The role of NOD1 and NOD2 receptors in recognizing pathogens in the female reproductive tract
NOD1 and NOD2 receptors belong to the NOD-like receptor (NLR) family. They are cellular cytosolic innate immune receptors that recognize the components of bacterial peptidoglycan and viral RNA. NOD1 and NOD2 are expressed in all organs of the female reproductive tract, with their maximum expression observed in the fallopian tubes. The endometrial expression of NOD1 mRNA does not depend on the phase of the menstrual cycle, while the expression of NOD2 is maximal in the late secretory phase. NOD1 and NOD2 are able to recognize a number of opportunistic and pathogenic bacteria, viruses, and protozoa. Some microorganisms (Listeria monocytogenes, Neisseria gonorrhoeae) have mechanisms to avoid recognition, which ensures their long-term intracellular persistence.Lebedeva O.P.
Keywords
innate immunity
NOD-like receptors
NOD1
NOD2
estradiol
progesterone
sexually transmitted infections
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Received 02.11.2018
Accepted 07.12.2018
About the Authors
Lebedeva, Olga P., MD, associate professor, professor of the Department of Obstetrics and Gynaecolgy of Belgorod State National Research University.308015, Russia, Belgorod, Pobedi str., 85; senior researcher of the Department of Genetics, Cytology and Bioengineering of Voronezh State University.
394018, Russia, Voronezh, Universitetskaya pl., 1. Tel.: +74722268591. E-mail: safonova2@yandex.ru ORCID 0000-0002-7188-6780
For citations: Lebedeva O.P. The role of NOD1 and NOD2 receptors in recognizing pathogens in the female reproductive tract. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (5): 25-9. (in Russian)
http://dx.doi.org/10.18565/aig.2019.5.25-29
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