Effectiveness of prolonged use of fenticonazole in patients with chronic recurrent vulvovaginal candidiasis

Dobrokhotova Yu.E., Borovkova E.I., Burdenko M.V.

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Objective: To evaluate the effectiveness of a prolonged course of local therapy with fenticonazole for the prevention of recurrence of vulvovaginal candidiasis in patients with the chronic course of the disease. 
Materials and methods: This was a prospective observational study which included 206 patients with recurrent vulvovaginal candidiasis; the patients were divided into two groups. The main group included 96 patients who received the local treatment as follows: fenticonazole 600 mg twice with an interval of 72 hours, then 600 mg once every 10 days for 3 months (subgroup 1, n=36); fenticonazole 600 mg twice with an interval of 72 hours once a month for 3 months (subgroup 2, n=30); fenticonazole 600 mg once every 10 days + 2 courses of platelet-rich plasma therapy (subgroup 3, n=30). The control group included 110 women who received induction therapy with fluconazole 150 mg orally on days 1, 4, 7, and then 150 mg once a week for 3 months. The patients of the groups matched for age, body mass index, somatic and gynecological diseases.
Results: There were no significant differences in the recurrence rate of candida vaginitis in patients who received systemic and topical therapy (p=0.66), but the recurrence rate was significantly higher in the control group during three-month follow-up (p=0.043). The effectiveness of therapy was 94.55% in the control group and there was no recurrence of the disease in 76.36% of patients over the next 3 months. The effectiveness of therapy was 92.71% in the main group and recurrence was not observed in 87.5% of patients.
Conclusion: Topical fenticonazole is effective in relieving and preventing recurrence of vulvovaginal candidiasis. The administration of an induction and prolonged course of fenticonazole may be an acceptable alternative to systemic therapy.

Authors’ contributions: Dobrokhotova Yu.E. – developing the design of the study; Borovkova E.I., Burdenko M.V. – collecting the material, writing the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.
Authors’ Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Dobrokhotova Yu.E., Borovkova E.I., Burdenko M.V. Effectiveness of prolonged use of fenticonazole in patients with chronic recurrent vulvovaginal candidiasis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024 (1): 130-139 (in Russian)


vulvovaginal candidiasis
candida albicans
chronic recurrent vulvovaginal candidiasis
platelet-rich plasma


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Received 27.12.2023

Accepted 12.01.2024

About the Authors

Yulia E. Dobrokhotova, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Medicine, Pirogov Russian National Research Medical University, Ministry of Health of Russia, pr.dobrohotova@mail.ru, 117997, Russia, Moscow, Ostrovityanov str., 1, https://orcid.org/0000-0002-7830-2290
Ekaterina I. Borovkova, Dr. Med. Sci., Associate Professor, Professor, Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ministry of Health of Russia, +7(495)722-63-99, Katyanikitina@mail.ru, 117997, Russia, Moscow, Ostrovityanov str., 1, https://orcid.org/0000-0001-7140-262X
Marina V. Burdenko, PhD, Associate Professor, Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ministry of Health of Russia, +7(495)722-63-99, bmv-0306@rambler.ru, 117997, Russia, Moscow, Ostrovityanov str., 1, https://orcid.org/0000-0002-0304-4901

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