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Obstetrics and Gynegology2024№8
Biological and chronological aging. Ways...

Biological and chronological aging. Ways to slow down aging

DOI
https://dx.doi.org/10.18565/aig.2024.167

Khadzhieva N.Kh., Alieva A.M., Nikitin I.G.

1) Medestet Clinic, Moscow, Russia; 2) N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Cardiovascular pathology is the leading cause of mortality in the world, and it is the number one cause of death among women. A multidisciplinary approach involving cardiologists, gynecologists and therapists is necessary to overcome this problem. This article describes the differences between chronological and biological aging, with the example of vascular aging. There are three vascular aging phenotypes: premature or early vascular aging (EVA), vascular stiffness in this phenotype is characteristic of older chronological age; normal vascular aging (NOVA), arterial stiffness parameters correspond to the chronological age of a person; and supernormal vascular aging (SUPERNOVA), this phenotype is characterized by low vascular stiffness parameters for chronological age. This concept is important since it is possible to identify people with a high-risk factor for cardiovascular disease at an early stage. The menopausal transition can have an impact on the heart and vascular health in the future. Menopausal hormone therapy (MHT) is the most effective method of correcting age-related estrogen deficiency. However, taking MHT can be limited by existing contraindications or patients’ unwillingness to take hormonal medications. The decrease in the overall risk of cardiovascular diseases and coronary heart diseases by 16% and 14%, respectively, in the Western European population was associated with the consumption of soy-rich foods. Phytoestrogens alone are obviously not able to meet all the needs during therapy. Soy isoflavones in combination with other plant extracts and micronutrients in the form of the supplement Estrovel can be considered as an alternative therapy.
Conclusion: Estrovel contains a balanced combination of bioactive components and can be used as a food supplement. This is particularly beneficial for women going through the phase of menopausal transition and in the postmenopausal period, as it can help to reduce vasomotor symptoms and prevent the development of cardiovascular pathology.

Authors’ contributions: Khadzhieva N.Kh., Alieva A.M., Nikitin I.G. – developing the concept and design of the study, collecting and processing the material, writing the text, editing the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Khadzhieva N.Kh., Alieva A.M., Nikitin I.G. 
Biological and chronological aging. Ways to slow down aging.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (8): 40-46 (in Russian)
https://dx.doi.org/10.18565/aig.2024.167

Keywords

vascular aging
menopause
gut microbiome
phytoestrogens
soy isoflavones
biological aging
chronological aging
Full text (in Russian)

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Received 15.07.2024

Accepted 06.08.2024

About the Authors

Nyurzhanna Kh. Khadzhieva, PhD, obstetrician-gynecologist, Medestet Clinic, nurzhanna@yandex.ru, https://orcid.org/0000-0002-5520-281X
Amina M. Alieva, PhD, Associate Professor, Department of Hospital Therapy named after Academician G.I. Storozhakov of the Faculty of Medicine,
Pirogov Russian National Research Medical University, Ministry of Health of Russia, https://orcid.org/0000-0001-5416-8579
Igor G. Nikitin, Dr. Med. Sci., Professor, Head of the Department of Hospital Therapy named after Academician G.I. Storozhakov of the Faculty of Medicine,
Pirogov Russian National Research Medical University, Ministry of Health of Russia, https://orcid.org/0000-0003-1699-0881

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