Current ideas on vulvovaginal candidiasis
The article presents an explanation of the relevance of using regimens incorporating highly effective antimycotics in modern society, which is dictated by the lifestyle of large cities and the modern generation. After the symptoms of the disease disappear, many patients discontinue a prescribed drug treatment regimen on their own, interrupting the full cycle, which can lead to recurrences and unresponsiveness to treatment in the future.Kulikov I.A., Ovsyannikova T.V.
Keywords
vulvovaginal candidiasis
cream
clotrimazole
Candida albicans
thrush
candidiasis
short-term treatment
References
1. Малова И.О., Рахматулина М.Р., Соколовский Е.В. Федеральные клинические рекомендации по ведению больных урогенитальным кандидозом. М.: Российское общество дерматовенерологов и косметологов, Российское общество акушеров-гинекологов; 2016. [Malova I.O., Rakhmatulina M.R., Sokolovsky E.V. Federal clinical guidelines for the management of patients with urogenital candidiasis. Moscow: Russian Society of Dermatovenerologists and Cosmetologists, Russian Society of Obstetricians and Gynecologists; 2016 (in Russian)]
2. Moran P., Coleman D., Sulivan D. Candida albicans versus Candida dubliniensis: why is C. albicans more pathogenic? Int. J. Microbiol. 2012; 2012: 205921.
3. Papon N., Courdavault V., Clastre M., Bennett R.J. Emerging and emerged pathogenic Candida species beyond the Candida albicans paradigm. PLoS Pathog. 2013; 9(9): e1003550.
4. Butler G. Fungal sex and pathogenesis. Clin. Microb. Rev. 2010; 23(1): 140-59.
5. Butler G., Lorenz M., Gow N. Evolution and genomics of the pathogenic Candida species complex. In: Sibley L.D., Howlett B.J., Heitman J., eds. Evolution of virulence in eukaryotic microbes. Wiley-Blackwell; 2012: 404-21.
6. Федеральные клинические рекомендации по ведению больных урогенитальным кандидозом. Акушерство и гинекология. 2016; 4(Приложение): 50-6. [Federal clinical guidelines for management of patients with urogenital candidiasis. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2016; (4. Suppl.): 50-6. (in Russian)]
7. Серов В.Н., Буралкина Н.А., Борисенко М.Ю., Мамедова Ф.Ш. Клиническая эффективность флуконазола в лечении вульвовагинального кандидоза. Медицинский Совет. 2016; 2: 60-3. [Serov V.N., Buralkina N.A., Borisenko M.Yu., Mamedova F.Sh. The clinical efficacy of fluconazole in the treatment of vulvovaginal candidiasis. Meditsinskiy Sovet (Medical Council). 2016; 2: 60-3. (in Russian)] https://doi.org/10.21518/2079-701X-2016-2-60-63
8. Воронова О.А., Зильберберг Н.В., Кузнецова Ю.Н., Евстигнеева Н.П. Алгоритм выбора терапии больных урогенитальным кандидозом. Успехи современного естествознания. 2015; 2: 21-5. [Voronova O.A., Zilberberg N.V., Kuznetsova Yu.N., Evstigneeva N.P. Algorithm for the choice of treatment of patients with urogenital candidiasis. Successes of modern science. 2015; 2: 21-5. (in Russian)]
9. Jacobsen I.D., Wilson D., Wächtler B., Brunke S., Naglik J.R., Hube B. Candida albicans dimorphism as a therapeutic target. Expert Rev. Anti Infect. Ther. 2012; 10(1): 85-93.
10. Pfaller M.A. Antifungal drug resistance mechanisms, epidemiology and consequences for treatment. Am. J. Med. 2012; 125(1, Suppl.): S3-13.
11. Rezaei Z., Khabnadideh S., Pakshir K., Hossaini Z., Amiri F., Assadpour E. Design, synthesis and antifungal activity of triazole and benzotriazole derivatives. Eur. J. Med. Chem. 2009; 44(7): 3064-7.
12. Workowski K.A., Bolan G.A.; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm. Rep. 2015; 64(RR-03): 1-137.
13. Rotem R., Fishman B., Daniel S., Koren G., Lunenfeld E., Levy A. Risk of major congenital malformations following first-trimester exposure to vaginal azoles used for treating vulvovaginal candidiasis: a population-based retrospective cohort study. BJOG. 2018; 125(12): 1550-6.
Received 22.08.2018
Accepted 21.09.2018
About the Authors
Kulikov, Ilya A., PhD, MD, obstetrician-gynecologist, Department of Aesthetic Gynecology and Rehabilitation, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia; Associate Professor of the Department of Obstetrics, Gynecology, Perinatology and Reproductive Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University). 117997, Russia, Moscow, Ac. Oparina str. 4Ovsyannikova, Tamara V., MD, Professor of the Department of Obstetrics and Gynecology, Peoples’ Friendship University of Russia.
117198, Russia, Moscow, Miklukho-Maklaya str. 6. E-mail: dr.otoma@yandex.ru
For citations: Kulikov I.A., Ovsyannikova T.V. Current ideas on vulvovaginal candidiasis. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (10): 123-8. (in Russian)
https://dx.doi.org/10.18565/aig.2018.10.123-128
Similar Articles
