Features of endometrial tissue metabolism of androgens: a modern view

Gavisova A.A., Shevtsova M.A., Tskhovrebova L.T.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
The endometrium, the function of which depends on sex steroids synthesized in the ovaries, is one of the self-renewal systems with high regeneration in the human body. Numerous studies are devoted to the local study of the intracrinology of sex hormones in endometrial tissue. The activation and inactivation of sex steroids by the expression of hormones and enzymes play a key role in the functional activity of the endometrium, which is a guarantee of its competence for implantation and regeneration. The increased expression of aromatases is known to be necessary to create the optimal conditions for implantation, gestation, and prolonged pregnancy.
Measurement of endometrial tissue concentrations of steroids using liquid chromatography and tissue mass spectrometry could answer only a few questions about the role of synthesis of sex steroids, including endometrial androgens that act as active ligands for their receptors and as substrates for the biosynthesis of estrogens. A vivid model of the impaired expression of aromatase, the key enzyme for steroidogenesis, can be observed in the pathogenesis of endometriosis and endometrial cancer, which has led to the design of targeted drugs.
Conclusion: The active design of targeted drugs of selective androgen and estrogen receptor modulators arouses interest in their clinical efficacy in various endometrial diseases. Realizing the role of the effects of sex steroids on different organs and tissues in the female body, including cognitive, sexual functions and the realization of reproductive potential, it is necessary to individualize therapy, taking into account the peculiarities of their intracellular influence and the possibility of using them in each clinical case.




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Received 14.05.2021

Accepted 24.06.2021

About the Authors

Alla A. Gavisova, Ph.D., Senior Researcher of the 1st Gynecology Department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, gavialla@yandex.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Marina A. Shevtsova, medical resident, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare
of Russian Federation, +7(911)039-13-20, marina_981995@mail.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.
Linda T. Tskhovrebova, medical resident, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare
of Russian Federation, +7(989)748-48-88, linda.tskhovrebova@mail.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.

Authors’ contributions: Gavisova A.A., Shevtsova M.A., Tskhovrebova L.T. – review on the topic of the publication; writing the article; final approval of the version for publication.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has not been sponsored.

For citation: Gavisova A.A., Shevtsova M.A., Tskhovrebova L.T. Features of endometrial tissue metabolism of androgens: a modern view.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 9: 21-27 (in Russian)

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