The effect of the combination of estetrol and drosperinone on the quality of life and sexual function of women
Karakhalis L.Yu., Tikhaya V.R., Chervonnaya I.Yu., Efremenko Yu.S., Khalafyan А.А.
Objective: To study the effect of an oral contraceptive containing estetrol 15mg and drosperinone 3mg (Esteretta) on the sexual function and the quality of life in women of reproductive age.
Materials and methods: A total of 40 women were examined whose average age was 29.5±4.2 years; they were administered a combined oral contraceptive (COC) containing estetrol 15 mg and drospirenone 3 mg. Before taking the medication and six months after it, a survey was conducted on the issues of the Female Sexual Function Index (FSFI) and on the SF-36 (Short Form Medical Outcomes Study) questionnaire about the quality of life.
Results: There was an improvement in the following parameters of quality of life in six months: PF (physical functioning) increased by 14.45 scores; role physical (RP) increased by 34.5 scores; perception of bodily pain (BP) decreased; initially low score of general health (GH) increased from 52 scores to 77.5 scores; vitality (VT) increased by 11 scores; social functioning (SF) increased by 6 scores; role emotional (RE) increased by 38 scores; low parameters of mental health which were associated with the presence of depression, anxiety, and mental ill-being increased by 18 scores. According to the results of FSFI, the number of women without difficulty in lubrication increased significantly, the number of women who had orgasm increased, and number of patients with discomfort and pain during sexual intercourse decreased.
Conclusion: The combined oral contraceptive containing estetrol 15 mg and drospirenone 3 mg significantly improved the quality of life and affected the clinical manifestations of sexual disorders.
Authors’ contributions: Karakhalis L.Yu. – development of the concept, design and methodology, analysis and interpretation of the obtained data, preparation and editing of the text, approval of the final version of the article; Tikhaya V.R., Chervonnaya I.Yu. – conducting the study (analysis and interpretation of the obtained data); Efremenko Yu.S. – conducting the study (analysis and interpretation of the obtained data), preparing the text, editing; Khalafyan A.A. – statistical analysis, editing the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was approved by the Ethical Review Board of the Kuban State Medical University, Ministry of Health of Russia, Krasnodar.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Karakhalis L.Yu., Tikhaya V.R., Chervonnaya I.Yu., Efremenko Yu.S., Khalafyan А.А. The effect of the combination of estetrol and drosperinone on the quality of life and sexual function of women.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (2): 118-122 (in Russian)
https://dx.doi.org/10.18565/aig.2024.1
Keywords
combined oral contraceptives
sexual function
quality of life
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Received 09.01.2024
Accepted 30.01.2024
About the Authors
Lyudmila Yu. Karakhalis, Dr. Med. Sci., Professor, Professor of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Continuing Education and Professional Retraining of Specialists, Kuban State Medical University, Ministry of Health of the Russian Federation, 350063, Russia, Krasnodar, Mitrofana Sedina str., 4;obstetrician-gynecologist, Regional Clinical Hospital #2», Ministry of Health of the Krasnodar Region, +7(988)244-40-44, lomela@mail.ru, https://orcid.org/0000-0003-1040-6736
Victoria R. Tikhaya, obstetrician-gynecologist, Regional Clinical Hospital #2», Ministry of Health of the Krasnodar Region, https://orcid.org/0000-0001-7174-6529
Irina Yu. Chervonnaya, PhD, obstetrics gynecologist, Yekaterininskaya Clinic, Krasnodar, https://orcid.org/0009-0000-8695-5219
Yuliya S. Efremenko, Clinical Resident, Department of Obstetrics, Gynecology and Perinatology, Faculty of Continuing Education and Professional Retraining of Specialists, Kuban State Medical University, Ministry of Health of the Russian Federation, 350063, Russia, Krasnodar, Mitrofana Sedina str., 4, yuliya2397@mail.ru,
https://orcid.org/0009-0008-4745-1411
Aleksan A. Khalafyan, Dr. Tech. Sci., Professor at the Department of Data Analysis and Artificial Intelligence FPM, Kuban State University, Ministry of Science and Higher Education of the Russian Federation, 350040, Russia, Krasnodar, Stavropolskaya str., 149, statlab@kubsu.ru, https://orcid.org/0000-0003-2324-3649
Corresponding author: Lyudmila Yu. Karakhalis, lomela@mail.ru
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