Treatment for vaginitis in pregnancy
Objective. To comparatively evaluate the clinical and laboratory effectiveness of different treatment regimens for vulvovaginal candidiasis (VVC) and bacterial vaginosis (BV) in pregnant women in the second and third trimesters.Katkova N.Yu., Guseva O.N., Kachalina O.V., Soshnikov A.V., Malyshev V.V., Zaslavskaya M.I., Sergeeva A.V.
Subjects and methods. Sixty-five patients with VVC and BV were examined and treated in the second and third trimesters of pregnancy. Group 1 consisted of 35 pregnant women with first diagnosed disease; Group 2 included 30 patients with recurrent disease. A short 3-day Gynomax treatment regimen or a long 7-day Gynomax one was used.
Results. Before treatment, there were increases in bacterial mass (11.2±1.7 Log) and in the number of aerobic and anaerobic microorganisms (6.2 (1.4) Log); as well as obvious Lactobacillus deficiency (3.1 (1.1) Log). Vaginal pH was more than 5.2 in 35/65 (53.8%) women.
After applying the seven-day Gainomax treatment regiment, complaints of vaginal discharge and itching persisted in 1/15 (6.6%) women; there were decreases in the total bacterial mass to 7.4 (1.2) Log and in aerobic and anaerobic flora to 2.4 (0.6) Log. Following the three-day use of the drug, pathological discharge and vulvar pruritus persisted in 2/15 (13.3%) of the pregnant women; the bacterial mass was much as 8.2 (1.7) Log; the concentration of aerobic and anaerobic flora was 3.9 (1.5) Log.
Conclusion. Both short- and long-course treatment regimens are equally effective during new-onset dysbiosis and VVC in pregnant women in the second and third trimesters. The seven-day regimen has an advantage in recurrent disease.
Keywords
bacterial vaginosis
vulvovaginal candidiasis
Gynomax
treatment
References
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Received 13.04.2020
Accepted 20.04.2020
About the Authors
Nadezhda Y. Katkova, MD; Head, Department of Obstetrics and Gynecology, Volga Research Medical University, Ministry of Health of Russia. Tel .: +7 (910) 381-38-51. E-mail: katkova_nu@inbox.ru 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, RussiaOlga I. Guseva, MD, Professor, Department of Obstetrics and Gynecology, Volga Research Medical University, Ministry of Health of Russia. Tel .: +7(910)791-42-83.
E-mail: alise52@yandex.ru 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia
Olga V. Kachalina, MD; Professor, Department of Obstetrics and Gynecology, Volga Research Medical University, Ministry of Health of Russia. Tel .: +7(951)904-34-06.
E-mail: yander24@bk.ru 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia
Artem V. Soshnikov, Cand. Med. Sci.; Associate Professor, Department of Obstetrics and Gynecology, Volga Research Medical University, Tel .: +7(920) 055-75-55.
E-mail: artvals@mail.ru 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia
Vyacheslav V. Malyshev, Cand. Med. Sci.; Associate Professor, Department of Obstetrics and Gynecology, Volga Research Medical University, Ministry of Health of Russia.
Tel .: +7(910) 798-33-56. E-mail: slavnyidoc@mail.ru 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia
Maya I. Zaslavskaya, BD, Professor, Department of Epidemiology, Microbiology, and Evidence-Based Medicine, Volga Research Medical University, Ministry of Health of Russia. E-mail: maya_zaslav@rambler.ru 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia
Anzhelika V. Sergeeva, Cand. Med. Sci.; Associate Professor, Professor, Department of Epidemiology, Microbiology, and Evidence-Based Medicine, Volga Research Medical University, Ministry of Health of Russia. Tel . +7(903) 060-39-84. Е-mail: sergeeva-av2013@yandex.ru 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603005, Russia
For reference: Katkova N.Yu., Guseva O.N., Kachalina O.V., Soshnikov A.V., Malyshev V.V., Zaslavskaya M.I., Sergeeva A.V. Treatment for vaginitis in pregnancy.
Akusherstvo i Ginekologiya. 2020; 4: 190-194. (In Russian).
https://dx.doi.org/10.18565/aig.2020.4.190-194
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