The role of various factors affecting the endometrium in enhancing the effectiveness of assisted reproductive technology programs

Gokhberg Ya.A., Makarova N.P., Babayan A.A., Kalinina E.A.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Whether the effectiveness of assisted reproductive technology (ART) programs can be enhanced remains relevant, despite the actively continued investigations aimed at identifying the causes of failures and new methods for treatment. One of the main factors influencing the effectiveness of embryo implantation is the state of the endometrium; for its study, investigators used molecular genetic and immunohistochemical studies. Taking into account the changes detected in the endometrium, it is promising to use own platelet-rich plasma (PRP) in the endometrium preparing programs for embryo implantation. Analysis of the literature on the use of PRP in other medical fields indicates the efficiency of this treatment option in terms of both clinical symptoms and a number of laboratory and functional studies. The use of PRP in in vitro fertilization (IVF) programs in patients with failed implantation attempts will affect the structure and functional activity of the endometrium.

Keywords

assisted reproductive technologies
pregnancy
platelet-rich plasma (PRP)
platelet concentrate
endometrium
thin endometrium
chronic endometritis
Asherman syndrome
embryo implantation

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Received 13.05.2020

Accepted 14.10.2020

About the Authors

Yael A. Gokhberg, postgraduate student at the Department of Assistive Technologies in Infertility Treatment, V.I. Kulakov NMRC OG&P, Ministry of Health of the Russian Federation. E-mail: dr.yaelgokhberg@gmail.com. 4 Oparin str, 117997, Moscow, Russia.
Nataliya P. Makarova, M.D., Ph.D., Leading Research Associate, Department of Assistive Technologies in Infertility Treatment, V.I. Kulakov NMRC OG&P, Ministry of Health of the Russian Federation. E-mail: np_makarova@oparina4.ru.4 Oparin str, 117997, Moscow, Russia.
Alina A. Babayan, PhD., Senior Research Associate, Department of Assistive Technologies in Infertility Treatment, V.I. Kulakov NMRC OG&P, Ministry of Health of the Russian Federation. E-mail: a_babayan@oparina4.ru. 4 Oparin str, 117997, Moscow, Russia
Elena A. Kalinina, M.D., Ph.D., professor, Head of Department of Assistive Technologies in Infertility Treatment, V.I. Kulakov NMRC OG&P, Ministry of Health of the Russian Federation. E-mail: e_kalinina@oparina4.ru. 4 Oparin str, 117997, Moscow, Russia

For citation: Gokhberg Ya.A., Makarova N.P., Babayan A.A., Kalinina E.A. The role of various factors affecting the endometrium in enhancing the effectiveness of assisted reproductive technology programs.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 1: 28-34 (in Russian).
https://dx.doi.org/10.18565/aig.2021.1.28-34

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