Periodontal diseases and their association with unwanted pregnancy outcomes

DOI

https://dx.doi.org/10.18565/aig.2022.4.26-33

Burduli A.G., Balmasova I.P., Tsarev V.N., Arutyunov S.D.
1) Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia; 2) A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the Russian Federation,Moscow, Russia; 3) Peoples’ Friendship University of Russia, Ministry of Science and Higher Education of the Russian Federation (RUDN University), Moscow, Russia

Periodontal diseases are among the most common in the world and are a risk factor for a large number of systemic pathological processes. These systemic conditions currently include unwanted pregnancy outcomes. This review is devoted to the analysis of the etiopathogenetic mechanisms of a relationship between periodontal diseases and unwanted pregnancy outcomes.
Publications in recent years on a given topic were analyzed.
Most researchers currently consider that the key factor that links periodontal diseases with systemic disease is the ability of a number of periodontal pathogenic bacteria to persist in the body, which reach distant organs and tissues, inducing a pronounced inflammatory response not only at the local, but also at the systemic level. In pregnant women, the incidence of periodontal diseases amounts to as much as 40% and is accompanied by a significant increase in that of preterm birth, premature rupture of membranes, low fetal weight, preeclampsia, and other adverse events. The basis for these impairments in the course of the gestational process is the development of inflammatory reactions that accompany periodontitis and become systemic with time. Inflammation in turn provokes birth activity. In addition, the appearance of periodontal pathogenic bacteria in the placenta and amniotic fluid was recorded in periodontitis diseases, which affects fetal development. Among the periodontal pathogens in these cases, Porphyromonas gingivalis prevails with its unique set of virulence factors, the ability to affect macrophages intracellularly and to induce the autoimmune processes accompanied by the production of specific cardiolipin antibodies.
Conclusion: The investigation has found a relationship between periodontal diseases and adverse pregnancy outcomes due to the unity of a number of etiopathogenetic mechanisms. The presence of these phenomena creates a prospect for prevention of unwanted pregnancy outcomes through measures aimed at treating periodontal diseases.

pregnancy

unwanted pregnancy outcomes

periodontal diseases

periodontal pathogenic bacteria

inflammation

Full text (in Russian)

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Received 05.03.2022

Accepted 24.03.2022

Anna G. Burduli, MD, PhD, Senior Researcher, Professor B.V. Leonov Department of IVF, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, burdulianna@gmail.com, https://orcid.org/0000-0002-2849-5426,
117997, Russia, Moscow, Academician Oparin str., 4.
Irina P. Balmasova, Dr. Med. Sci., Professor, Head of the Laboratory of Pathogenesis and Methods of Infectious Diseases Treatment, SRMDI, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia; Professor of Allergology and Immunology Chair, FCME of Medical Institute, RUDN University,
iri.balm@mail.ru, https://orcid.org/0000-0001-8194-2419, 117198, Russia, Moscow, Miklukho-Maklaya str., 21/3.
Viktor N. Tsarev, Dr. Med. Sci., Professor, Head of the Microbiology, Virology and Immunology Department, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, nikola777@ rambler.ru, https://orcid.org/0000-0002-3311-0367, 127473, Russia, Moscow, Delegatskaya str., 20-1.
Sergey D. Arutyunov, Dr. Med. Sci., Professor, Head of Department of Propedeutics of Dental Diseases, Dean of the Faculty of Secondary Professional Education,
A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, sd.arutyunov@mail.ru, https://orcid.org/0000-0001-6512-8724,
127473, Russia, Moscow, Delegatskaya str., 20-1.

Authors' contributions: Burduli A.G., Balmasova I.P., Tsarev V.N., Arutyunov S.D. – equal contribution to the review of publications on the topic of the article, analysis of the data obtained, writing the manuscript.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation has been conducted without additional third-party funding.
For citation: Burduli A.G., Balmasova I.P., Tsarev V.N., Arutyunov S.D.
Periodontal diseases and their association with unwanted pregnancy outcomes.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 4: 26-33 (in Russian)
https://dx.doi.org/10.18565/aig.2022.4.26-33

Periodontal diseases and their association with unwanted pregnancy outcomes

Burduli A.G., Balmasova I.P., Tsarev V.N., Arutyunov S.D.

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