Clinical and medical history characteristics of pregnant women with different cervical cytology results
Rosyuk E.A., Oboskalova T.A., Zornikov D.L., Ten A.R., Askerova M.G., Sevostyanova O.Yu., Soloviev D.V., Kudimov A.A., Bikbulatova E.R., Averchenkova E.A.
Objective: To determine the clinical and medical history characteristics of pregnant women with different cervical cytology results.
Materials and methods: This retrospective study included 349 patients aged 18–44 years (median=32,
Q25–Q75: 29–36). Group 1 included pregnant women without a history of cervical surgery and NILM cytology reports (n=136); group 2 included pregnant women with a history of cervical conization (before pregnancy) for obligate precancer and NILM cytology reports at the time of inclusion in the study (n=67); group 3 included pregnant patients with mild dysplasia (LSIL by cytology, n=63), and group 4 included pregnant patients with severe dysplasia (HSIL according to cytology, n=83). Statistical analysis and data visualization were performed using R version 4.4.0 (build 2024-04-24). The statistical significance of differences between categorical variables was assessed using two-tailed Fisher's exact test, and differences between continuous variables were assessed using the Kruskal-Wallis test. Differences were considered statistically significant at p<0.05.
Results: Pregnant women with HSIL cytology had a nicotine addiction rate of 44.6% (p<0.001), initiated sexual activity at ages 16–18 (p<0.001), a high abortion rate of 59% (p=0.005), and a high birth rate of 83.1% (p=0.016). They also had a high rate of gynecological diseases in general (65.1%, p=0.018) as well as sexually transmitted infections, HIV infections, and viral hepatitis C. Patients with NILM cytology had a higher rate of endometriosis (p=0.018) and ovarian lesions (p=0.037) than those with abnormal cytology. Women with a history of cervical conization were distinguished by the absence of allergic reactions compared to those in the other groups (p<0.001). There were no differences in the rates of extragenital diseases.
Conclusion: Distinct medical history characteristics were observed in patients, depending on the results of the cytological examination. All pregnant women exhibited low adherence to the use of contraceptive methods, a significant number of pregnancy terminations, and high parity.
Authors' contributions: Rosyuk E.A., Oboskalova T.A. – conception and design of the study; Zornikov D.L. – statistical analysis, editing of the manuscript; Soloviev D.V., Kudimov A.A., Bikbulatova E.R., Averchenkova E.A. – material collection; Rosyuk E.A., Ten A.R., Askerova M.G., Sevostyanova O.Yu. – drafting of the manuscript.
Conflicts of interest: The authors have no conflicts of interest to declare.
Funding: There was no funding for this study.
Ethical Approval: The study was reviewed and approved by the Research Ethics Committee of the Ural State Medical University, Ministry of Health of the Russian Federation.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.
For citation: Rosyuk E.A., Oboskalova T.A., Zornikov D.L., Ten A.R., Askerova M.G., Sevostyanova O.Yu., Soloviev D.V., Kudimov A.A., Bikbulatova E.R., Averchenkova E.A. Clinical and medical history characteristics of pregnant women with different cervical cytology results.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (1): 73-81 (in Russian)
https://dx.doi.org/10.18565/aig.2024.226
Keywords
pregnancy
NILM
LSIL
HSIL
risk factor
cytological examination
References
- Гарелик Т.М., Наумов И.А. Выявление медико-социальных факторов риска рака шейки матки и ухудшения репродуктивного здоровья. Современные проблемы гигиены, радиационной и экологической медицины. 2020; 10: 69-82. [Harelik T.M., Naumau I.A. Identification of medical-social risk factors of cervical cancer and deterioration of reproductive health. Modern Problems of Hygiene, Radiation and Environmental Medicine. 2020; (10): 69-82. (in Russian)].
- Росюк Е.А., Обоскалова Т.А., Емельянова Е.С., Буторина Н.В., Емельянова Т.Г., Глухов Е.Ю., Нефф Е.И., Якушев А.М. Влияние электроконизации шейки матки до зачатия на течение беременности и родов. Акушерство и гинекология. 2024; 6: 105-12. [Rosyuk E.A., Oboskalova T.A., Emelyanova E.S., Butorina N.V., Emelyanova T.G., Glukhov E.Yu., Neff E.I., Yakushev A.M. Effect of preconceptional cervical electroconizationon the course of pregnancy and childbirth. Obstetrics and Gynecology. 2024; (6): 105-12 (in Russian)]. https://dx.doi.org/10.18565/aig.2024.23.
- Larish A., Long M.E. Diagnosis and management of cervical squamous intraepithelial lesions in pregnancy and postpartum. Obstet. Gynecol. 2024; 144(3): 328-38. https://dx.doi.org/10.1097/AOG.0000000000005566.
- Министерство здравоохранения Российской Федерации. Клинические рекомендации. Цервикальная интраэпителиальная неоплазия, эрозия и эктропион шейки матки. 2020. 57с. [Ministry of Health of the Russian Federation. Clinical guidelines. Cervical intraepithelial neoplasia, erosion and ectropion of the cervix. 2020. 57p. (in Russian)].
- Росюк Е.А., Обоскалова Т.А., Верба Т.Е., Салимова И.В., Туреева А.В. Анализ структуры гинекологических заболеваний и объема оперативного вмешательства у пациенток кабинета патологии шейки матки и эндометрия в разных возрастных группах. Акушерство и гинекология. 2024; 5: 92-8. [Rosyuk E.A., Oboskalova T.A., Verba T.E., Salimova I.V., Tureeva A.V. Analysis of the structure of gynecological diseases and extent of surgery in patients of different age groups supervised in the cervical and endometrial pathology office. Obstetrics and Gynecology. 2024; (5): 92-8 (in Russian)]. https://dx.doi.org/10.18565/aig.2024.6.
