Transdermal estrogens in assisted reproductive technology programs
The paper presents historical data on the use of estrogens in gynecology. The advantages of transdermal drug formulations are shown to be the constant rate of release and absorption of the active ingredient, which ensure the minimal variability of its concentrations in the systemic circulation, greater bioavailability, and no effect of the ingredient on the gastrointestinal tract and metabolic profile. The authors analyze the currently available data on the use of transdermal estrogens in assisted reproductive technology programs in the most common clinical scenarios: donor oocyte/embryo and cryopreserved embryo transfers in patients with ovarian anovulation or depletion and a thin endometrium.Korneeva I.E., Nazarenko T.A.
Keywords
transdermal estrogens
assisted reproductive technology
cryopreserved embryo transfer
oocyte/embryo donation
thin endometrium
References
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Received 08.06.2018
Accepted 22.06.2018
About the Authors
Korneeva, Irina E., PhD, Leading Researcher at Department of Preservation and Restoration of the Reproductive Function, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954382622. E-mail: i_korneeva@oparina4.ruNazarenko, Tatyana A., Doctor of Medical Sciences, Professor, Chief Researcher, Moscow Research Institute of Obstetrics and Gynecology.
101000, Russia, Moscow, Pokrovka str. 22a. Tel.: +74956222233. E-mail: t.nazarenko@mail.ru
For citations: Korneeva I.E., Nazarenko T.A. Transdermal estrogens in assisted reproductive technology programs. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (9): 34-40. (in Russian)
https://dx.doi.org/10.18565/aig.2018.9.34-40
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