Thin endometrium as one of the causes of IVF failures

DOI

https://dx.doi.org/10.18565/aig.2023.65

Aryutin D.G.
1) Medical Institute, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia; 2) N.E. Bauman City Clinical Hospital No. 29, Moscow City Healthcare Department, Moscow, Russia

Objective: To analyze current literature data on the etiology, diagnosis, and treatment of thin endometrium and to identify the relationship between endometrial thickness and pregnancy rate in the assisted reproductive technology (ART) program.
Materials and methods: The PubMed and Cochrain Library databases over the past few years were analyzed to make a review.
Results: The paper presents modern ideas on the etiology, diagnosis, and treatment of thin endometrium, as well as on the role of endometrial thickness in the onset of pregnancies in ART programs, as evidenced by Russian and foreign literature. Until now, many studies are contradictory and controversial, which cannot reach a consensus on the thin endometrium. This issue is still relevant and further multicenter studies will be able to approximate to the unraveling and solving of the problem.
Conclusion: The endometrial thickness is one of the main risk factors for implantation failure in IVF, so physicians of different specialties are studying this topical issue to have positive results. There is a need for further investigations in this area, including those of the morphological, immunohistochemical, and molecular genetic characteristics of the endometrium, which will be able to improve the outcomes of ART in the presence of thin endometrium.

Conflicts of interest: The author declares that there are no potential conflicts of interest to be revealed in this article.
Funding: The investigation has not been sponsored.
For citation: Aryutin D.G. Thin endometrium as one of the causes of IVF failures.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (3): 129-133 (in Russian)
https://dx.doi.org/10.18565/aig.2023.65

infertility

endometrial thickness

in vitro fertilization

thin endometrium

Full text (in Russian)

