ISSN 0300-9092 (Print)
ISSN 2412-5679 (Online)

Study on recurrence prevention therapy with dienogest after laparoscopic surgery for endometriosis

Dubrovina S.O., Vovkochina M.A., Berlim Yu.D., Bogunova D.Yu., Alexandrina A.D., Bozhinskaya D.M.

1) Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don, Russia; 2) Rostov-on-Don City Hospital No. 6, Rostov-on-Don, Russia; 3) Rostov-on-Don City Emergency Hospital, Rostov-on-Don, Russia

Objective: To assess the incidence of adverse drug reactions in women taking dienogest after surgical treatment of endometriosis and to determine the influence of baseline clinical and demographic characteristics on discontinuation of recurrence prevention therapy in the postoperative period.
Materials and methods: The study included 48 female patients who underwent surgical treatment for endometriosis and received recurrence prevention therapy with dienogest for 120 days between January and March 2024.
Results: There were 38/48 (79.2%) patients who completed the full course of dienogest therapy for 120 days and 10/48 (20.8%) patients who had to discontinue therapy due to the development of undesirable adverse reactions to dienogest. The leading causes for discontinuing dienogest therapy were abnormal uterine bleeding in 6/48 (12.5%) patients and migraine in 5/48 (10.4%). Psychiatric side effects were also experienced by 5/48 (11.6%) patients, with symptoms including depressive disorders, emotional instability and cognitive impairment.
Conclusion: Regardless of age, body mass index or clinical indicators of endometriosis, the use of dienogest may be associated with a risk of adverse drug reactions and may lead to the discontinuation of recurrence prevention therapy.

Authors’ contributions: Dubrovina S.O., Vovkochina M.A., Berlim Yu.D., Bogunova D.Yu., Alexandrina A.D., Bozhinskaya D.M. – developing the concept and design of the study, collecting, processing, analysis of material and editing of sources, writing the text, editing the article.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Patient Consent for Publication: The patients signed informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Dubrovina S.O., Vovkochina M.A., Berlim Yu.D., Bogunova D.Yu., Alexandrina A.D., Bozhinskaya D.M. Study on recurrence prevention therapy with dienogest after laparoscopic surgery for endometriosis.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (5): 149-156 (in Russian)
https://dx.doi.org/10.18565/aig.2025.136

Keywords

endometriosis
side effects
depression
abnormal uterine bleeding
migraine
dienogest

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Received 21.05.2025

Accepted 29.05.2025

About the Authors

Svetlana O. Dubrovina, Professor, Dr. Med. Sci., Chief Researcher, Obstetrics and Pediatrics Research Institute, RostSMU, Ministry of Health of Russia; Professor at the Department of Obstetrics and Gynecology No. 1, RostSMU, Ministry of Health of Russia, 344012, Russia, Rostov-on-Don, Mechnikov str., 43, +7(863)250-42-00, s.dubrovina@gmail.com
Marina A. Vovkochina, obstetrician-gynecologist at the Obstetrics and Pediatrics Research Institute, Rostov SMU, Ministry of Health of Russia, 344012, Russia,
Rostov-on-Don, Mechnikov str., 43, +7(918)559-00-30, jordan-85@inbox.ru
Yulia D. Berlim, PhD, Deputy Chief Physician for the Medical Affairs, Rostov-on-Don City Hospital No. 6, 344025, Russia, Rostov-on-Don, Saryan str., 85,
+7(918)500-23-56, juliaberlim@yandex.ru
Diana Yu. Bogunova, obstetrician-gynecologist at the Obstetrics and Pediatrics Research Institute, Rostov SMU, Ministry of Health of Russia,
344022, Russia, Rostov-on-Don, Nakhichevansky lane, 29, +7(961)524-77-23, bogunovadi@yandex.ru
Anna D. Alexandrina, obstetrician-gynecologist, Rostov-on-Don City Emergency Hospital, 344068, Russia, Rostov-on-Don, Bodraya str., 88/35,
+7(904)448-58-42, anna221215@inbox.ru
Daria M. Bozhinskaya, Resident at the Department of Obstetrics and Gynecology No. 1, RostSMU, Ministry of Health of Russia; trainee obstetrician-gynecologist,
Rostov-on-Don City Hospital No. 6, 344022, Russia, Rostov-on-Don, Nakhichevansky lane, 29, +7(908)182-74-47, dasha.bozhinskaya@yandex.ru

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