Surgical menopause as a risk factor for the early development of comorbid conditions in reproductive-aged women

DOI

https://dx.doi.org/10.18565/aig.2021.6.54-59

Shabalova O.V., Yureneva S.V., Ermakova E.I., Khokhlova S.V., Gardanova Zh.R., Yakushevskaya O.V.
1) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2) N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Malignant neoplasms (MNs) of the reproductive system are the most common cancer localizations in the female population of the Russian Federation. Surgery is the most common treatment for genital MNs. Bilateral oophorectomy leads to surgical menopause (SM) and, as a result, contributes to family problems and limited professional activities, and has an extremely negative impact on quality of life in reproductive-aged women. SM is associated with body composition changes that are characterized by adipose tissue redistribution, increased visceral fat, and decreased muscle mass. Bilateral oophorectomy has been found to contribute to an impaired lipid profile, insulin resistance, and, as a result, a higher risk for cardiovascular disease (CVD) and diabetes mellitus (DM). The clinical manifestations of SM are highly diversified, and vasomotor symptoms (VMS) are some of the most painful ones, which affect up to 85% of women. VMSs reduce not only quality of life in patients, but also have an impact on their health. In patients with severe SM, the risk for CVD and DM has been established to increase by 50–77% and 20%, respectively; which correlates with the severity of SM. The most serious and intense manifestations of VMS are typical for patients with SM, especially for those with cancers, which extremely negatively affects their quality of life, by contributing to sleep problems, anxiety and depressive disorders. Another clinical manifestation of SM is an impaired attention and memory, which has a profoundly negative impact on quality of life in women and contributes to their limited professional activities. As many as 75% of cancer patients receiving chemotherapy or hormone therapy suffer from cognitive impairment.
Conclusion. The timely and adequate comprehensive treatment aimed at correcting the early and long-term consequences of sex hormone deficiency is extremely important in patients with SM and a history of reproductive system cancers.

surgical menopause

chemotherapy

metabolic disorders

diabetes mellitus

vasomotor symptoms

sleep problems

depression

cognitive impairment

Full text (in Russian)

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Received 02.06.2021

Accepted 09.06.2021

Olga V. Shabalova, graduate student, Department of Gynecological Endocrinology, Academician V.I. Kulakov National Medical Research Centre for Obstetrics,
Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(906)724-36-61. Е-mail: olga.shabalova93@gmail.com. ORCID: 0000-0001-5957-4584
4 Oparina str., Moscow, 117997, Russia.
Svetlana V. Yureneva, Dr. Med. Sci., Leading Researcher, Department of Gynecological Endocrinology, Academician V.I. Kulakov National Medical Research Centre
for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(916)179-74-00. E-mail: syureneva@gmail.com. ORCID: 0000-0003-2864-066X.
4 Oparina str., Moscow, 117997, Russia.
Elena I. Ermakova, PhD, Senior Researcher, Department of Gynecological Endocrinology, Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(903)170-98-02. E-mail: s_hohlova@oparina4.ru. ORCID: 0000-0002-4121-7228.
4 Oparina str., Moscow, 117997, Russia.
Svetlana V. Khokhlova, Dr. Med. Sci., Head of Oncology Department of Antitumor Drug Therapy, Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(903)170-98-02. E-mail: s_hohlova@oparina4.ru. ORCID: 0000-0002-4121-7228.
4 Oparina str., Moscow, 117997, Russia.
Zhanna R. Gardanova, Dr. Med. Sci., Professor, Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; Head of the Department of Psychotherapy, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia. Tel.: +7(926)538-00-83.
E-mail: zanna7777@inbox.ru. ORCID: 0000-0002-9796-0846. 4 Oparina str., Moscow, 117997, Russia.
Oksana V. Yakushevskaya, PhD, Researcher, Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. Tel.: +7(495)531-44-44. E-mail: aluckyone777@gmail.com. ORCID: 0002-7430-1207. 4 Oparina str., Moscow, 117997, Russia.

For citation: Shabalova O.V., Yureneva S.V., Ermakova E.I., Khokhlova S.V., Gardanova Zh.R., Yakushevskaya O.V. Surgical menopause as a risk factor for the early development of comorbid conditions in reproductive-aged women.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 6: 54-59 (in Russian)
https://dx.doi.org/10.18565/aig.2021.6.54-59

Surgical menopause as a risk factor for the early development of comorbid conditions in reproductive-aged women

Shabalova O.V., Yureneva S.V., Ermakova E.I., Khokhlova S.V., Gardanova Zh.R., Yakushevskaya O.V.

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