Effectiveness of combined priming in a late reproductive age patient with androgen deficiency in the assisted reproductive technology program
Background: Late reproductive age is accompanied by a diminished ovarian reserve and a poor ovarian response as a result of physiological maturation and ovarian failure, and is a difficult problem in achieving pregnancy with one's own genetic material. Folliculogenesis of the active reproductive period is associated with sufficient androgen concentrations, which has been repeatedly shown in a model of women with polycystic ovary syndrome. The choice of the optimal method of treating infertility in late reproductive age women with androgen deficiency in the assisted reproductive technology program is currently the most discussed issue.Gavisova A.A., Shevtsova M.A., Burduli A.G.
Case report: The paper describes a clinical case of using combined androgen priming and metabolic therapy to improve folliculogenesis and embryogenesis in the in vitro fertilization program - intracytoplasmic sperm injection in a late reproductive age patient with androgen deficiency.
Conclusion: The combined approach to treating infertility in women of late reproductive age demonstrates a better clinical effect than to using androgen priming only.
Keywords
androgen deficiency
androgen therapy
infertility
folliculogenesis
embryogenesis
dehydroepiandrosterone
dehydroepiandrosterone sulfate
metabolic therapy
L-tyrosine
inositol
References
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Received 26.03.2022
Accepted 23.06.2022
About the Authors
Alla A. Gavisova, Ph.D., Leading Researcher at the 1st Gynecology Department, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, gavialla@yandex.ru, 117997, Russia, Moscow, Ac. Oparina str., 4.Marina A. Shevtsova, post-graduate student, Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, +7(911)039-13-20, marina_981995@mail.ru,
117997, Russia, Moscow, Ac. Oparina str., 4.
Anna G. Burduli, Ph.D., Senior Researcher at the Department of Assisted Reproductive Technologies in the Treatment of Infertility named after B.V. Leonov,
Academician V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia, burdulianna@gmail.com, 117997, Russia, Moscow, Ac. Oparina str., 4.
Authors' contributions: Gavisova A.A., Shevtsova M.A. – female follow-up and management, review on the topic of the publication, writing and executing the article, final approval of the version for publication; Burduli A.G. – review on the topic of the publication, writing and executing the article, final approval of the version for publication.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has not been sponsored.
Patient Consent for Publication: The patient provided informed consent for the publication of her data.
For citation: Gavisova A.A., Shevtsova M.A., Burduli A.G. Effectiveness of combined priming in a late reproductive age patient with androgen deficiency in the assisted reproductive technology program.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 7: 137-141 (in Russian)
https://dx.doi.org/10.18565/aig.2022.7.137-141
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