Overcoming resistance to pathogens of vulvovaginal candidiasis using modern methods

DOI

https://dx.doi.org/10.18565/aig.2022.2.102-108

Khashukoeva A.Z., Burdenko M.V., Markova E.A., Dmitrashko T.E.
1) Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia; 2) Russian Clinical and Research Center of Gerontology, Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Background: The therapy of vulvovaginal candidiasis (VVC) still remains an unsolved issue. The development of the pharmaceutical industry and clinical studies conducted with the use of various antimycotic drugs have not provided the clear answers to the questions about the treatment of VVC. Research work in this sphere is relevant. Among other antimycotic drugs in the pharmacological market, sertaconazole appears to be promising. It has high efficiency and safety indicators which are confirmed by a number of studies; the data of the studies are presented in the article. Sertaconazole is a drug that has a triple effect on fungal pathogens: fungicidal and fungistatic action, as well as inhibition of dimorphic transformation (it blocks the transition of the fungus from a non-pathogenic to a pathogenic one which significantly increases the inter-relapse interval of VVC.
Results: The therapeutic efficacy of sertaconazole was evaluated in 25 patients with chronic recurrent VVC. In all cases, the diagnosis of VVC was confirmed by clinical and laboratory methods, C. albicans was mainly identified in women. The patients received Zalain at a dose of 300 mg once in the form of a vaginal suppository. No patients reported side effects after taking the drug. A day after the introduction of the suppository, 13 patients noted a significant improvement in their condition due to a decrease in itching and burning and 12 patients noted the complete disappearance of symptoms of the disease. A week after the treatment, all patients’ symptoms of VVC were relieved; the results of the repeated cultural studies confirmed it.
Conclusion: The treatment of VVC with a drug containing sertaconazole determines a successful outcome in the fight against the disease. It is important to use an integrated approach in its treatment and include adjuvant therapy which significantly accelerates recovery. Such therapy can also be used for the prevention aimed at reducing the likelihood of recurrent VVC and/or concomitant diseases of the genital tract.

vulvovaginal candidiasis

recurrent vulvovaginal candidiasis

resistance to antifungal drugs

sertaconazole

Zalagel Intim

Zalain suppository

Zalain cream

Full text (in Russian)

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Received 01.02.2021

Accepted 14.12.2021

Asiyat Z. Khashukoeva, Dr. Med. Sci., Professor of the Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, +7(499)187-12-54, azk05@mail.ru, https://orcid.org/0000-0001-7591-6281, 129226, Russia, Moscow, 1st Leonova str., 16.
Marina V. Burdenko, PhD, Associate Professor, Department of Obstetrics and Gynecology, Deputy Dean of the Faculty of Additional Vocational Education, Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, +7(499)166-97-41, +7(926)280-63-67, bmv-0306@rambler.ru, https://orcid.org/0000-0002-0304-4901, 105187, Russia, Moscow, Fortunatovskaya str., 1.
Eleonora A. Markova, PhD, Assistant of the Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, +7(499)166-97-41, +7(926)280-63-67, markova.eleonora@mail.ru, https://orcid.org/0000-0002-9491-9303, 105187, Russia, Moscow, Fortunatovskaya str., 1.
Tatyana Ye. Dmitrashko, obstetrician-gynaecologist, Russian Gerontological Research and Clinical Center, Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, +7(499)187-12-54, lesnoy_elf@list.ru, https://orcid.org/0000-0002-0523-846X, 129226, Russia, Moscow, 1-st Leonova str., 16.

Authors’ contributions: Khashukoeva A.Z., Burdenko M.V. – developing the concept and design of the study;
Dmitrashko T.E. – collecting and processing the material; Dmitrashko T.E., Markova E.A. – statistical data processing; Khashukoeva A.Z., Markova E.A. – writing the text of the manuscript; Khashukoeva A.Z. – editing the text.
Conflicts of interest: The authors declare that they have no competing interests.
Funding: The study was performed without any financial support.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
For citation: Khashukoeva A.Z., Burdenko M.V., Markova E.A., Dmitrashko T.E. Overcoming resistance to pathogens of vulvovaginal candidiasis using modern methods.
Akusherstvo i Ginekologiya/ Obstetrics and Gynecology. 2022; 2: 102-108 (in Russian)
https://dx.doi.org/10.18565/aig.2022.2.102-108

Overcoming resistance to pathogens of vulvovaginal candidiasis using modern methods

Khashukoeva A.Z., Burdenko M.V., Markova E.A., Dmitrashko T.E.

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