The role of paraoxonases in the pathogenesis of inflammatory and infectious diseases and cancer
The paraoxonase (PON) gene family contains three members: PON1, PON2, and PON3. All the three members of the family possess antioxidant properties and lipo-lactonase activity, and play a role in the pathogenesis of many inflammatory diseases, including atherosclerosis, Alzheimer’s and Parkinson’s diseases, diabetes mellitus, and cancer. Recent studies have demonstrated that the intracellular paraoxonases PON2 and PON3 associated with mitochondria and mitochondria-associated endoplasmic reticulum membranes regulate mitochondrial superoxide production and prevent apoptosis. As oxidative stress is a result of mitochondrial dysfunction and is involved in the development of inflammatory diseases, including atherosclerosis and cancer, the studies of the enzymes PON2 and PON3 can initiate many epidemiological surveys conducted to search for a relationship between the paraoxonase genes and the development of many inflammatory diseases. Understanding these mechanisms will be able to introduce new treatments for oxidative stress-related diseases.Levakov S.A., Sheshukova N.A., Obukhova E.A., Antipova N.V., Shakhparonov M.I.
Keywords
antioxidants
atherosclerosis
cancer
endoplasmic reticulum stress
inflammation
paraoxonase 1
paraoxonase 2
paraoxonase 3
bacterial quorum sensing
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Received 19.11.2019
Accepted 29.11.2019
About the Authors
Sergey A. Levakov, MD, PhD, professor, head of the Department of Obstetrics and Gynecology, FSAEI HE I.M.Sechenov First MSMU MOH, Russia.Address: Trubetskaya street 8/2, Moscow, 119991, Russian Federation.
Natalya A. Sheshukova, MD, PhD, professor of the Department of Obstetrics and Gynecology, FSAEI HE I.M.Sechenov First MSMU MOH, Russia.
Address: Trubetskaya street 8/2, Moscow, 119991, Russian Federation.
Elizaveta A. Obukhova, graduate student of the Department of Obstetrics and Gynecology, FSAEI HE I.M.Sechenov First MSMU MOH, Russia.
Address: Trubetskaya street 8/2, Moscow, 119991, Russian Federation. E-mail: liza_obukhova@mail.ru
Nadezhda V. Antipova, Candidate of Biological Sciences, researcher of the Shemyakin-Ovchinnikov Institute of bioorganic chemistry of the Russian Academy of Sciences, associate professor of the Department of Pharmaceutical and Toxicological Chemistry of the Peoples’ Friendship University of Russia.
Address: 117997, Moscow, GSP-7, ul. Miklukho-Maklaya, d. 16/10
Mikhail I. Shakhparonov, Doctor of Chemical Sciences, Leading Researcher of the Shemyakin-Ovchinnikov Institute of bioorganic chemistry of the Russian Academy
of Sciences.
Address: 117997, Moscow, GSP-7, ul. Miklukho-Maklaya, d. 16/10.
For citation: Levakov S.A., Sheshukova N.A., Obukhova E.A., Antipova N.V., Shakhparonov M.I.: The role of paraoxonases in the pathogenesis of inflammatory and infectious diseases and cancer.
Akusherstvo i Ginekologiya/Obstetrics and gynecology. 2020; 3: 26-32. (In Russian).
https://dx.doi.org/10.18565/aig.2020.3.26-32
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