Impact of telomere length and telomerase activity on the outcomes of assisted reproductive technology programs
This review describes the importance of telomeres and telomerase for human reproduction. It considers the impact of concomitant diseases on telomere length in females and males. It also describes telomerase activity and telomere length at different stages of ontogenesis: from spermatogenesis and oogenesis to subsequent embryonic development. There is information from various studies conducted within the framework of ART programs showing the relationship between telomere length, telomerase activity, and fertility. Many studies have shown that the length of telomeres in human germ cells has a positive effect on the formation and further development of embryos. The relationship between the length of telomere regions and fertility has also been demonstrated. For example, males with shorter telomeres have lower-quality embryos than those with longer sperm telomeres. Males with higher sperm DNA fragmentation are also observed to have a shorter telomere length. In women, the short telomere length is associated with different diseases. The presence of elongated telomeres in the oocytes has shown that the probability of forming good-quality embryos increases.Petrova O.V., Kirillova A.O., Nalobin D.S., Ushakova I.V., Abubakirov A.N.
Conclusion. The role of telomere length and telomerase activity in the germ cells can make it possible to predict the effectiveness of ART programs and to introduce new analyses aimed at finding the causes of male and female infertility in future.
Keywords
telomeres
telomerase
sperm telomere length
oocyte telomere length
ART
IVF
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Received 24.08.2020
Accepted 29.10.2020
About the Authors
Olga V. Petrova, junior researcher of 1st gynecology department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. Тel.: +7(917)533-32-08. Е-mail: olga.zaharkina.90@mail.ru. 117997, Russia, Mosсow, Ac. Oparina str., 4.Anastasia O. Kirillova, PhD, senior researcher of 1st gynecology department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. , Е-mail: stasia.kozyreva@gmail.com. 117997, Russia, Mosсow, Ac. Oparina str., 4.
Denis S. Nalobin, PhD, senior researcher of Laboratory of Prototyping and Testing of Biological Developments, Faculty of Biology; Associate Professor, Faculty of Biotechnology, M.V. Lomonosov Moscow State University. Tel: +7(495)939-33-35. E-mail: denis.nalobin@gmail.com. 119991, Russia, Mosсow, Leninskije gory, 1.
Irina V. Ushakova, PhD, embryologist of 1-st gynecology department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. Тel.: +7(495)438-26-22. Е-mail: irisun77@mail.ru. 117997, Russia, Mosсow, Ac. Oparina str., 4.
Aidar N. Abubakirov, PhD, Head of 1st gynecology department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. Тel.: +7(495)438-26-22. Е-mail: nondoc555@yahoo.com. 117997, Russia, Mosсow, Ac. Oparina str., 4.
For citation: Petrova O.V., Kirillova A.O., Nalobin D.S., Ushakova I.V., Abubakirov A.N. Impact of telomere length and telomerase activity on the outcomes of assisted reproductive technology programs.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 11: 49-54 (in Russian).
https://dx.doi.org/10.18565/aig.2020.11.49-54