A clinical case of cerebral sinus thrombosis during pregnancy after cryopreserved in vitro fertilization
Akinshina S.V., Elalami I., Vorobyev A.V., Bitsadze V.O.
Background. Cerebral venous thrombosis is a rare, but life-threatening condition that is now becoming increasingly common in obstetric and gynecological practice due to the widespread use of hormone therapy and assisted reproductive technologies.
Description. The paper presents a clinical case of cerebral sinus thrombosis during pregnancy after cryopreserved in vitro fertilization. It analyzes risk factors for cerebral venous thrombosis during pregnancy, the validity of pregnancy management tactics, and the choice of anticoagulant therapy.
Conclusion. Cerebral thrombosis can develop in the absence of classical thrombophilia in the presence of antithrombin III deficiency and imbalance in the von Willebrand factor/ADAMTS13 system due to hyperestrogenia. Adequately chosen anticoagulant therapy in patients after cerebrovascular thrombosis prevents recurrences, the development of thrombosis of other localizations, and placenta-associated pregnancy complications.
Keywords
cerebral venous thrombosis
pregnancy
thrombophilia
low-molecular-weight heparin
assisted reproductive technologies
hemostatic disorders
thrombophilia
anticoagulant therapy
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Received 14.06.2019
Accepted 21.06.2019
About the Authors
Svetlana V. Akinshina, PhD, doctoral candidate of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical Universitye-mail: gemostasis@mail.ru 109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.
Ismail Elalamy, professor of obstetrics and gynecology department of Sechenov University, Russia; Head of Department Hematology and Thrombosis Center, Medicine Sorbonne University, France. e-mail: gemostasis@mail.ru 109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.
Alexander V. Vorobev, PhD, Associate Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University.
E-mail: alvorobev@gmail.com. 109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.
Viktoria O. Bitsadze, MD, Professor of the Russian Academy of Sciences, Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University. E-mail: gemostasis@mail.ru. 109004, Moscow, ul.Zemlyanoy Val, 62, p. 1.
For citation: Akinshina S.V., Elalami I., Vorobyev A.V., Bitsadze V.O. A clinical case of cerebral sinus thrombosis during pregnancy after cryopreserved in vitro fertilization.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 9:192-7.(In Russian)
https://dx.doi.org/10.18565/aig.2019.9.192-197
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