Low-grade intraepithelial cervical lesions in pregnant women with HPV and vaginal biocenotic disorders
The authors have established a relationship between intraepithelial cervical lesions and vaginal biocenotic disorders in pregnant women with human papillomavirus (HPV) infection and determined their management tactics. The HPV–positive pregnant women have a high incidence of vaginal dysbiosis (38.7%) that is, in most of them, characterized by co–infection (65%), mainly by anaerobic and aerobic infections (44.1%). High-rate HPV in the pregnant women is associated with bacterial vaginosis, mixed dysbiosis, and their recurrences and with the frequency of atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesions (LSIL) in the presence of an inflammatory response. Restoring the normal microflora contributes to the disappearance of the inflammatory response and to the reduction of ASCUS. Therapy for dysbiosis does not change the rate of LSIL at 3-month follow-up.Bebneva T.N., Dikke G.B.
Keywords
human papilloma virus
low-risk squamous intraepithelial cervical lesions
dysbiosis
bacterial vaginosis
aerobic vaginitis
vulvovaginal candidiasis
lactobacilli
clindamycin/butoconazole
References
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Received 07.09.2018
Accepted 21.09.2018
About the Authors
Bebneva, Tamara N., Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics, Gynecology and Reproductive Medicine, Faculty of Advanced Training for Medical Professionals of the Medical Institute of the Russian State University of People’s Friendship of the Ministry of Education and Science;the doctor of the NMISE of the Ministry of Health of Russia.
117198, Moscow, ul. Miklukho-Maklaya, 21, building. 3. Phone: +7 916 518 19 64. E–mail: bebn@mail.ru. ORCID.org 0000–0001–9524–8962.
Dikke, Galina B., doctor of medical sciences, associate professor, Professor of the Department of Obstetrics and Gynecology with a course of reproductive medicine,
Private Educational Institution «Academy of Medical Education named F.I. Inozemtsev», St. Petersburg.
190013, St. Petersburg, Moscow Ave, 22, letter M, tel.: 8 (812) 334–76–50. E–mail: galadikke@yandex.ru. ORCID.org 0000–0001–9524–8962.
For citations: Bebneva T.N., Dikke G.B. Low–grade intraepithelial cervical lesions in pregnant women with HPV and vaginal biocenotic disorders. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (11): 152-8. (in Russian)
https://dx.doi.org/10.18565/aig.2018.11.152-158
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