Estrogen-like and antioxidant properties of resveratrol in clinical pharmacology and therapeutic use

Kareva E.N., Smetnik A.A.

1) I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia; 2) Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia
The article highlights the multi-target properties of trans-resveratrol which is a new generation of phytoestrogens with a high potential in the correction of menopausal disorders in women who cannot be prescribed menopausal hormone therapy. The article presents scientific data confirming that trans-resveratrol has a strong estrogen-like, antioxidant, cardioprotective action, as well as anti-aging and other effects. The clinical properties and mechanisms of resveratrol action are reviewed in terms of its use in gynaecology and clinical pharmacology. The article describes the effects of resveratrol on the manifestations of estrogen deficiency (vasomotor episodes, decreased bone mineral density, metabolic and psychoemotional disorders, and others). The pharmacokinetic properties of resveratrol which may limit its use in clinical practice are highlighted in the article; however, these problems can currently be solved due to the devlopment of new delivery systems. The paper shows the ways to increase the bioavailability of resveratrol which does not exceed 1% when ingested. When the medication is taken sublingually, absorption occurs quickly through the oral mucosa, thereby eliminating the effect on the intestines and metabolism in the liver during the initial passage. Due to the active component delivery systems developed with the help of modern pharmaceutical nanotechnology, it is possible to overcome the low solubility of resveratrol in water, which can significantly increase its absorbability through the oral mucosa and ensure its high bioavailability.
Conclusion: The new medication Feminaspray in the form of a sublingual spray which contains trans-resveratrol, vitamin D3 and vitamin E leads to a statistically significant decrease in the main manifestations of menopausal disorders.


hot flushes
alternative therapy
menopausal syndrome
estrogen deficiency


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Received 22.11.2021

Accepted 14.12.2021

About the Authors

Elena N. Kareva, Dr. Med. Sci., Professor of the Department of Pharmacology, I.M.Sechenov First Moscow State Medical University, Ministry of Health of Russia,
+7(499) 248-05-53,,, 119435, Moscow, Bolshaya Pirogovskaya str., 2-4.
Antonina A. Smetnik, MD, Ph.D., Head of the Department of Gynecological Endocrinology, V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, +7(495)531-44-44,,, 117997, Russia, Moscow, Ac. Oparin str., 4. RUS2200265 (v1.0)

Authors’ contributions: Kareva E.N., Smetnik A.A. – development of the concept and plan for the review of publications on the subject of the article, review of publications on the subject of the article, data analysis, writing the text of the article, approval of the article for publication.
Conflicts of interest: The authors declare that they have no competing interests.
Funding: The article was prepared with the support of Abbott Laboratories.
For citation: Kareva E.N., Smetnik A.A. Estrogen-like and antioxidant properties
of resveratrol in clinical pharmacology and therapeutic use.
Akusherstvo i Ginekologiya/ Obstetrics and Gynecology. 2021; 12: 37-48 (in Russian)

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