Kisspeptin in the normal and pathological conditions

Tereschenko I.V.

Professorial Clinic, Perm, Russia

Kisspeptin is a neuropeptide that is produced in the hypothalamus and has a diverse effect on the body. The role of kisspeptin is still under study.
The objective of the presented review is to analyze recent publications on the effect of kisspeptin in the body in normal and pathological conditions.
The literature search was carried out according to the following criteria: the keyword ‘kisspeptin’ was used, publications were chosen mainly for the last 5 years; Russian literature sources were searched mainly in the publications reviewed by the State Commission for Academic Degrees and Titles, foreign sources were in the databases and services, namely PubMed, Google, and Scope.
Kisspeptin has been shown to stimulate the production of gonadotropin-releasing hormone of the hypothalamus and cause its pulsating secretion. In normal conditions, it initiates the onset of puberty, causes the development of egg cells, ovulation in women, high-quality spermatogenesis in men; moreover, it participates in conception, implantation of a fertilized egg, embryo development, placentation, provides energy homeostasis in a pregnant woman, childbirth. During pregnancy, kisspeptin is also produced by the placenta. Kisspeptin secretion is impaired in polycystic ovary syndrome, endometriosis, obesity, pregnancy complications (preeclampsia, gestational diabetes mellitus, risk of miscarriage). The role of kisspeptin in carcinogenesis is studied. Anorexigenic properties of kisspeptin have been revealed. The review includes a description of the synthesized drugs of kisspeptin and its receptor agonists.
Conclusion: In the future, it is possible to use kisspeptin in the treatment of anovulation, infertility, hypogonadism, obesity, pregnancy complications, non-alcoholic fatty liver disease and probably cancer.

Conflicts of interest: Author declares lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Tereschenko I.V. Kisspeptin in the normal and pathological conditions.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (2): 37-43 (in Russian)




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Received 13.07.2023

Accepted 25.12.2023

About the Authors

Irina V. Tereshchenko, Dr. Med. Sci., Professor, endocrinologist, MC «Professorial clinic», 614000, Russia, Perm, Druzhby str., 15А,,

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