- Orya E.E., Bello K.K., Sampson S., Envuladu E.A., Okagbue H.I. Varying behavioral differences and correlates of HPV infection among young adolescents in Benue state, Nigeria. BMC Public Health. 2024; 24(1): 1548. https://dx.doi.org/10.1186/s12889-024-19068-7.
- Chen L., Zhang Y., Liu L., Hayashi T., Cui N., Liu Y. Risk factors predicting pathological degradation after cervical excision in cervical intraepithelial neoplasia grade II P16-positive patients over 25 years old: a cross-sectional study. Transl. Cancer Res. 2023; 12(11): 3147-55. https://dx.doi.org/10.21037/tcr-23-1745.
- Зароченцева Н.В., Аршакян А.К., Титченко Ю.П., Меньшикова Н.С., Баринова И.В., Ушакова С.В. Применение препарата аллокина-альфа в комплексной терапии пациенток с хроническим эндометритом и привычным невынашиванием беременности. Российский вестник акушера-гинеколога. 2014; 14(4): 74‑80. [Zarochentseva N.V., Arshakian A.K., Titchenko Iu.P., Men'shikova N.S., Barinova I.V., Ushakova S.V. Use of allokine-alpha in the combination therapy of patients with chronic endometritis and recurrent miscarriage. Russian Bulletin of Obstetrician-Gynecologist. 2014; 14(4): 74-80. (in Russian)].
- Matalliotakis M., Matalliotaki C., Zervou M.I., Krithinakis K., Kalogiannidis I., Goulielmos G.N. Coexistence of cervical endometriosis with premalignant and malignant gynecological pathologies: report on a series of 27 cases. Women Health. 2021; 61(9): 896-901. https://dx.doi.org/10.1080/03630242.2021.1991073.
- O'Neill C.J., McCluggage W.G. p16 expression in the female genital tract and its value in diagnosis. Adv. Anat. Pathol. 2006;13(1): 8-15. https://dx.doi.org/10.1097/01.pap.0000201828.92719.f3.
- Kristensen M.L., Waldstrøm M., Laursen A.S.D., Eriksen K., Ulrichsen S.P., Hatch E.E. et al. Cervical intraepithelial neoplasia and fecundability: a prospective cohort study. Hum. Reprod. 2024; 39(8): 1835-43. https://dx.doi.org/10.1093/humrep/deae139.
- Бебнева Т.Н., Дикке Г.Б. Алгоритм диагностики заболеваний шейки матки и ведения беременных женщин, инфицированных ВПЧ. Акушерство и гинекология. 2020; 12(Приложение): 22-5. [Bebneva T.N., Dicke G.B. Algorithm for the diagnosis of cervical diseases and management of pregnant women infected with HPV. Obstetrics and Gynecology. 2020; 12(Suppl.):22-5. (in Russian)].
- Kozłowska R., Bożek A., Jarząb J. Association between cancer and allergies. Allergy Asthma Clin. Immunol. 2016; 12: 39. https://dx.doi.org/10.1186/s13223-016-0147-8.
- Joost van Neerven J. Mucosal immunity: barriers, bugs, and balance. Wageningen University; 2014. Available at: https://edepot.wur.nl/330156.
Received 09.09.2024
Accepted 23.12.2024
About the Authors
Elena A. Rosyuk, PhD, Associate Professor at the Department of Obstetrics and Gynecology, Ural State Medical University, Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 3, +7(902)26-56-385, elenakdc@yandex.ru, https://orcid.org/0000-0003-1303-3955Tatyana A. Oboskalova, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Ural State Medical University, Ministry of Health of Russia,
620028, Russia, Yekaterinburg, Repin str., 3, +7(912)28-37-631, oboskalova.tat@yandex.ru, https://orcid.org/ 0000-0003-0711-7896
Danila L. Zornikov, PhD, Associate Professor, Head of the Laboratory of Genetic and Epigenetic Foundations for Predicting Disorders of Ontogenesis and Human Aging, Associate Professor at the Department of Medical Microbiology and Clinical Laboratory Diagnostics, Ural State Medical University, Ministry of Health of Russia,
620028, Russia, Yekaterinburg, Klyuchevskaya str., 17, +7(900)20-65-926, zornikovdl@yandex.ru, https://orcid.org/0000-0001-9132-215X
Angelika R. Ten, PhD, Teaching Assistant at the Department of Obstetrics and Gynecology with a Course of Medical Genetics, Ural State Medical University,
Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 3, +7(912)20-30-241, tenar79@mail.ru, https://orcid.org 0000-0002-6349-9756
Marina G. Askerova, PhD, Associate Professor, Department of Obstetrics and Gynecology with a Course in Medical Genetics, Ural State Medical University,
Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 3, mg.askerova@gmail.com
Olga Yu. Sevostyanova, Dr. Med. Sci., Professor, Department of Obstetrics and Gynecology with a Course of Medical Genetics, Ural State Medical University,
Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 3, olsyava@gmail.com, https://orcid.org/0000-0002-0828-0479
Denis V. Soloviev, student, Ural State Medical University, Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 3, +7(996)22-94-265, den.sol2011@gmail.com
Andrey A. Kudimov, student, Ural State Medical University, Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 3, +7(982)61-25-200,
es.tine.dorian@gmail.com
Elina R. Bikbulatova, student, Ural State Medical University, Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 3, +7(922)16-65-155,
bzema9471@gmail.com
Elizaveta A. Averchenkova, student, Ural State Medical University, Ministry of Health of Russia, 620028, Russia, Yekaterinburg, Repin str., 3, +7(992)00-88-962,
aviga-02@yandex.com
Similar Articles
