Role of hypothalamic (trigger) neuropeptides in the genesis of hot flushes. Prospects for new therapeutic approaches to treating vasomotor menopausal symptoms
Objective. To carry out a systematic analysis of the data available in the current literature on the impact of the neuropeptide regulation of the hypothalamic-pituitary-ovarian axis, which in conjunction with estrogen deficiency underlie the development of vasomotor menopausal manifestations. To determine a vector of new pharmacological approaches in the therapy of menopausal disorders, by taking into account the findings of these studies.Yureneva S.V., Ebzieva Z.Kh.
Material and methods. The review includes the data of Russian and foreign articles published in the past 10 years and found in Medscape and Pubmed on this topic.
Results. The paper describes the possible mechanisms for the involvement of hypothalamic neuronal triggers in the pathogenesis of hot flushes, as well as the varying effect of pharmacological agents in reducing the severity of vasomotor symptoms. It presents new pathogenetically sound approaches to therapy for vasomotor symptoms in the treatment of menopausal syndrome.
Conclusion. There is a need for further investigations of the effect of novel medications on neuronal vasomotor triggers in the optimal therapy regimens for menopausal disorders.
Keywords
KNDy
neuropeptides
vasomotor triggers
kisspeptin
neurokinin B
dynorphin
hot flushes
menopausal syndrome
References
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Received 16.06.2017
Accepted 23.06.2017
About the Authors
Yureneva Svetlana Vladimirovna, MD, Gynecological Endocrinology Department, Research Center for Obstetrics, Gynecology and Perinatology,Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79161797400. E-mail: syureneva@gmail.com
Ebzieva Zukhra Khuseyevna, postgraduate of gynecological endocrinology department, Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79252580319. E-mail: zu87@list.ru
For citations: Yureneva S.V., Ebzieva Z.Kh. Role of hypothalamic (trigger) neuropeptides in the genesis of hot flushes. Prospects for new therapeutic approaches to treating vasomotor menopausal symptoms. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (8): 115-20. (in Russian)
http://dx.doi.org/10.18565/aig.2017.8.115-20
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