3.96-101
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