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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2025№3
The severity of the climacteric...

The severity of the climacteric syndrome and mobility impairments in women with musculoskeletal disorders and different types of menopause

DOI
https://dx.doi.org/10.18565/aig.2025.50

Nosova L.A., Khashukoeva A.Z., Naumov A.V., Soloveva A.M., Smagina Yu.A.

1) N.I. Pirogov Russian National Research Medical University (RNRMU), Ministry of Health of Russia, Moscow, Russia; 2) Russian Gerontological Research and Clinical Center of the RNRMU, Ministry of Health of Russia, Moscow, Russia

Relevance:  With increasing life expectancy in developed countries, the incidence of age-related musculoskeletal disorders (MSDs) has increased in postmenoupausal women. There is a growing need for exploring new methods for early diagnosis of these conditions.
Objective: To explore the severity of the climacteric syndrome (CS) and mobility impairments in women aged 55–60 years with MSDs and with natural and surgical menopause. 
Materials and methods: The study included 104 female patients aged 55–60 years with CS. They were divided into 2 groups; group 1 included 54 women with natural menopause, and group 2 included 50 women with surgical menopause. Assessment of the severity of CS and locomotive syndrome (LS), the state of bone tissue measured by using fragility score,  bioimpedance analysis to evaluate  muscle tissue status, hand grip dynamometry, and the sit-and-rise test (5 times with no hands) was conducted.
Results: It was found that the group of women with surgical menopause developed severe CS manifestations. The median score of the Greene climacteric scale in this group was 12 (6;19), that was significantly higher than in the group of women with natural menopause – 8.5 (6;17) (p=0.0177). The fragility score of the lumbar spine was lower in group 1 –  26.1 (24.7; 30.8) in comparison with group 2 – 31.1 (26.1; 33.2) (p=0.023). According to the "Locomo 25" questionnaire, the median in group 2 was significantly higher – 12.0 (8; 18) versus 9.6 (3.5; 12) in group 1 (p=0.017). It was found that LS stage 1 was more common in women with natural menopause, while LS stage 2 was associated with surgical menopause.
Conclusion: The obtained results indicate a high prevalence of mobility impairments and musculoskeletal diseases in 55–60 year old women with climacteric syndrome. Therefore, further large-scale multicenter studies are needed.

Authors' contributions: Khashukoeva A.Z., Naumov A.V., Nosova L.A. – development of the concept and design of the study, statistical data analysis; Nosova L.A., Soloveva A.M., Smagina Yu.A. – material collection and processing, manuscript writing; Khashukoeva A.Z.  – manuscript editing.
Conflicts of interest: The authors confirm that they have no conflict of interest to declare.
Funding: The study was carried out without any sponsorship.
Ethical Approval: The study was approved by Independent Ethics Committee of the Pirogov Russian National Research Medical University, Ministry of Health of Russia (protocol No. 213 of December 13, 2021).
Patient Consent for Publication: The patients have signed informed consent for publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Nosova L.A., Khashukoeva A.Z., Naumov A.V., Soloveva A.M., Smagina Yu.A. 
The severity of the climacteric syndrome and mobility impairments in women 
with musculoskeletal disorders and different types of menopause.  
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (3): 92-100 (in Russian)
https://dx.doi.org/10.18565/aig.2025.50

Keywords

climacteric syndrome
menopause
locomotive syndrome
osteoporosis
osteoarthritis
sarcopenia
Full text (in Russian)

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Received 30.01.2025

Accepted 26.02.2025

About the Authors

Lilia A. Nosova, Teaching Assistant at the Department of Obstetrics and Gynecology, Institute of Surgery, Pirogov Russian National Research Medical University,
Ministry of Health of Russia, 117997, Russia, Moscow, Ostrovityanov str., 1, karelina_lilia@mail.ru, https://orcid.org/0000-0002-0925-3755
Asiyat Z. Khashukoeva, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology, Institute of Surgery, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 117997, Russia, Moscow, Ostrovityanov str., 1; obstetrician-gynecologist, Russian Gerontological Research and Clinical Center, 129226, Russia, Moscow, 1st Leonova str., 16, azk05@mail.ru, https://orcid.org/0000-0001-7591-6281
Anton V. Naumov, Dr. Med. Sci., Professor at the Department of Diseases of Aging, Faculty of Additional Professional Education, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 117997, Russia, Moscow, Ostrovityanov str., 1; Head of the Laboratory of Diseases of the Musculoskeletal System, Russian Gerontological Research and Clinical Center, 129226, Russia, Moscow, 1st Leonova str., 16, nanton@mail.ru, https://orcid.org/0000-0002-6253-621X
Anna M. Soloveva, student, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 117997, Russia, Moscow, Ostrovityanov str., 1,
annasol02@yandex.ru, https://orcid.org/0009-0006-9569-5045
Yulia A. Smagina, student, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 117997, Russia, Moscow, Ostrovityanov str., 1,
yulia-smagina709@mail.ru, https://orcid.org/0009-0009-3893-4988
Corresponding author: Asiyat Z. Khashukoeva, azk05@mail.ru

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