Role of transforming growth factor-β in the formation of fetal growth restriction
Objective. To study the diagnostic significance of transforming growth factor (TGF)-β1, TGF-β2, and TGF-β3 isoforms in fetal growth restriction (FGR).Khachatryan Z.V., Kan N.E., Vtorushina V.V., Krechetova L.V., Kharchenko D.K., Mantrova D.A., Tyutyunnik V.L.
Subjects and methods. Plasma samples from 48 women were examined during this investigation. The pregnant women were divided into 2 groups: 1) 28 pregnant women with FGR; 2) 20 women with physiological pregnancy. All the patients underwent multiplex measurement of the concentrations of TGF-β1, TGF-β2, and TGF-β3 isoforms by using the standard 3-plex Bio-Plex Pro assay system on a Bio-Plex 200 System flow-through laser immunoassay device (Bio-Rad, USA), followed by the processing of the results obtained in the Bio-Plex Manager Software version 6.0 Properties (Bio-Rad, USA).
Results. The level of TGF-β3 was ascertained to ne significantly lower in pregnant women with FGR (41.42 pg/ml)
than in apparently healthy pregnant women (48.42pg/ml) (p = 0.01). The levels of TGF-β1 and TGF-β2 did not statistically differ in the study groups.
Conclusion. The findings indicate that studying the plasma levels of TGF-β3 is promising in predicting fetal growth restriction.
Keywords
fetal growth restriction
transforming growth factor-β
placental insufficiency
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Received 20.05.2019
Accepted 21.06.2019
About the Authors
Zarine V Khachatryan., postgraduate student of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia. Tel.: +7(909)656-24-56. E-mail: z.v.khachatryan@gmail.com117997 Russia, Moscow, Ac. Oparina, 4 str.
Natalia E. Kan, PhD, MD, professor of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov
Ministry of Health of Russia. Tel.: +7(926)220-86-55. E-mail: kan-med@mail.ru. Number Researcher ID B-2370-2015. ORCID ID 0000-0001-5087-5946
117997 Russia, Moscow, Ac. Oparina, 4 str.
Valentina V. Vtorushina, PhD, doctor of the highest category of the Clinical Immunology of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia. Tel.:+7(916)980-78-95. E-mail: vtorushina@inbox.ru
117997 Russia, Moscow, Ac. Oparina, 4 str.
Lyubov V Krechetova., MD, Head of the Clinical Immunology Laboratory of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named
after Academician V.I. Kulakov Ministry of Health of Russia (117997, Moscow, Ac. Oparina, 4 str.). Tel.: +7(916)647-39-29. E-mail: l_krechetova@oparina4.ru .
ID Y-4837-208
117997 Russia, Moscow, Ac. Oparina, 4 str.
Daria K. Kharchenko, postgraduate student of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia. Tel.: +7(915)165-87-00. E-mail: drkharchenko@mail.ru
117997 Russia, Moscow, Ac. Oparina, 4 str.
Diana A Mantrova., postgraduate student of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia. Tel.: +7(909)636-72-59. E-mail: d-mantrova@yandex.ru
117997 Russia, Moscow, Ac. Oparina, 4 str.
Victor L. Tyutyunnik, PhD, MD, Head of the obstetric physiological department of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia. Tel.: +7(903)969-50-41. E-mail: tioutiounnik@mail.ru. ID B-2364-2015.ORCID ID 0000-0002-5830-5099
117997 Russia, Moscow, Ac. Oparina, 4 str.
For citation: Khachatryan Z.V., Kan N.E., Vtorushina V.V., Krechetova L.V., Kharchenko D.K., Mantrova D.A., Tyutyunnik V.L. Role of transforming growth factor-β in the formation of fetal growth restriction.
Akusherstvo i Ginekologiya / Obstetrics and Gynecology. 2019; (11): 107-12. (in Russian).
http://dx.doi.org/10.18565/aig.2019.11.107-112
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