The role of vasoactive intestinal polypeptide in the development of gestational complications in women with repeat cesarean sections

1. Лисицына О.И., Шмаков Р.Г. «Ниши» рубца на матке после кесарева сечения: диагностика, лечение и исходы. Акушерство и гинекология. 2019; 9: 24-31. [Lisitsyna O.I., Shmakov R.G. Niches of the uterine scar after cesarean section: diagnosis, treatment, and outcomes. Obstetrics and Gynecology. 2019; (9): 24-31. (in Russian)]. https://dx.doi.org/10.18565/aig.2019.9.24-31.
2. Камилова М.Я., Юнусова С.Х., Узакова У.Д. Плацентарная недостаточность у беременных женщин с рубцом на матке. Sciences of Europe. 2017; 16(16): 27-9. [Kamilova M.Ya., Yunusova S.Kh., Uzakova U.D. The placental insufficientcy in pregnant woman with uteri scar. Sciences of Europe. 2017; 16(16): 27-9. (in Russian)].
3. Гаспарян С.А., Орфанова И.А., Ахмедова С.М., Василенко И.А. Новые аспекты патогенеза плацентарной недостаточности. Медицинский алфавит. 2023; 19: 44-8. [Gasparyan S.A., Orfanova I.A., Akhmedova S.M., Vasilenko I.A. New aspects of the pathogenesis of placental insufficiency. Medical Alphabet. 2023; (19): 44-8. (in Russian)]. https://dx.doi.org/10.33667/2078-5631-2023-19-44-48.
4. Савельева Г.М., Сухих Г.Т., Серов В.Н., Радзинский В.Е. Акушерство. Национальное руководство. 2-е изд. М.: ГЭОТАР-Медиа; 2019. 1080с. [Savelyeva G.M., Sukhikh G.T., Serov V.N., Radzinsky V.E. Obstetrics. National guide. 2nd ed. Moscow: GEOTAR-Media; 2019. 1080p. (in Russian)].
5. Полянин Д.В., Михельсон А.А., Мелкозерова О.А., Лукьянова К.Д. Дискуссионные вопросы несостоятельности рубца на матке в эру эпидемии кесарева сечения. Уральский медицинский журнал. 2019; 5: 17-23. [Polyanin D.V., Mikhel’son А.А., Melkozerova О.А., Luk’yanova K.D.Discussion issues of incompetent uterine scar in the era of the caesarian section epidemic. Ural Medical Journal. 2019; (5): 17-23. (in Russian)].https://dx.doi.org/10.25694/URMJ.2019.05.30.
6. Ramhorst R., Grasso E., Vota D., Gori S., Hauk V., Paparini D. et al. From decidualization to pregnancy progression: an overview of immune and metabolic effects of VIP. Am. J. Reprod. Immunol. 2022; 88(4): e13601.https://dx.doi.org/10.1111/aji.13601.
7. Grasso E., Gori S., Paparini D., Soczewski E., Fernández L., Gallino L. et al. VIP induces the decidualization program and conditions the immunoregulation of the implantation process. Mol. Cell. Endocrinol. 2018; 460: 63-72. https://dx.doi.org/10.1016/j.mce.2017.07.006.
8. Di Tommaso S., Cavallotti C., Malvasi A., Vergara D., Rizzello A., De Nuccio F. et al. A qualitative and quantitative study of the innervation of the human non pregnant uterus. Curr. Protein Pept. Sci. 2017; 18(2): 140-8. https://dx.doi.org/10.2174/1389203717666160330105341.
9. Kelm Junior A.R., Lancellotti C.L., Donadio N., Auge A.P., Lima S.M., Aoki T. et al. Nerve fibers in uterosacral ligaments of women with deep infiltrating endometriosis. J. Reprod. Immunol. 2008; 79(1): 93-9.https://dx.doi.org10.1016/j.jri.2008.08.004.
10. Pinsard M., Mouchet N., Dion L., Bessede T., Bertrand M., Darai E. et al. Anatomic and functional mapping of human uterine innervation. Fertil. Steril. 2022; 117(6): 1279-88. https://dx.doi.org/10.1016/j.fertnstert.2022.02.013.
