Experience of anti-relapse therapy for ovarian endometriosis

Levakov S.A., Budanov P.V., Gromova T.A., Yurova M.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Objective. To evaluate the efficacy of a gonadotropin-releasing hormone (GnRH) agonist (Buserelin depot) in reducing the recurrence rate of ovarian endometriosis after surgery.
Subjects and methods. A total of 147 patients with a verified diagnosis of ovarian endometriosis were examined. The inclusion criterion was also the patients’ reproductive age: the latter ranging from 27 to 35 years was preponderant in the study group; and the mean age of the patients was 31.76±5.84 years. The exclusion criterion was concomitant genital diseases.
Results. The use of Buserelin depot did not result in a decrease in anti-Müllerian hormone levels. That also showed a 4.1-fold reduction in the recurrence rate of ovarian endometriosis in the first year after surgery.
Conclusion. It is necessary to perform anti-relapse therapy using GnRH agonists (buserelin-depot) after surgical treatment for ovarian endometriosis. The frequency of adverse events was rare and did not exceed 6.25%.

Keywords

ovarian endometriosis
Buserelin
recurrences
ovarian reserve
side effects

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Received 30.11.2018

Accepted 07.12.2018

About the Authors

Levakov, Sergey A., MD, professor, head of the Department of Obstetrics and Gynecology, Faculty of Medicine of the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
119991, Russia, Moscow, Trubetskaya str. 8-2. Tel.: +79255063144. E-mail: levakoff@yandex.ru
Budanov, Pavel V., MD, professor of the Department of Obstetrics and Gynecology, Faculty of Medicine of the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
119991, Russia, Moscow, Trubetskaya str. 8-2. Тel.: +74997823045. E-mail: pbumer@mail.ru
Gromova, Tatyana A., postgraduate student, Department of Obstetrics and Gynecology, Faculty of Medicine of the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
119991, Russia, Moscow, Trubetskaya str. 8-2. Тel.: +74997823045
Yurova, Maria V., student of the faculty of medicine of the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
119991, Russia, Moscow, Trubetskaya str. 8-2. Тel.: +74997823045

For citations: Levakov S.A., Budanov P.V., Gromova T.A., Yurova M.V. Experience of anti-relapse therapy for ovarian endometriosis. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (1): 133-38. (in Russian)
http://dx.doi.org/10.18565/aig.2019.1.133-138

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