Impact of systemic menopausal hormone therapy on symptoms of urinary incontinence in postmenopausal women
Urinary incontinence (UI) is one of the common symptoms in postmenopausal women. There is estrogen deficiency at the heart of the development of this disorder, as well as other signs of genitourinary syndrome of menopause (GSM), which makes menopausal hormone therapy (MHT) pathogenetically justified.Makovskaya D.S., Apolikhina I.A., Gorbunova E.A., Yureneva S.V.
The review includes the data of foreign and foreign publications found in the PubMed on this topic for the period from 2016 to 2022. The data available in the modern literature on the impact of systemic MHT on the symptoms of UI in postmenopausal women were systematically analyzed to improve approaches and to optimize patient management tactics.
Conclusion: Parodoxically, systemic MHT causes deterioration or development of UI, which may be associated with the effects of systemic estrogens on collagen metabolism in the perurethral tissues. Further study of the effect of estradiol-containing therapy on the genitourinary tract of postmenopausal women is relevant for the improvement of approaches and for the optimization of patient management tactics.
Authors’ contributions: Маkovskaya D.S. – the concept and design of the article, collection of publications, processing and analysis of the material on the topic, writing the text of the manuscript; Apolikhina I.A., Gorbunova E.A., Yureneva S.V. – editing.
Conflicts of interest: The authors declare that there are conflicts of interest.
Funding: The investigation has not been sponsored.
For citation: Makovskaya D.S., Apolikhina I.A., Gorbunova E.A., Yureneva S.V.
Impact of systemic menopausal hormone therapy on symptoms
of urinary incontinence in postmenopausal women.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (6): 44-50 (in Russian)
https://dx.doi.org/10.18565/aig.2023.41
Keywords
genitourinary syndromе of menopause
menopausal syndrome
urogenital disorders
vulvovaginal atrophy
urinary incontinence
postmenopause
menopausal hormone therapy
estradiol-containing therapy
systemic menopausal hormone therapy
estradiol
estrogens
menopause
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Received 10.02.2023
Accepted 30.05.2023
About the Authors
Diana S. Makovskaya, obstetrician-gynecologist, Junior Researcher at the Department of Aesthetic Gynecology and Rehabilitation, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, +7(905)717-54-91, md.makovskaya@gmail.com, https://orcid.org/0000-0003-0159-8641, 117997, Russia, Moscow, Ac. Oparina str., 4.Inna A. Apolikhina, Dr. Med. Sci., Professor, Head of the Department of Aesthetic Gynecology and Rehabilitation, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; Professor at the Department of Obstetrics, Gynecology, Perinatology, and Reproductology,
Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, +7(495)735-10-55, apolikhina@inbox.ru,
https://orcid.org/0000-0002-4581-6295, 117997, Russia, Moscow, Ac. Oparina str., 4.
Elena A. Gorbunova, obstetrician-gynecologist, Researcher at the Department of Aesthetic Gynecology and Rehabilitation, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, +7(495)531-44-44, el_gorbunova@oparina4.ru, https://orcid.org/0000-0002-4723-4299,
117997, Russia, Moscow, Ac. Oparina str., 4.
Svetlana V. Yureneva, Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of the Department of Vocational Education, Deputy Director of the Institute of Oncogynecology and Mammology, V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia,
+7(916)179-74-00, syureneva@gmail.com, https://orcid.org/0000-0003-2864-066X, 117997, Russia, Moscow, Ac. Oparina str., 4.
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