Experience with the natural non-hormonal drug Serelis in the therapy of menopausal syndrome in surgical menopausal women
Objective: To estimate changes in the frequency and severity of menopausal syndrome (MS) symptoms and psychoemotional disorders and the frequency of adverse events 12 weeks after the end of taking the natural non-hormonal drug (NHD) Serelis. Materials and methods: The investigation enrolled 90 surgical menopausal patients with MS (45 in the Serelis group and 45 in the placebo group). The investigation lasted 36 weeks. Changes were estimated in the frequency and severity of MS symptoms, in particular psychoemotional disorders, quality of life, and the frequency of adverse events. Results: After 12 weeks of treatment, there was a decrease in the severity of MS in 40/45 (88.9%) patients in the Serelis group versus 9/45(20%) in the placebo group (OR 1.12; 95% CI 0.90–4.02, p=0.048). The Serelis group showed a statistically significant decrease in the severity of neurosplanchnic and psychoemotional symptoms on the MMI scale (p=0.018 and p=0.017, respectively), the changes in the placebo group were statistically insignificant. The median total MMI score was 33.2 in the Serelis group (p=0.034) and 50.1 in the placebo group (p=0.046). There were no statistically significant differences in the total HADS scores between the groups (p=0.048). According to the WHQ questionnaire, the decrease in the mean total score amounted to as much as 33.3% in the Serelis group and 5.3% in the placebo group (p<0.001). Serelis use in the follow-up period had a long-lasting positive impact. Conclusion: The results of our study have shown that the use of the NHD Serelis allows one to achieve a significant reduction in the severity of neurosplanchnic and psychoemotional symptoms, to level off anxiety-depressive spectrum disorders, and to significantly improve quality of life.Gavrilov M.V., Puchkina G.A., Ermolenko N.S., Simacheva S.A., Sulima A.N.
Keywords
surgical menopause
menopausal syndrome
psychoemotional disorders
quality of life
cytoplasmic pollen extract
Serelis
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Received 31.08.2021
Accepted 14.09.2021
About the Authors
Mikhail V. Gavrilov, Head of the Center of Gynecology and IVF Clinic of Academician Roitberg, centr.gyn@yandex.ru, https://orcid.org/0000-0002-3957-2087,125047, Russia, Moscow, 2nd Tverskaya-Yamskaya Lane, 10.
Galina A. Puchkina, Assistant of the Department of Obstetrics, Gynecology and Perinatology No. 1, S.I. Georgievsky Medical Academy of the V.I. Vernadsky Crimean
Federal University, puchkina.g.a@mail.ru, https://orcid.org/0000-0002-8882-8317, 295051, Russia, Republic of Crimea, Simferopol, Lenin str., 5/7.
Nianila S. Ermolenko, obstetrician-gynecologist of the hospital, Academician Roitberg Clinic, ermolenko.n@medicina.ru, https://orcid.org/0000-0002-7986-5626,
125047, Russia, Moscow, 2nd Tverskaya-Yamskaya Lane, 10.
Svetlana A. Simacheva, Associate Professor of the Department of Obstetrics, Gynecology and Perinatology No. 1, S.I. Georgievsky Medical Academy of the V.I. Vernadsky Crimean Federal University, simacheva_svetla@mail.ru, https://orcid.org/0000-0002-2868-4462, 295051, Russia, Republic of Crimea, Simferopol, Lenin str., 5/7.
Anna N. Sulima, Dr. Med. Sci., Professor of the Department of Obstetrics, Gynecology and Perinatology No. 1, S.I. Georgievsky Medical Academy of the V.I. Vernadsky Crimean Federal University, https://orcid.org/0000-0002-2671-6985, 295051, Russia, Republic of Crimea, Simferopol, Lenin str., 5/7.
Authors’ contributions: Gavrilov M.V., Sulima A.N. – concept and design of the study; Gavrilov M.V., Puchkina G.A., Ermolenko N.S., Simacheva S.A. – data collection and analysis, writing of the article.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The article is published without sponsorship.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Gavrilov M.V., Puchkina G.A., Ermolenko N.S., Simacheva S.A., Sulima A.N. Experience with the natural non-hormonal drug Serelis
in the therapy of menopausal syndrome in surgical menopausal women.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 9: 134-144 (in Russian).
https://dx.doi.org/10.18565/aig.2021.9.134-144
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