Retrospective analysis of risk factors for thrombotic events due to the use of combined oral contraceptives

Khamani N.M., Saidova R.A., Khamani I.V., Mashkova T.Ya., Egorova E.S., Kalashnikova I.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
Despite the improvement and widespread use of hormonal contraceptives, both one of the most reliable methods of contraception and a treatment for many gynecological diseases, various thrombotic events are still common and most dangerous side effects of these drugs.
Objective. To provide a rationale for the need to study the hemostatic system in women taking hormonal contraceptives in order to prevent venous thromboembolism.
Subjects and methods. A total of 56 reproductive-aged patients with thrombosis who received hormonal contraceptives were retrospectively analyzed.
Results. The genetic and acquired forms of thrombophilia in patients with thrombosis who took combined oral contraceptives were analyzed. 75% of them were found to present with some forms of thrombophilia. 80.5% of all patients with genetic thrombophilia had a compromised family thrombotic history.
Conclusion. The study of the hemostatic system before using combined oral contraceptives allows timely identification of women at high risk for thrombotic events.

Keywords

combined oral contraceptives
genetic thrombophilia
thrombotic events
anticoagulant therapy
hemostatic system disorders

References

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Received 08.04.2019

Accepted 19.04.2019

About the Authors

Khamani Nadina Moktarovna – Researcher, Department of Obstetrics and Gynecology, I.M. Sechenov FMSU (Sechenov University).
Address: Trubetskaya, 8, str. 2, Moscow, Russia, 119048. Теl.: +7(495)788-58-40. E-mail: nadinka@list.ru.
Saidova Ravzat Abdulatipovna – MD, Professor, Department of Obstetrics and Gynecology, I.M. Sechenov FMSU (Sechenov University).
Address: Trubetskaya str. 8, bl. 2, Moscow, Russia, 119048. Tel.: +7 (499) 788-58-40. E-mail: saidova.ra@gmail.com
Khamani Inessa Vasilievna – PhD, Associate Professor, Department of Obstetrics and Gynecology, I.M. Sechenov FMSU (Sechenov University).
Address: Trubetskaya str. 8, bl. 2, Moscow, Russia, 119048. Tel.: +7 (499) 788-58-40. E-mail: dr.hamani@list.ru.
Mashkova Tamara Yakobovna – Associate Professor, Department of Obstetrics and Gynecology, I.M. Sechenov FMSU (Sechenov University).
Address: Trubetskaya srt. 8, bl. 2, Moscow, Russia, 119048. Tel.: +7(985)721-98-98. E-mail: iza.62@mail.ru
Egorova Elena Sergeevna – Associate Professor, Department of Obstetrics and Gynecology, I.M. Sechenov FMSU (Sechenov University).
Address: Trubetskaya srt. 8, bl. 2, Moscow, Russia, 119048. Tel.: +7(910)412-06-43. E-mail: eesdoctor@mail.ru
Antonova Alexandra Sergeevna – Researcher, Department of Obstetrics and Gynecology, I.M. Sechenov FMSU (Sechenov University).
Address: Trubetskaya srt. 8, bl. 2, Moscow, Russia, 119048. Tel.: +7(916)767-26-16. E-mail: antonova.snk@inbox.ru

For citations: N.M. Khamani, R.A. Saidova, I.V. Khamani, T.Ya. Mashkova, E.S. Egorova, I.S. Kalashnikova. Retrospective analysis of risk factors for thrombotic events due to the use of combined oral contraceptives. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (6): 108-114 (in Russian).
http://dx.doi.org/10.18565/aig.2019.6.108-114

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