Role of neutrophilic granulocytes in the development of endometriosis

Astashkin E.I., Vanko L.V., Krechetova L.V.

1) Department of General Pathology and Pathophysiology, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia; 2) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Contemporary literature data have been analyzed to consider the role of neutrophilic granulocytes in the development of inflammation as one of the leading pathogenetic mechanisms of endometriosis development. It has been shown that the idea of ​​neutrophilic granulocytes in the innate immunity system that plays one of the central roles in protecting the body from adverse effects has now expanded. The neutrophils exhibit a diverse spectrum of effector (generation of oxidative radicals, release of granules and formation of neutrophilic extracellular networks) and regulatory (production of cytokines, chemokines, angiogenic and fibrogenic factors) functions, which is due to the existence of a great number of neutrophil phenotypes that have different receptors that determine their functional capabilities. When interacting with other cells of the innate and adaptive immunity systems, the neutrophils are actively involved in the development of inflammation. Taken together, these data highlight the new role of neutrophils, which is associated with the pathogenesis of endometriosis in early events, such as angiogenesis and modulation of the local inflammatory environment.
Conclusion. The potentiated response to formyl peptide due to spontaneous neutrophil stimulation in pregnant women with preeclampsia suggests that their peripheral blood contain primed cells. This total response may suggest that the mechanism of stimulation of neutrophils due to their adhesion on the cell wall and to fMLP stimulation is different, additive in nature, and is carried out by different processes


neutrophilic granulocytes
effector and immunoregulatory functions


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Received 03.04.2020

Accepted 06.04.2020

About the Authors

Evgeny I. Astashkin, PhD, MD(Medicine) Professor, Department of General Pathology and Pathophysiology Federal State Budgetary Educational Institution Russian Medical Academy of Continuous Professional Education of Ministry of Healthcare of Russian Federation. Tel.: +7(495)680-05-99. E-mail:
2/1 Barrikadnaya str., Moscow, 125993, Russian Federation.
Lubov V. Krechetova, PhD, MD(Medicine), Head of the laboratory of clinical immunology National Medical Research Center for Obstetrics, Gynecology and Perinatology of Ministry of Healthcare of Russian Federation. Tel.: +7(495)438-11-83. E-mail:
4 Oparina str., Moscow, 117997, Russian Federation.
Lyudmila V. Vanko, PhD, MD(Medicine) Professor, leading researcher of the Laboratory of clinical immunology National Medical Research Center for Obstetrics, Gynecology and Perinatology of Ministry of Healthcare of Russian Federation. Tel.: +7(495)438-11-83. E-mail:
4 Oparina str., Moscow, 117997, Russian Federation

For reference: Astashkin E.I., Vanko L.V., Krechetova L.V. Role of neutrophilic granulocytes in the development of endometriosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 6: 5-12 (in Russian).

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