Initiation of labor activity as a multifactor mechanism of communication between maternal and fetal compartments

DOI

https://dx.doi.org/10.18565/aig.2022.2.20-26

Gaidarova A.R., Gusar V.A., Baev O.R.
1) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia; 2) I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

The timely spontaneous onset of labor is a coordinated process of interaction between the maternal and fetal organisms. The initiation of this process is contributed by various mechanisms, including the secretion of proinflammatory cytokines and chemokines with subsequent activation of the nuclear transcription factor NF-kB, the decreased progesterone receptor function, mechanical uterine distension that promotes the expression of monocyte chemotactic protein-1. The participation of the fetus itself that secretes signaling molecules (SP-A and PAF, corticotropin-releasing hormone, and endothelin-1) from the maturing organs and systems into the amniotic fluid is unquestionable in the induction of labor. The physiological aging of fetal membranes is also one of the triggering stimuli for normal labor, as a result of which there is sterile inflammation that triggers a cascade of events that promote the initiation of labor. The role of small noncoding RNA molecules, microRNAs (miR-200, miR-199a-3p, miR-214, miR-181, miR-143, miR-34b/c, and miR-338) in the control of myometrial relaxation and contractility during pregnancy and childbirth through the regulation of the expression of certain genes and the function of the progesterone receptor has been discussed recently.
Conclusion: Thus, a complex multifactorial process that is finely tuned and coordinated by a multitude of signaling molecules secreted by the maternal and fetal organisms leads to the increased contractility of the myometrium and to the initiation of labor activity.

labor induction

progesterone

fetal membrane aging

miRNA

exosomes

Full text (in Russian)

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Received 15.11.2021

Accepted 23.12.2021

Asiyat R. Gaidarova, PhD Student, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, +7(985)553-76-70, a_gadzhieva@oparina4.ru,
https://orcid.org/0000-0003-1415-3318, 117997, Russia, Moscow, Akademika Oparina str., 4.
Vladislava A. Gusar, PhD, Senior Researcher at the Laboratory of Applied Transcriptomics, Department of Systems Biology in Reproduction, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, +7(916)283-72-10, v_gusar@oparina4.ru, https://orcid.org/0000-0003-3990-6224, 117997, Russia, Moscow, Akademika Oparina str., 4.
Oleg R. Baev, Dr. Med. Sci., Professor, Head of the 1st Maternity Ward, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, o_baev@oparina4.ru, 117997, Russia, Moscow, Akademika Oparina str., 4; Professor of the Department of Obstetrics, Gynecology, Perinatology and Reproductology, I.M. Sechenov First MSMU, Ministry of Health of Russia, 119991, Russia, Moscow, Trubetskaya str., 8-2, https://orcid.org/0000-0001-8572-1971
Corresponding author: Asiyat R. Gaidarova, a_gadzhieva@oparina4.ru

Authors' contributions: Gaidarova A.R., Gusar V.A., Baev O.R. – information collection, text writing and editing.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
For citation: Gaidarova A.R., Gusar V.A., Baev O.R. Initiation of labor activity as a multifactor mechanism of communication between maternal and fetal compartments.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 2: 20-26 (in Russian)
https://dx.doi.org/10.18565/aig.2022.2.20-26

Initiation of labor activity as a multifactor mechanism of communication between maternal and fetal compartments

Gaidarova A.R., Gusar V.A., Baev O.R.

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