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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2021№2
Clinical use of drugs containing...

Clinical use of drugs containing sertaconazole in the treatment of vulvovaginal candidiasis

DOI
https://dx.doi.org/10.18565/aig.2021.2.158-166

Apolikhina I.A., Gorbunova E.A., Malyshkina D.A., Donnikov A.E.

1) Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia
Vulvovaginal candidiasis (VVC) is one of the problems of modern health care which reduces the quality of life of women. Candida albicans is a representative of the normal microflora of the vagina. Under certain conditions it affects the mucous membrane and forms an aggressive biofilm. Recurrent VVC is detected in 20–50% of patients. The search for effective, easy-to-use, affordable medical preparations is a major clinical challenge for a doctor. This article provides an overview of such a condition as VVC, aspects of its diagnosis, treatment, and prevention, as well as a clinical example and a description of drugs containing sertaconazole.
Conclusion. Complex therapy provides a comprehensive approach to the treatment of VVC in three stages: primary hygiene (Zalagel Intim gel), treatment (vaginal Zalain suppository, Zalain cream), intimate hygiene (Zalagel Intim gel). The advantages of applying vaginal Zalain suppositories are their single use, the absence of a systemic effect and a wide spectrum of action (it acts on both Candida albicans and Candida non-albicans), the absence of cross-resistance of fungi to the drug, absence of effects on the normal vaginal microflora (lactobacilli), concomitant antibacterial activity (on the coccal flora) and anti-inflammatory effect. A single intravaginal administration of a suppository at a dose of 300 mg is a complete course of treatment in exacerbation of VVC.

Keywords

vulvovaginal candidiasis
sertaconazole
Candida albicans
Сandida non-albicans
antifungals
mycoses
Full text (in Russian)

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Received 04.02.2021

Accepted 08.02.2021

About the Authors

Inna A. Apolikhina, MD, Head of the Department of Aesthetic Gynecology and Rehabilitation, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; Professor of the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education, I.M. Sechenov First MSMU, Ministry of Health of Russia (Sechenov University). E-mail: i_apolikhina@oparina4.ru.
117997, Russia, Moscow, Oparina str., 4.
Elena A. Gorbunova, obstetrician-gynecologist, physiotherapist of the Department of Aesthetic Gynecology and Rehabilitation, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: lifehelen@gmail.com.
117997, Russia, Moscow, Oparina str., 4.
Darya A. Malyshkina, graduate student, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. E-mail: nidsumi@mail.ru. 117997, Russia, Moscow, Oparina str., 4.
Andrey E. Donnikov, PhD, Head of the Laboratory of Molecular Genetic Methods, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. E-mail: donnikov@dna-technology.ru. 117997, Russia, Moscow, Oparina str., 4.

For citation: Apolikhina I.A., Gorbunova E.A., Malyshkina D.A., Donnikov A.E. Clinical use of drugs containing sertaconazole in the treatment of vulvovaginal candidiasis.
Akusherstvo i Ginekologiya / Obstetrics and gynecology. 2021; 2: 158-166 (in Russian)
https://dx.doi.org/10.18565/aig.2021.2.158-166

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