11. Tokushige N., Markham R., Russell P., Fraser I.S. Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis. Fertil. Steril. 2007; 88(4): 795-803. https://dx.doi.org/10.1016/j.fertnstert.2006.12.078.
12. Bryman I., Norström A., Lindblom B., Dahlström A. Histochemical localization of vasoactive intestinal polypeptide and its influence on contractile activity in the non-pregnant and pregnant human cervix. Gynecol. Obstet. Invest. 1989; 28(2): 57-61. https://dx.doi.org/10.1159/000293515.
13. Ottesen B., Gerstenberg T., Ulrichsen H., Manthorpe T., Fahrenkrug J., Wagner G. Vasoactive intestinal polypeptide (VIP) increases vaginal blood flow and inhibits uterine smooth muscle activity in women. Eur. J. Clin. Invest. 1983; 13(4):321-4. https://dx.doi.org/10.1111/j.1365-2362.1983.tb00107.x.
14. Hansen V., Maigaard S., Allen J., Forman A. Effects of vasoactive intestinal polypeptide and substance P on human intramyometrial arteries and stem villous arteries in term pregnancy. Placenta. 1988; 9(5): 501-6.https://dx.doi.org/10.1016/0143-4004(88)90022-7.
15. Ottesen B., Ulrichsen H., Fahrenkrug J., Larsen J.J., Wagner G., Schierup L. et al. Vasoactive intestinal polypeptide and the female genital tract: relationship to reproductive phase and delivery. Am. J. Obstet. Gynecol. 1982; 143(4): 414-20. https://dx.doi.org/10.1016/0002-9378(82)90083-7.
16. Malvasi A., Tinelli A., Cavallotti C., Bettocchi S., Di Renzo G.C., Stark M. Substance P (SP) and vasoactive intestinal polypeptide (VIP) in the lower uterine segment in first and repeated cesarean sections. Peptides. 2010; 31(11): 2052-9. https://dx.doi.org/10.1016/j.peptides.2010.07.025.
17. Holst N., Oian P., Aune B., Jenssen T.G., Burhol P.G. Increased plasma levels of vasoactive intestinal polypeptide in pre-eclampsia. Br. J. Obstet. Gynaecol. 1991; 98(8): 803-6. https://dx.doi.org/10.1111/j.1471-0528.1991.tb13486.x.
18. Bourlev V., Moberg C., Ilyasova N., Davey E., Kunovac Kallak T.,Olovsson M. Vasoactive intestinal peptide is upregulated in women with endometriosis and chronic pelvic pain. Am. J. Reprod. Immunol. 2018; 80(3): e12857. https://dx.doi.org/10.1111/aji.12857.
19. Di Spiezio Sardo A., Florio P., Fernandez L.M., Guerra G., Spinelli M.,Di Carlo C. et al. The potential role of endometrial nerve fibers in the pathogenesis of pain during endometrial biopsy at office hysteroscopy. Reprod. Sci. 2015; 22(1): 124-31. https://dx.doi.org/10.1177/1933719114534536.
20. Van der Woude P.F., Goudsmit E., Wierda M., Purba J.S., Hofman M.A., Bogte H. et al. No vasopressin cell loss in the human hypothalamus in aging and Alzheimer's disease. Neurobiol. Aging. 1995; 16(1): 11-8.https://dx.doi.org/10.1016/0197-4580(95)80003-a.
21. Hogenboom R., Kalsbeek M.J., Korpel N.L., de Goede P., Koenen M., Buijs R.M. et al. Loss of arginine vasopressin- and vasoactive intestinal polypeptide-containing neurons and glial cells in the suprachiasmatic nucleus of individuals with type 2 diabetes. Diabetologia. 2019; 62(11): 2088-93.https://dx.doi.org/10.1007/s00125-019-4953-7.
22. Ishunina T.A., Swaab D.F. Estrogen receptor α splice variant TADDI in the human supraoptic nucleus: an effect on neuronal size and changes in pneumonia. Neuro Endocrinol. Lett. 2021; 42(2): 128-32.
23. Ishunina T.A., Bogolepova I.N., Swaab D.F. Increased neuronal nuclear and perikaryal size in the medial mamillary nucleus of vascular dementia and Alzheimer's disease patients: relation to nuclear estrogen receptor α. Dement. Geriatr. Cogn. Disord. 2019; 47(4-6): 274-80.https://dx.doi.org/10.1159/000500244.