Оразов М.Р., Радзинский В.Е., Хамошина М.Б., Кайгородова Л.А., Токтар Л.Р., Покуль Л.В., Тулупова М.С. Тайны репродуктивных неудач: «тонкий» эндометрий. Репродуктивная медицина. 2018; 2: 7-17. [Orazov M.R., Radzinsky V.E., Khamoshina M.B., Kaygorodova L.A., Toktar L.R., Pokul L.V., Tulupova M.S. Secrets of reproductive failures: "thin" endometrium. Reproductive Medicine. 2018; (2): 7-17. (in Russian)].
Радзинский В.Е., Оразов М.Р., Михалева Л.М., Силантьева Е.С., Семенов П.А., Лагутина Е.В., Орехов Р.Е. Предикторы неудач ЭКО при имплантационной несостоятельности эндометрия. Трудный пациент. 2021; 19(1): 23-6. [Radzinsky V.E., Orazov M.R., Mihaleva L.M., Silantyeva E.S., Semenov P.A., Lagutina E.V., Orehov R.E. Predictors of IVF failures in implantation failure of the endometrium. Difficult Patient. 2021; 19(1): 23-6. (in Russian)].https://dx.doi.org/10.24412/2074-1995-2021-1-23-26.
Павлова М.В., Тапильская Н.И. Проблема тонкого эндометрия в циклах экстракорпорального оплодотворения. Вестник СурГУ. Медицина. 2020; 4: 63-7. [Pavlova M.V., Tapilskaya N.I. The problem of thin endometrium in the in vitro fertilization cycles. Bulletin of SurGU. Medicine. 2020; (4): 63-7. (in Russian)].
Lv H., Zhao G., Jiang P., Wang H., Wang Z., Yao S. et al. Deciphering the endometrial niche of human thin endometrium at single-cell resolution. Proc. Natl. Acad. Sci. USA. 2022; 119(8): e2115912119. https://dx.doi.org/10.1073/pnas.2115912119.
Попова М.В., Луцик В.В., Рыкова Д.В., Рыков А., Глушич С., Заец Е. Тонкий эндометрий как причина репродуктивных потерь и неудачных попыток ЭКО (обзор литературы). Медико-социальные проблемы семьи. 2020; 25(1): 86-9. [Popova M.V., Lutsik V.V., Rykova D.V., Rykov A., Glushich S., Zayets E. Thin endometrium as the cause of reproductive losses and failed IVF attempts (literature review). Medical and Social Problems of the Family. 2020; 25(1): 86-9. (in Russian)].
Mouhayar Y., Franasiak J.M., Sharara F.I. Obstetrical complications of thin endometrium in assisted reproductive technologies: a systematic review. J. Assist. Reprod. Genet. 2019; 36(4): 607-11. https://dx.doi.org/10.1007/s10815-019-01407-y.
Critchley H.O.D., Maybin J.A., Armstrong G.M., Williams A.R.W. Physiology of the endometrium and regulation of menstruation. Physiol. Rev. 2020; 100(3): 1149-79. https://dx.doi.org/10.1152/physrev.00031.2019.
Santamaria X., Isaacson K., Simón C. Asherman's syndrome: it may not be all our fault. Hum. Reprod. 2018; 33(8): 1374-80. https://dx.doi.org/10.1093/humrep/dey232.
Cha J., Sun X., Dey S.K. Mechanisms of implantation: strategies for successful pregnancy. Nat. Med. 2012; 18(12): 1754-67. https://dx.doi.org/10.1038/nm.3012.
Ranisavljevic N., Raad J., Anahory T., Grynberg M., Sonigo C. Embryo transfer strategy and therapeutic options in infertile patients with thin endometrium: a systematic review. J. Assist. Reprod. Genet. 2019; 36(11): 2217-31.https://dx.doi.org/10.1007/s10815-019-01576-w.
Hershko-Klement A., Tepper R. Ultrasound in assisted reproduction: a call to fill the endometrial gap. Fertil. Steril. 2016; 105(6): 1394-402.e4.https://dx.doi.org/10.1016/j.fertnstert.2016.04.012.
Cui N., Li A.M., Luo Z.Y., Zhao Z.M., Xu Y.M., Zhang J. et al. Effects of growth hormone on pregnancy rates of patients with «thin» endometrium. J. Endocrinol. Invest. 2019; 42(1): 27-35. https://dx.doi.org/10.1007/s40618-018-0877-1.
Shang Y., Wu M., He R., Ye Y., Sun X. Administration of growth hormone improves endometrial function in women undergoing in vitro fertilization: a systematic review and meta-analysis. Hum. Reprod. Update. 2022; 28(6):838-57. https://dx.doi.org/10.1093/humupd/dmac028.
Sood A., Mohiyiddeen G., Ahmad G., Fitzgerald C., Watson A., Mohiyiddeen L.Growth hormone for in vitro fertilisation (IVF). Cochrane Database Syst. Rev. 2021; 11(11): CD000099. https://dx.doi.org/10.1002/14651858.CD000099.pub4.
Храмцова А.Ю., Башмакова Н.В. Современный взгляд на проблему «тонкого» эндометрия: пути решения в программах ВРТ (обзор литературы). Проблемы репродукции. 2019; 25(4): 69-76. [Khramtsova A.Yu., Bashmakova N.V. Global view on the problem of «thin» endometrium: solutions to the problem in assisted reproductive technology (literature review). Russian Journal of Human Reproduction. 2019; 25(4): 69 76. (in Russian)].https://dx.doi.org/10.17116/repro20192504169.
Kamath M.S., Kirubakaran R., Sunkara S.K. Granulocyte-colony stimulating factor administration for subfertile women undergoing assisted reproduction. Cochrane Database Syst. Rev. 2020; 1(1): CD013226. https://dx.doi.org/10.1002/14651858.CD013226.pub2.
Di X., Gennings C., Bear H.D., Graham L.J., Sheth C.M., White K.L. Jr, Gewirtz D.A. Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells. Breast Cancer Res.Treat. 2010; 124(2): 349-60. https://dx.doi.org/10.1007/s10549-010-0765-7 27.
Pyriochou A., Zhou Z., Koika V., Petrou C., Cordopatis P., Sessa W.C., Papapetropoulos A. The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway. J. Cell. Physiol. 2007; 211(1): 197-204. https://dx.doi.org/10.1002/jcp.20929.
Li X., Luan T., Zhao C., Zhang M., Dong L., Su Y., Ling X. Effect of sildenafil citrate on treatment of infertility in women with a thin endometrium: a systematic review and meta-analysis. J. Int. Med. Res. 2020; 48(11): 300060520969584. https://dx.doi.org/10.1177/0300060520969584.
Hsieh Y.Y., Tsai H.D., Chang C.C., Lo H.Y., Chen C.L. Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: a prospective, randomized study. J. Assist. Reprod. Genet. 2000; 17(3): 174-7. https://dx.doi.org/10.1023/a:1009474307376.
Ke H., Jiang J., Xia M., Tang R., Qin Y., Chen Z.-J. The effect of tamoxifen on thin endometrium in patients undergoing frozen-thawed embryo transfer. Reprod. Sci. 2018; 25(6): 861-6. https://dx.doi.org/10.1177/1933719117698580.
Vartanyan E., Tsaturova K., Devyatova E. Thin endometrium problem in IVF programs. Gyneco.l Endocrinol. 2020; 36(Suppl. 1): 24-7. https://dx.doi.org/10.1080/09513590.2020.1816724.
Azizi R., Aghebati-Maleki L., Nouri M., Marofi F., Negargar S., Yousefi M. Stem cell therapy in Asherman syndrome and thin endometrium: Stem cell- based therapy. Biomed. Pharmacother. 2018; 102: 333-43. https://dx.doi.org/10.1016/j.biopha.2018.03.091.
Джинчарадзе Л.Г., Абубакиров А.Н., Мишиева Н.Г. Внутриматочное введение гранулоцитарного-колониестимулирующего фактора у пациенток с «тонким» эндометрием в программах криопереноса размороженных эмбрионов. Акушерство и гинекология. 2020; 8: 106-10. [Dzhincharadze L.G., Abubakirov A.N., Mishieva N.G. Intrauterine use of granulocyte colony-stimulating factor in patients with thin endometrium in frozen embryo transfer programs. Obstetrics and Gynecology. 2020; (8): 106-10. (in Russian)]. https://dx.doi.org/10.18565/aig.2020.8.106-110.
Цыганкова О.Ю., Кропмаер К.П., Кравченко Е.Н. Тонкий эндометрий. Пути решения проблемы. Российский вестник акушера-гинеколога. 2020; 20(2): 82-5. [Tsygankova O.Yu., Kropmaer K.P., Kravchenko E.N. Thin endometrium. Ways to solve the problem. Russian Bulletin of Obstetrician-Gynecologist. 2020; 20(2): 82 5. (in Russian)]. https://dx.doi.org/10.17116/rosakush20202002182.

Received 03.03.2023

Accepted 13.03.2023

Dmitry G. Aryutin, Ph.D., Head of the Gynecological Department, N.E. Bauman City Clinical Hospital No. 29, Moscow Healthcare Department; Associate Professor at the Department of Obstetrics and Gynecology with a course of perinatology, RUDN University, +7(903)772-95-38, aryutin@mail.ru, https://orcid.org/0000-0003-0258-8445, 111020, Russia, Moscow, Hospitalnaya Sqr., 2.

Thin endometrium as one of the causes of IVF failures

Aryutin D.G.

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