Clinical significance of determination of ADAMTS-13 metalloproteinase, its inhibitor, and von Willebrand factor in neonatal pathological conditions

Bitsadze V.O., Grigoryeva K.N., Ilalami I., Makatsariya A.D., Mingalimov M.A., Vorobyev A.V., Khizroeva D.Kh., Meng M.

1) Department of Obstetrics and Gynecology, Institute of Children’s Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia; 2) Tenon University Hospital, Faculty of Medicine, University of Sorbonne, Paris, France
The authors carried out a systematic analysis of data on the role of ADAMTS-13 metalloproteinase in the pathogenesis of different pathological conditions in the neonatal period. The review includes data from foreign and Russian articles published in the past 10 years and found in e-Library and PubMed on this topic. It presents data on diagnostic criteria, the possibilities of determining ADAMTS-13 and its inhibitors, the value of ADAMTS-13 in the development of thrombotic thrombocytopenic purpura and neonatal thrombosis. Current ideas on the possibilities of treatment and correction of the above conditions are presented.

Keywords

ADAMTS-13
thrombotic thrombocytopenic purpura
neonatal thrombosis
von Willebrand factor
hemostatic disorders
thrombophilia
anticoagulant therapy

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Received 27.09.2019

Accepted 04.10.2019

About the Authors

Viktoria O. Bitsadze, MD, PhD, Professor of the Russian Academy of Sciences, Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University. E-mail: gemostasis@mail.ru
109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.
Kristina N. Grigorieva, student of Institute of Child Health, The First I.M. Sechenov Moscow State Medical University. E-mail: grigkristik96@gmail.com
109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.
Ismail Ilalamy, MD, PhD, Professor of Hospitaux Universitares Tenon, Medical University Sorbonne, France, professor of the Department of Obstetrics and Gynecology,
The First I.M. Sechenov Moscow State Medical University; e-mail: ismail.elalamy@aphp.fr
Aleksander D. Makatsariya, MD, PhD, Academician of the Russian Academy of Sciences, Professor, Head of the Department of Obstetrics and Gynecology,
The First I.M. Sechenov Moscow State Medical University. E-mail: gemostasis@mail.ru
109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.
Marat A. Mingalimov, student of Institute of Child Health, The First I.M. Sechenov Moscow State Medical University. E-mail: ya.mingalimov2017@yandex.ru
109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.
Alexander V. Vorobev, MD, PhD, Associate Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University.
E-mail: alvorobev@gmail.com
109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.
Jamilya Kh. Khizroeva, MD, PhD, Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University. E-mail: gemostasis@mail.ru
109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.
Muyang Meng, doctoral student of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University. E-mail: gemostasis@mail.ru
109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.

For citations: Bitsadze V.O., Grigoryeva K.N., Ilalami I., Makatsariya A.D., Mingalimov M.A., Vorobyev A.V.; Khizroeva D.Kh., Meng M. Clinical significance of determination of ADAMTS-13 metalloproteinase, its inhibitor, and von Willebrand factor in neonatal pathological conditions.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 11: 74-81.(In Russian).
https://dx.doi.org/10.18565/aig.2019.11.74-81

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