24. Михальченко Д.В., Македонова Ю.А., Афанасьева О.Ю. Иммунологический анализ крови как диагностический фактор психоэмоционального стресса на стоматологическом приеме. Вестник Волгоградского государственного медицинского университета. 2020; 3: 70-4. [Mikhalchenko D.V., Makedonova Yu.A., Afanasyeva O.Yu. Immunological blood analysis as a diagnostic factor of psychoemotional stress at a dental appointment. Bulletin of Volgograd State Medical University. 2020; (3): 70-4. (in Russian)].https://dx.doi.org/10.19163/1994-9480-2020-3(75)-70-74.
25. Ляпин В.М., Туманова У.Н., Щеголев А.И. Синцитиальные узелки в ворсинах плаценты при преэклампсии. Современные проблемы науки и образования. 2015; 4: 499. [Lyapin V.M., Tumanova U.N., Shchegolev A.I. Syncytial knots of placental villi at preeclampsia. Modern Problems of Science and Education. 2015; (4): 499. (in Russian). https://dx.doi.org/10.17513/spno.21421.
26. Ревина Д.Б., Балацкий А.В., Ларина Е.Б., Мамедов Н.Н., Самоходская Л.М., Панина О.Б. Плацента-ассоциированные осложнения беременности:влияние полиморфизма rs4065 гена урокиназы. Вопросы гинекологии, акушерства и перинатологии. 2021; 20(1): 5-10. [Revina D.B.,Balatskiy A.V., Larina E.B., Mamedov N.N., Samokhodskaya L.M.,Panina O.B. Placental-related disorders of pregnancy: the influence of RS4065 polymorphism of the urokinase gene. Gynecology, Obstetrics andPerinatology. 2021; 20(1): 5-10. (in Russian)]. https://dx.doi.org/10.20953/1726-1678-2021-1-5-10.
27. Roca V., Calafat M., Larocca L., Ramhorst R., Farina M., Franchi A.M. et al. Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice. Reproduction. 2009; 138(4): 733-42.https://dx.doi.org/10.1530/REP-09-0171.
28. Ramhorst R., Calo G., Paparini D., Vota D., Hauk V., Gallino L. et al. Control of the inflammatory response during pregnancy: potential role of VIP as a regulatory peptide. Ann. N. Y. Acad. Sci. 2019; 1437(1): 15-21. https://dx.doi.org/10.1111/nyas.13632.
29. Gallino L., Hauk V., Fernández L., Soczewski E., Gori S., Grasso E. et al. VIP promotes recruitment of tregs to the uterine–placental interface during the peri-implantation period to sustain a tolerogenic microenvironment. Front. Immunol. 2020; 10: 2907. https://dx.doi.org/10.3389/fimmu.2019.02907.
30. Paparini D.E., Choudhury R.H., Vota D.M., Karolczak-Bayatti M., Finn-Sell S., Grasso E.N. et al. Vasoactive intestinal peptide shapes first-trimester placenta trophoblast, vascular, and immune cell cooperation. Br. J. Pharmacol. 2019; 176(7): 964-80. https://dx.doi.org/10.1111/bph.14609.
31. Paparini D.E., Grasso E., Fernandez L.D.C., Merech F., Weingrill-Barbano R., Correa-Silva S. et al. Decidual factors and vasoactive intestinal peptide guide monocytes to higher migration, efferocytosis and wound healing in term human pregnancy. Acta Physiol. (Oxf.). 2021; 232(1): e13579.https://dx.doi.org/10.1111/apha.13579.
32. Fraccaroli L., Grasso E., Hauk V., Cortelezzi M., Calo G., Pérez Leirós C. et al. Defects in the vasoactive intestinal peptide (VIP)/VPAC system during early stages of the placental-maternal leucocyte interaction impair the maternal tolerogenic response. Clin. Exp. Immunol. 2012; 170(3): 310-20.https://dx.doi.org/10.1111/j.1365-2249.2012.04668.x.

Received 09.08.2024

Accepted 28.11.2024