Catastrophic antiphospholipid syndrome and thromboses

Makatsariya A.D., Serov V.N., Gris J.C., Shkoda A.S., Grigoryeva K.N., Mingalimov M.A., Bitsadze V.O., Khizroeva D.Kh., Vorobyev A.V.

1) Department of Obstetrics and Gynecology, Institute of Children’s Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia 2) Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia 3) Department of Hematology, University Hospital, Montpellier University, France 4) L.A. Vorokhobov City Clinical Hospital Sixty-Seven, Moscow Healthcare Department, Moscow, Russia
The authors have carried out a systematic analysis of data on the pathogenesis and clinical manifestations of catastrophic antiphospholipid syndrome (APS). The review includes data from foreign and Russian articles published in the past 10 years and found in e-Library and PubMed on this topic. It presents data on the pathogenesis, diagnosis, including differential one, and treatment of catastrophic APS. Risk factors for catastrophic APS should be carefully assessed for any pregnant woman who has any of these signs/symptoms: multiple organ thromboses and suspicious laboratory findings, which is present in a history of APS.

Keywords

antiphospholipid antibodies
catastrophic antiphospholipid syndrome
thrombotic microangiopathy
hemostatic disorders
thrombophilia
anticoagulant therapy

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Received 10.06.2019

Accepted 21.06.2019

About the Authors

Makatsariya Aleksander, MD, PhD, corresponding member of the Russian Academy of Sciences, Professor, Head of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University.
E-mail: gemostasis@mail.ru
109004, Moscow, st. Zemlyanoy Val, 62, p. 1.
Serov Vladimir N., MD, PhD, Professor, Academician of the Russian Academy of Sciences, Principal Researcher, Research Center for Obstetrics, Gynecology, and Perinatology; President of Russian Society of Obstetricians and Gynecologists. Тel.: +7(495) 438-72-87.  E-mail: v_serov@oparina4.ru
Jean Christophe Gris, MD, PhD, Professor of the Department of Haematology, Centre Hospitalier Rgional Universit de Montpellier, France, professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University. E-mail: jean.christophe.gris@chu-nimes.fr 109004, Moscow, st. Zemlyanoy Val, 62, p. 1.
Skoda Andrei S., MD, professor, chief physician of the L.A. Vorokhobov City Clinical Hospital No.67, Moscow Department of Health. Tel .: +7 (495) 530-30-71; e-mail: 67gkb@mail.ru 123423, Russia, Moscow, ul. Salam Adil, d. 2/44.
Grigorieva Kristina, student of paediatric faculty of The First I.M. Sechenov Moscow State Medical University. E-mail: grigkristik96@gmail.com
109004, Moscow, st. Zemlyanoy Val, 62, p. 1.
Mingalimov Marat, student of paediatric faculty of The First I.M. Sechenov Moscow State Medical University. E-mail: ya.mingalimov2017@yandex.ru
123423, Russia, Moscow, ul. Salam Adil, d. 2/44.
Bitsadze Viktoria, MD, PhD, Professor of the Russian Academy of Sciences, Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University. E-mail: gemostasis@mail.ru
123423, Russia, Moscow, ul. Salam Adil, d. 2/44.
Khizroeva Jamilya, MD, PhD, Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University.
E-mail: gemostasis@mail.ru
123423, Russia, Moscow, ul. Salam Adil, d. 2/44.
Vorobev Alexander, MD, PhD, Associate Professor of the Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University. E-mail: alvorobev@gmail.com
123423, Russia, Moscow, ul. Salam Adil, d. 2/44.

For citation: Makatsariya A.D., Serov V.N., Gris J.C., Shkoda A.S., Grigoryeva K.N., Mingalimov M.A., Bitsadze V.O., Khizroeva D.Kh., Vorobyev A.V. Catastrophic antiphospholipid syndrome and thromboses.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 9:5-14.(In Russian)
https://dx.doi.org/10.18565/aig.2019.9.5-14

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